Pubertal development underlies optimization of inhibitory control through specialization of ventrolateral prefrontal cortex

Aperiodic EEG and 7T MRSI evidence for maturation of E/I balance supporting the development of working memory through adolescence

“…DLPFC is a region that is known to be involved in visuo-spatial working memory 70 , and exhibits a protracted developmental trajectory through adolescence 71 . Both accuracy and latency, derived from the MGS task, are important but distinct components underlying overall executive function, with accuracy reflecting number of correct responses and latency reflecting the speed of information processing prior to making a response 8,72 Using the MGS task, we found significant associations between decreasing offset and decreasing response latency. While we did not find any associations between Glu GABA asymmetry and accuracy or latency, post hoc analyses showed a significant negative relationship between response latency and glutamate.…”

Adolescent neurodevelopment and psychopathology: The interplay between adversity exposure and genetic risk for accelerated brain ageing

“…Additionally, a better understanding of how adversity may impact the interaction between the HPA and hypothalamic-pituitary-gonadal (HPG) axes could provide key insights into how pubertal development may modulate the emergence of short- versus long-term (mal)adaptive responses to adverse rearing environments ( Colich and McLaughlin, 2022 ). Such a line of investigation would be certainly warranted since recent evidence points to the unique role of gonadal hormons in optimising cognitive control performance ( Ravindranath et al, 2022 ), thereby indirectly impacting the capacity to withstand stress.…”

Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control

“…For our primary analyses, 106 adolescents (50 females) ages 10–18 provided 198 usable resting-state fMRI data and reported starting puberty over 1–3 longitudinal visits (n = 50 provided data from one visit) at 12–18 month intervals (details below). One of the cohorts was also examined in a separate paper investigating puberty effects on wide-ranging connectivity and inhibitory control performance ( Ravindranath et al, 2022 ). Participants were recruited from the community and screened for the absence of neurological or psychiatric problems including loss of consciousness, self or first-degree relatives with major psychiatric illness, and MRI scanning contraindications (e.g., claustrophobia, metal in body, pregnancy).…”