Public policy and private provisions: changes in residential care from 1991 to 2001

Haynes, Philip; Banks, Laura; Balloch, Susan; Hill, Michael

doi:10.1111/j.1365-2524.2006.00638.x

Cited by 26 publications

(5 citation statements)

References 3 publications

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“…Alveolar breath sampling was performed as previously described3637. Briefly, 20 ml of exhaled gas were drawn into a gas-tight syringe (50 ml; Agilent Inc., USA).…”

Section: Methodsmentioning

confidence: 99%

Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy and Mammary Gland Fibroma

Wang

Sun

Guo

et al. 2014

Sci Rep

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The association between cancer and volatile organic metabolites in exhaled breaths has attracted increasing attention from researchers. The present study reports on a systematic study of gas profiles of metabolites in human exhaled breath by pattern recognition methods. Exhaled breath was collected from 85 patients with histologically confirmed breast disease (including 39 individuals with infiltrating ductal carcinoma, 25 individuals with cyclomastopathy and from 21 individuals with mammary gland fibroma) and 45 healthy volunteers. Principal component analysis and partial least squares discriminant analysis were used to process the final data. The volatile organic metabolites exhibited significant differences between breast cancer and normal controls, breast cancer and cyclomastopathy, and breast cancer and mammary gland fibroma; 21, 6, and 8 characteristic metabolites played decisive roles in sample classification, respectively (P < 0.05). Three volatile organic metabolites in the exhaled air, 2,5,6-trimethyloctane, 1,4-dimethoxy-2,3-butanediol, and cyclohexanone, distinguished breast cancer patients from healthy individuals, mammary gland fibroma patients, and patients with cyclomastopathy (P < 0.05). The identified three volatile organic metabolites associated with breast cancer may serve as novel diagnostic biomarkers.

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“…Alveolar breath sampling was performed as previously described3637. Briefly, 20 ml of exhaled gas were drawn into a gas-tight syringe (50 ml; Agilent Inc., USA).…”

Section: Methodsmentioning

confidence: 99%

Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy and Mammary Gland Fibroma

Wang

Sun

Guo

et al. 2014

Sci Rep

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“…Thus, Schubert and co-workers measured CO 2 [99,100] in exhaled air of mechanically ventilated patients by means of a capnograph, using a CO 2 ‑triggered alveolar sampling valve. They reported this as a reliable and reproducible method for alveolar sampling through CO 2 concentration measures.…”

Section: Sampling and Analysismentioning

confidence: 99%

Breath Analysis in Disease Diagnosis: Methodological Considerations and Applications

2014

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Breath analysis is a promising field with great potential for non-invasive diagnosis of a number of disease states. Analysis of the concentrations of volatile organic compounds (VOCs) in breath with an acceptable accuracy are assessed by means of using analytical techniques with high sensitivity, accuracy, precision, low response time, and low detection limit, which are desirable characteristics for the detection of VOCs in human breath. “Breath fingerprinting”, indicative of a specific clinical status, relies on the use of multivariate statistics methods with powerful in-built algorithms. The need for standardisation of sample collection and analysis is the main issue concerning breath analysis, blocking the introduction of breath tests into clinical practice. This review describes recent scientific developments in basic research and clinical applications, namely issues concerning sampling and biochemistry, highlighting the diagnostic potential of breath analysis for disease diagnosis. Several considerations that need to be taken into account in breath analysis are documented here, including the growing need for metabolomics to deal with breath profiles.

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“…It is also possible to simultaneously monitor mouth and nasal concentrations of breath compounds to elucidate their source ( 19 ) . Furthermore, it is possible to sample end-tidal gas only ( 20 ) by physically filtering out gas from the oral cavity (for example, by using buffered end-tidal sampling), or by data processing post hoc ( 20 , 21 ) .…”

Section: Physiological Variations In Breath Compositionmentioning

confidence: 99%

Effects of dietary nutrients on volatile breath metabolites

et al. 2013

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Breath analysis is becoming increasingly established as a means of assessing metabolic, biochemical and physiological function in health and disease. The methods available for these analyses exploit a variety of complex physicochemical principles, but are becoming more easily utilised in the clinical setting. Whilst some of the factors accounting for the biological variation in breath metabolite concentrations have been clarified, there has been relatively little work on the dietary factors that may influence them. In applying breath analysis to the clinical setting, it will be important to consider how these factors may affect the interpretation of endogenous breath composition. Diet may have complex effects on the generation of breath compounds. These effects may either be due to a direct impact on metabolism, or because they alter the gastrointestinal flora. Bacteria are a major source of compounds in breath, and their generation of H2, hydrogen cyanide, aldehydes and alkanes may be an indicator of the health of their host.

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Public policy and private provisions: changes in residential care from 1991 to 2001

Cited by 26 publications

References 3 publications

Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy and Mammary Gland Fibroma

Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy and Mammary Gland Fibroma

Breath Analysis in Disease Diagnosis: Methodological Considerations and Applications

Effects of dietary nutrients on volatile breath metabolites

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