The hospitals and nursing homes contribute 49% of the Indian healthcare delivery. Doctors and nurses, who comprise the major chunk of the healthcare sector, are vulnerable to musculoskeletal disorders (MSDs) during the course of their work routine.Arduous workplace tasks of the doctors include regular walking from ward to ward, constant bending over the bed while physically examining patients, prolonged sitting in outpatient clinics to meet the work demands. Nurses perform a wide variety of activities and are usually responsible for implementation of the care plan the doctor sets up for the patient, sometimes even in back-to-back shifts. A sample of 650 female nurses from nine Indian hospitals and 108 male doctors from four Indian hospitals was carried out. The findings revealed that nurses face considerable occupational stress, moderate levels of quality of life (QoL) and a high prevalence of MSDs. Pain and discomfort in low back, knee, neck and shoulder were found to be the most prevalent work-related musculoskeletal disorders (WMSDs) among nurses.In doctors, the results showed that the occurrence of WMSDs was most prevalent in lower back, followed by ankles/feet, knees and neck. Visual Analogue Scale revealed significant differences in the morning and evening scores. The mean total work style score exceeded the standardized limits which suggested that the work style of doctors working in Indian hospitals was at risk which may precipitate psychosocial stress.The conclusion drawn will immensely benefit the healthcare industry in developing administrative reforms and implementing welfare policy initiatives to provide a congenial working environment enhancing their QoL and better health system.