Puerarin suppresses the hepatic gluconeogenesis via activation of PI3K/Akt signaling pathway in diabetic rats and HepG2 cells

Qing, Guangyan; Qiu, Yan; Chen, Qingguang; Han, Xu; Min, Cai; Lü, Hao

doi:10.1016/j.biopha.2021.111325

Cited by 44 publications

(41 citation statements)

References 25 publications

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“… 17 , 18 These beneficial effects are closely associated with the activation of the phosphoinositide 3‐kinase (PI3K)/AKT (protein kinase B) pathway. 17 , 18 In addition, puerarin significantly reduced the cytotoxicity of reactive oxygen species (ROS) via an enhancement of catalase super oxide mutase (SOD), prevented the development of the apoptosis of pancreatic β‐cells, increased the survival capacity of β‐cells, and promoted the secretion of insulin from pancreatic islets, finally contributing to the decreases in body weight and blood glucose levels. 19 , 20 , 21 Furthermore, puerarin blocked the preadipocyte differentiation and the glucose uptake of adipocytes in insulin resistant conditions.…”

Section: Puerarin Alleviates the Clinical Relevance Of Chronic Inflammationmentioning

confidence: 99%

Effects of puerarin on chronic inflammation: Focus on the heart, brain, and arteries

2021

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Age‐associated increases in physical and mental stress, known as allostatic load, could lead to a chronic low‐grade inflammation in the heart, brain, and arteries. This low‐grade inflammation potentially contributes to adverse structural and functional remodeling, such as intimal medial thickening, endothelial dysfunction, arterial stiffening, cardiac hypertrophy and ischemia, and cognitive decline. These cellular and tissue remodeling is the fertile soil for the development of age‐associated structural and functional disorders in the cardiovascular and cerebrovascular systems in the pathogenesis of obesity, type II diabetes, hypertension, atherosclerosis, heart dysfunction, and cognitive decline. Growing evidence indicates that puerarin, a polyphenol, extracted from Puerara Labota , efficiently alleviates the initiation and progression of obesity, type II diabetes, hypertension, atherosclerosis, cardiac ischemia, cardiac arrythmia, cardiac hypertrophy, ischemic stroke, and cognition decline via suppression of oxidative stress and inflammation. This mini review focuses on recent advances in the effects of puerarin on the oxidative and inflammatory molecular, cellular, tissue events in the heart, brain, and arteries.

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Section: Puerarin Alleviates the Clinical Relevance Of Chronic Inflammationmentioning

confidence: 99%

Effects of puerarin on chronic inflammation: Focus on the heart, brain, and arteries

2021

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“…The regulation of glucose production and storage by the liver is crucial for gluconeogenesis and glycogen synthesis. The most important source of endogenous glucose production in hepatic gluconeogenesis, a hallmark in type 2 diabetes patients ( Liu et al, 2021 ).…”

Section: Hypoglycemic Mechanism Of Puerarinmentioning

confidence: 99%

“…Glucose-6-phosphatase (G6pase) and phosphoenolpyruvate carboxykinase (PEPCK) are the pivotal rate-limiting enzymes in gluconeogenesis, and Foxo1 modulates insulin sensitivity. Under the condition of insulin resistance, PI3K/Akt activity is decreased, and hepatic gluconeogenesis is promoted due to increased PEPCK and G6pase expression driven by Foxo1 ( Liu et al, 2021 ).…”

Section: Hypoglycemic Mechanism Of Puerarinmentioning

confidence: 99%

Molecular Mechanism of Puerarin Against Diabetes and its Complications

et al. 2022

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Puerarin is a predominant component of Radix Puerarin. Despite its anti-tumor and anti-virus effects and efficacy in improving cardiovascular or cerebrovascular diseases and preventing osteoporosis, it has been shown to protect against diabetes and its complications. This review summarizes the current knowledge on Puerarin in diabetes and related complications, aiming to provide an overview of antidiabetic mechanisms of Puerarin and new targets for treatment.

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“…PHL can also improve insulin resistance, enhance insulin sensitivity, and reduce BG. Meanwhile, it has been reported that PHL can inhibit the high expression of G-6-Pase (David-Silva et al, 2020;Liu et al, 2021).…”

Section: Effect Of Phl On the Expression Of G-6-pase In Postprandial Mice Livermentioning

confidence: 99%

Effects of phloridzin on blood glucose and key enzyme G‐6‐Pase of gluconeogenesis in mice

Wang

Deng

et al. 2021

J Food Biochem

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Diabetes mellitus (DM), a chronic endocrine metabolic disease, is characterized by hyperglycemia, lipid, and protein metabolism disorder. The prevalence rate of DM is high with various complications, which seriously affects the quality of life of patients, so it has been widely concerned by the society and the medical community (Ismail et al., 2017). Because of insulin resistance or impaired islet B cell function, blood glucose (BG) fluctuation often occurs during prediabetes and diabetes (Costantino et al., 2017), and long-term BG fluctuation has brought great harm.Therefore, it is of great significance to maintain the stability of BG. Liver gluconeogenesis is an important metabolic process to maintain BG homeostasis (Díaz-Lobo et al., 2015). Glucose-6-phosphatase (G-6-Pase), the key rate-limiting enzyme in the process of gluconeogenesis, is the last step to control glycogen decomposition and gluconeogenesis. G-6-Pase mainly catalyzes the hydrolysis of glucose 6-phosphate to glucose to maintain BG homeostasis. Taking liver gluconeogenesis as the target, it is of great significance to search safe and effective drugs or diet regulation methods to maintain the stability of BG, so as to control BG and reduce complications in diabetic patients (Zhang et al., 2019).

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Puerarin suppresses the hepatic gluconeogenesis via activation of PI3K/Akt signaling pathway in diabetic rats and HepG2 cells

Cited by 44 publications

References 25 publications

Effects of puerarin on chronic inflammation: Focus on the heart, brain, and arteries

Effects of puerarin on chronic inflammation: Focus on the heart, brain, and arteries

Molecular Mechanism of Puerarin Against Diabetes and its Complications

Effects of phloridzin on blood glucose and key enzyme G‐6‐Pase of gluconeogenesis in mice

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