Puerarin suppression of Aβ1–42-induced primary cortical neuron death is largely dependent on ERβ

Li, Li; Xue, Zhaohui; Chen, Lei; Chen, Xueyu; Wang, Heshuang; Wang, Xiaobo

doi:10.1016/j.brainres.2016.11.023

Cited by 22 publications

(10 citation statements)

References 42 publications

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“…Puerarin has beneficial effects against menopausal symptoms such as bone loss [25]. It has been reported that puerarin shows estrogenic activity via ERβ in various types of cells [25,29,42]. Consistent with previous reports, we also confirmed that puerarin treatment increased the translocation of ERβ and not of ERα in NHDFs.…”

Section: Plos Onesupporting

confidence: 92%

Puerarin blocks the aging phenotype in human dermal fibroblasts

et al. 2021

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Dermal fibroblast aging contributes to aging-associated functional defects in the skin since dermal fibroblasts maintain skin homeostasis by interacting with the epidermis and extracellular matrix. Here, we found that puerarin, an isoflavone present in Pueraria lobata (Kudzu), can prevent the development of the aging-phenotype in human dermal fibroblasts. Normal human dermal fibroblasts (NHDFs) were subcultivated and high-passage cells were selected as senescent cells, whereas low-passage cells were selected as a young cell control. Puerarin treatment increased cell proliferation and decreased the proportion of senescence-associated beta-galactosidase-positive cells in a high-passage culture of NHDFs. Moreover, puerarin treatment reduced the number of smooth muscle actin (SMA)-positive myofibroblasts and the expression of a reticular fibroblast marker, calponin 1 (CNN1), which were induced in high-passage NHDFs. Fulvestrant, an estrogen receptor antagonist, blocked the puerarin-mediated downregulation of SMA and CNN1. Our results suggest that puerarin may be a useful functional food that alleviates aging-related functional defects in dermal fibroblasts.

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Section: Plos Onesupporting

confidence: 92%

Puerarin blocks the aging phenotype in human dermal fibroblasts

et al. 2021

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“…It has been proposed that brain differences in the cholinergic system among males and females may underlie the differences in response to acetylcholinesterase inhibitors (AChEI) and the rate of progression of AD between sexes, with a higher benefit of AChEI treatment delaying the progression of the disease in men than women ( Giacobini and Pepeu, 2018 ). Estrogenic compounds are neuroprotective against Aβ toxicity in vitro ( Svensson and Nordberg, 1999 ; Szego et al, 2011 ; Xing et al, 2011 ; Bagheri et al, 2012 ; Wu et al, 2012 ; Napolitano et al, 2014 ; Costa et al, 2016 ; Li et al, 2017 ; You et al, 2017 ; Yang et al, 2019 ) as well as in vivo models of AD ( Bagheri et al, 2011 ; Limon et al, 2012 ; Pompili et al, 2012 ; Zhao et al, 2013 ). In one of these preclinical studies, to investigate the effect of estrogen on the cholinergic deficit in AD, different Aβ assemblies were injected in the nucleus basalis magnocellular (NBM) of sham control and OVX mice, and the viability of cholinergic cells was measured ( Szego et al, 2011 ).…”

Section: Estrogenic Plants and Compounds With Potential Effects Against Alzheimer's Diseasementioning

confidence: 99%

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

et al. 2021

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In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ovariectomy and in men and women subjected to anti-estrogen therapy. Hormone replacement therapy alleviates menopause symptoms; however, it can increase cardiovascular and cancer diseases. In the search for therapeutic alternatives, medicinal plants and specific synthetic and natural molecules with estrogenic effects have attracted widespread attention between the public and the scientific community. Various plants have been used for centuries to alleviate menstrual and menopause symptoms, such as Cranberry, Ginger, Hops, Milk Thistle, Red clover, Salvia officinalis, Soy, Black cohosh, Turnera diffusa, Ushuva, and Vitex. This review aims to highlight current evidence about estrogenic medicinal plants and their pharmacological effects on cognitive deficits induced by estrogen deficiency during menopause and aging.

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“…It was reported that, through activation of the estrogen receptor, the isoflavonoid puerarin was able to protect against Aβ induced neuronal death and promote neurite growth. 47 In addition, the ethyl acetate extract of P. mirifica tuberous roots was found to increase the level of synaptophysin, a presynaptic vesicle protein, in primary rat hippocampal neurons, which this effect is dependent on the activity of estrogen receptor. 48 In the studies of ovariectomized rodents, the ethanol extract of this plant roots along with its active components, puerarin, and miroestrol, were shown to ameliorate cognitive impairment, at least via the downregulation of genes associated with Aβ production, hyperphosphorylated Tau, brain-derived neurotrophic factor (BDNF) and cyclic AMP-responsive element-binding protein (CREB).…”

Section: Potential Thai Medicinal Plants With Anti-glutamate Toxicitymentioning

confidence: 98%

Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect

Prasansuklab

Brimson

2020

Journal of Traditional and Complementary Medicine

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Neurodegenerative diseases (NDD) are a range of debilitating conditions of the brain involving progressive loss of neurons, many of which are still currently incurable despite enormous efforts on drug discovery and development in the past decade. As NDD is closely linked to old age, the rapid worldwide growth in the aging population contributes to an increasing number of people with one of these incurable diseases and therefore it is considered a significant global health issue. There is an urgent need for novel effective treatments for NDD, and many new research strategies are centered on traditional medicine as an alternative or complementary solution. Several previous findings have suggested that glutamate toxicity drives neurodegeneration in many NDD, and the medicinal plants with anti-glutamate toxicity properties can be potentially used for their treatment. In order to obtain data relating to natural products against glutamate toxicity, six candidate plant species of Thailand were identified. Studies utilizing these herbs were searched for using the herb name (Latin and common names) along with the term “glutamate” in the following databases across all available years: PubMed, Scopus, and Google Scholar. This review emphasizes the importance of glutamate toxicity in NDD and summarizes individual plants and their active constituents with the mechanism of action against glutamate toxicity-mediated neuronal cell death that could be a promising resource for future NDD therapy. Taxonomy (classification by evise) Alzheimer’s disease, Neurodegenerative diseases, Cell culture, Molecular Biology, Traditional herbal medicine, Oxidative stress, Glutamate neurotransmitter.

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Puerarin suppression of Aβ1–42-induced primary cortical neuron death is largely dependent on ERβ

Cited by 22 publications

References 42 publications

Puerarin blocks the aging phenotype in human dermal fibroblasts

Puerarin blocks the aging phenotype in human dermal fibroblasts

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect

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