Pulmonary Ablation: A Primer

Roberton, Benjamin J.; Liu, David; Power, M.; Wan, John M. C.; Stuart, Sam; Klass, Darren; Yee, John

doi:10.1016/j.carj.2013.01.003

Cited by 7 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the clinical late follow-up, our local recurrence and overall survival rates are aligned with the recent literature (24)(25)(26)(27)(28), endorsing the current understanding that RFA is a safe and effective treatment with a survival benefit for selected patients with primary and secondary lung tumors (29,30). Unfortunately, after the first-year procedure, CT imaging follow-up was not available in the electronic medical records of many of the patients in our sample and, for this reason, the frequency of the CT findings was not evaluated.…”

Section: Discussionsupporting

confidence: 80%

Lung Radiofrequency Ablation: Post-procedure Imaging Patterns and Late Follow-up

Araújo-Filho

Menezes

Horvat

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Radiofrequency ablation (RFA) is a safe and effective minimally invasive treatment for primary or secondary malignancies of the lung. This study aims to describe imaging features on chest computed tomography (CT) after RFA of primary and secondary lung tumors, and their frequency over the time after the procedure.Methods: In this double-center retrospective study, we reviewed 69 patients with primary and secondary lung tumors who underwent percutaneous RFA. Patients were excluded if they had received concomitant radiation therapy or chemotherapy, and if there was no CT follow-up. The imaging features were assessed in four different time points: immediate post-procedure, <4 weeks, 5-24 weeks, 25-52 weeks and >52 weeks. Late follow-up (3 and 5 years after procedure) was assessed clinically in 48 patients.Results: The study population consisted of 69 patients and 144 pulmonary tumors. Six out of 69 (8.7%) patients had primary lung nodules (stage I) and 63/69 (91.3%) had metastatic pulmonary nodules. Based on per patient analysis, immediately after lung RFA, the most common CT features were consolidation (56/69, 81.1%), reversed halo (55/69, 79.7%), and hyperdensity (47/69, 68.1%). Less than 4 weeks, reversed halo was demonstrated in 19/22 (86.3%) patients, and consolidation and pleural thickening in 17/22 (77.2%). Between 5-24 weeks, 25-52 weeks and after 52 weeks, the most common imaging features were parenchymal bands. Conclusions: Our study demonstrated the expected CT features after lung RFA, a procedure which use has been progressively growing. Diagnostic and interventional radiologists should be familiar with the expected imaging features immediately after RFA and their change during follow-up in order to avoid misinterpretation and inadequate treatments.

show abstract

Section: Discussionsupporting

confidence: 80%

Lung Radiofrequency Ablation: Post-procedure Imaging Patterns and Late Follow-up

Araújo-Filho

Menezes

Horvat

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Regarding the clinical late follow-up, our local recurrence and overall survival rates are aligned with the recent literature [26][27][28][29][30], endorsing the current understanding that RFA is a safe and effective treatment with a survival benefit for selected patients with primary and secondary lung tumors [31,32]. Unfortunately, after the first-year procedure, CT imaging follow-up was not available in the electronic medical records of many of the patients in our sample and, for this reason, the frequency of the CT findings was not evaluated.…”

Section: Discussionsupporting

confidence: 78%

Lung radiofrequency ablation: post-procedure imaging patterns and late follow-up

Araújo-Filho

Menezes

Horvat

et al. 2020

European Journal of Radiology Open

View full text Add to dashboard Cite

“…Its application to the treatment of lung tumors has received great interest ( 6 ). Lung tumors may be ideal targets for RFA, since the surrounding air in the adjacent normal lung parenchyma can provide an insulating effect, subsequently concentrating the RF energy within the tumor tissue ( 7 ). However, according to a previous study, RFA is associated with increased rates of local recurrence for lung tumors with large volumes, since it is difficult to reach sufficiently high temperatures in larger tumors and achieve complete tumor destruction, as the heat source is farther removed from the deeper sections of the tumor ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone

Wan

Zhang

2015

Oncology Reports

View full text Add to dashboard Cite

Local recurrence of lung cancer following radiofrequency ablation (RFA) treatment is common. The aims of the present study were to assess how RFA treatment affects the growth of small cell lung cancer (SCLC) micrometastases in the transition zone (TZ) surrounding the ablated region and in the reference zones (RZs) of the ablated or unablated lobes and to identify the molecular mechanism(s) of lung cancer recurrence following RFA treatment. After lung micrometastases of human SCLCs had formed, RFA treatment was applied to the right upper lobe (RUL) of the lung in nude mice. Hypoxia inducible factor (HIF)-1α expression, proliferation and angiogenesis potential both in the TZ and RZ were evaluated over time. Separately, at day 1, 7 and 14 following RFA treatment, the growth of micrometastases showed an ~2-fold increase in the TZ compared to the RZ of the unablated lobe, as the right lower lobe (RLL) and the growth of micrometastases in the RZ of the RUL was also induced by RFA. In addition, accelerated tumor growth in the TZ was induced by HIF-1α, but was not associated with tissue angiogenesis potential. We concluded that local recurrences of SCLCs caused by overproliferation of micrometastases following RFA treatment were driven by HIF-1α, although angiogenesis was not the driving force in the TZ.

show abstract

Pulmonary Ablation: A Primer

Cited by 7 publications

References 39 publications

Lung Radiofrequency Ablation: Post-procedure Imaging Patterns and Late Follow-up

Lung Radiofrequency Ablation: Post-procedure Imaging Patterns and Late Follow-up

Lung radiofrequency ablation: post-procedure imaging patterns and late follow-up

Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone

Contact Info

Product

Resources

About