Pulmonary adenofibroma in a sika deer

Pulmonary adenofibroma (PAF) is a rare benign tumor. Computed tomography (CT) imaging of PAF show well-defined, homogeneous and solitary nodules. To the best of our knowledge, there is no report of PAF presenting with central liquefaction necrosis on CT images. The present study reports the case of a 70-year-old man who was hospitalized due to an inguinal hernia without respiratory symptoms. Chest CT scan revealed a tumor (~6.5x5.5x4.4 cm) in the lower lobe of the left lung, characterized by uneven density and unclear boundary with the pleura. Contrast-enhanced scan revealed that the lesion was slightly enhanced and liquefaction necrosis appeared in its center. Wedge resection was performed using video-assisted thoracic surgery. Histopathological and immunohistochemical examination confirmed the diagnosis of PAF.

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“…Currently, the pathogenesis of PAF is unclear ( 5 ). Clinical data has shown that most patients with PAF are middle-aged ( 1 ).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary adenofibroma with central liquefaction necrosis: A case report

Shen

She

2022

Exp Ther Med

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“…The neoplastic component of PAF remains controversial. Most scholars considered PAF as a biphasic tumor, composed of neoplastic epithelium and stromal spindle cells (14,(18)(19)(20). Other scholars argued that the glandular component of PAF is entrapped normal respiratory epithelium during tumor growth and only stroma is genuine neoplastic component (1,15).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Adenofibroma: Clinicopathological and Genetic Analysis of 7 Cases With Literature Review

et al. 2021

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IntroductionPulmonary adenofibroma (PAF), characterized by biphasic differentiation composed of gland-like space lined by respiratory epithelium and stromal spindle cells, is a rare benign tumor of the lung. PAF was reported infrequently and inconsistently with diagnostic criteria and withstood higher risk of misdiagnosis as solitary fibrous tumors (SFTs) due to their morphological resemblance. In this study, we report seven cases of PAF with gene sequencing results and summarize the data of previous literature.Materials and MethodsSeven cases of PAF with surgically resection samples were collected from Pathology department of West China Hospital, Sichuan University between 2009 to 2020. Immunohistochemical studies were performed in all cases and 3 cases underwent a 425-gene panel next-generation sequencing (NGS).ResultsFive female and two male patients were included in this study, with an average age of 51 years. All the patients were asymptomatic, and the lesion was identified on routine chest radiography. The tumor size measured by computed tomography (CT) ranged from 0.5 to 2.7 cm. Gland-like structures were mostly positive for glandular epithelium markers. The spindle cells in stroma expressed Desmin, SMA, ER and PR in 3 of 7 cases. No well-recognized molecular abnormalities can be identified by NGS in the 3 cases. To date, all the patients are alive, with no evidence of recurrence and metastasis.ConclusionPAF is a unique benign pulmonary tumor with low incidence. Biphasic morphology, IHC stains along with molecular detection is of great significance to make a clear diagnosis.

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Pulmonary adenofibroma in a sika deer

Cited by 2 publications

References 9 publications

Pulmonary adenofibroma with central liquefaction necrosis: A case report

Pulmonary adenofibroma with central liquefaction necrosis: A case report

Pulmonary Adenofibroma: Clinicopathological and Genetic Analysis of 7 Cases With Literature Review

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