2015
DOI: 10.2169/internalmedicine.54.4246
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Pulmonary Aluminosis Diagnosed with In-air Microparticle Induced X-ray Emission Analysis of Particles

Abstract: We herein present a case of pulmonary aluminosis diagnosed with in-air microparticle induced X-ray emission (in-air micro-PIXE) analysis. The diagnosis of pulmonary aluminosis was supported by the occupational exposure to aluminum, ground glass opacity and ill-defined centrilobular nodular opacities seen in high resolution CT, and respiratory bronchioles accompanied by pigmented dust by histological examination by in-air micro-PIXE analysis of the lung tissues. The possibility of developing this rare condition… Show more

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Cited by 13 publications
(6 citation statements)
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“…It has been reported that exposure to aluminium from welding fumes induces pulmonary aluminosis [24,25], and the inhalation of aluminium into lung parenchyma was revealed by PIXE analysis in our previous study [26]. Therefore, the presence of aluminium in this case may be due to exposure to welding fumes since asbestos does not contain aluminium.…”
Section: Discussionsupporting
confidence: 51%
“…It has been reported that exposure to aluminium from welding fumes induces pulmonary aluminosis [24,25], and the inhalation of aluminium into lung parenchyma was revealed by PIXE analysis in our previous study [26]. Therefore, the presence of aluminium in this case may be due to exposure to welding fumes since asbestos does not contain aluminium.…”
Section: Discussionsupporting
confidence: 51%
“…Pulmonary fibrosis caused by chronic inhalation of aluminum-containing dust or fumes is known as pulmonary aluminosis [6]. Radiologically, it is usually characterized by bilateral upper lung dominant reticulonodular or irregular shadows with pleural thickening, with rare exceptions of lower lung predominance, which is sometimes the case for PPFE-like lesions [4, 7].…”
Section: Discussionmentioning
confidence: 99%
“…The application of PIXE was firstly reported in 1981 by Robaye et al involving multiple procedures involving freeze-drying (Pascolo et al 2015), low temperature ashing and dissolution that completely destroys the tissues itself. Then it is improved by Annegarn et al and widely used in biomonitoring region for dust induced adverse health effects (Annegarn et al 1988;Ogasawara et al 2011;Chino et al 2015;He et al 2017). It is believed that SEM and TEM have a higher spatial resolution for this purpose, however, they are more feasible for dust characterization because the lower detection sensitivity that limit the information can be obtained from the tissues.…”
Section: Mechanisms Of Health Impacts Of Nano-dustsmentioning
confidence: 99%