Pulmonary Arteries Involvement in Takayasu's Arteritis: Two Cases and Literature Review

Toledano, K.; Guralnik, Ludmila; Lorber, Avraham; Ofer, Amos; Yigla, Mordechai; Rozin, Alexander; Markovits, Doron; Braun‐Moscovici, Yolanda; Balbir‐Gurman, Alexandra

doi:10.1016/j.semarthrit.2011.06.001

Cited by 68 publications

(104 citation statements)

References 49 publications

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“…Chest pain, shortness of breath, hemoptysis, and cough are most commonly reported [104]. Interestingly, recurrent pulmonary infarction/embolism and pulmonary hypertension (PH) are characteristic complications of Takayasu arteritis [105][106][107].…”

Section: Presentation and Diagnosismentioning

confidence: 99%

The Respiratory System in Autoimmune Vascular Diseases

Nasser¹,

Cottin²

2018

Respiration

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The respiratory system may be involved in all types of systemic vasculitis with varying significance and frequency. ANCA-associated vasculitis, including granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis, affects the respiratory tract more commonly than other vasculitis types. Granulomatosis with polyangiitis is always associated with upper or lower respiratory tract involvement. Pulmonary and ENT involvements are the hallmark feature of the disease and are present in 90 and 80% of cases, respectively, with frequent skin or gastrointestinal involvement. In about 10% of cases, the lung is the only organ affected. Eosinophilic granulomatosis with polyangiitis is always associated with hypereosinophilia and asthma which usually precedes the systemic manifestations by several years; however, onset of asthma and of the vasculitis may be concomitant. Parenchymal infiltrates may be migratory and rapidly resolve upon corticosteroid treatment. Diffuse alveolar hemorrhage and renal failure are typical features of microscopic polyangiitis. The former is the leading manifestation of anti-glomerular basement membrane disease and is usually part of a pulmonary-renal syndrome. Takayasu arteritis has a distinct clinical presentation due to pulmonary arteritis and may present with massive hemoptysis, chest pain, and rarely symptoms of pulmonary hypertension. Behçet disease is the most common cause of pulmonary artery aneurysm and can also cause in situ thrombosis of the pulmonary arteries. Corticosteroids and immunosuppressive agents are the mainstay of treatment. In conclusion, systemic vasculitis is a frequent cause of respiratory system involvement with diverse manifestations of distinct severity and outcome.

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Section: Presentation and Diagnosismentioning

confidence: 99%

The Respiratory System in Autoimmune Vascular Diseases

Nasser¹,

Cottin²

2018

Respiration

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“…It appears that isolated pulmonary artery involvement and its correlated symptoms can be the first and single signs of TA, with only 15 cases reported so far [3], none of which were associated with concomitant TB and HBV infections.…”

Section: Discussionmentioning

confidence: 99%

“…The subclavian artery is most commonly affected by TA. Involvement of the pulmonary arteries has been described in 10-50% of cases of TA, yet only about 15 cases of isolated involvement of the pulmonary arteries have been reported [3,4], none of which appeared to be related to hepatitis. We report a case of isolated pulmonary artery involvement by TA in a middle-aged Asian woman concomitantly suffering from newly diagnosed active hepatitis B virus (HBV) and latent Mycobacterium tuberculosis infection.…”

Section: Introductionmentioning

confidence: 99%

Takayasu's Arteritis with Isolated Pulmonary Artery Involvement in a Middle-Aged Asian Woman with Hepatitis B and Latent Tuberculosis Infection

Liebscher

Pfammatter

Kolios³

et al. 2017

Respiration

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We report a rare case of Takayasu's arteritis with isolated pulmonary artery stenosis in the presence of active hepatitis B and latent Mycobacterium tuberculosis infection in a middle-aged Asian woman who initially presented with severe dyspnea on exertion and recurrent syncope, occasional burning chest pains, and fatigue. Therapy of the active hepatitis B and latent M. tuberculosis infection together with a course of methotrexate led to a slight reversal of the symptoms, as angioplasty with or without stenting was not an option. The constellation described here hints at the possible link between hepatitis B and M. tuberculosis infection and the development of Takayasu's arteritis. The case also supports the little evidence available indicating that treatment of active hepatitis B infection could positively influence the course of Takayasu's arteritis.

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“…87 Presenting symptoms of pulmonary artery involvement in TA include dyspnea, cough, chest pain, and hemoptysis. 88 Pulmonary arterial hypertension is an important complication of pulmonary arteritis seen in patients with TA. Because the presenting signs and symptoms of pulmonary involvement in TA may be nonspecific or even absent, imaging plays an important role in diagnosis.…”

Section: Behçet Syndromementioning

confidence: 99%

Pulmonary Vasculitis

Lally¹,

Spiera²

2015

Rheumatic Disease Clinics of North America

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Pulmonary vasculitis encompasses inflammation in the pulmonary vasculature with involved vessels varying in caliber from large elastic arteries to capillaries. Small pulmonary capillaries are the vessels most commonly involved in vasculitis affecting the lung. The antineutrophil cytoplasmic antibody-associated vasculitides, which include granulomatosis with polyangiitis (formerly Wegener granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome), are the small vessel vasculitides in which pulmonary vasculitis is most frequently observed and are the major focus of this review. Vasculitic involvement of the large pulmonary vessels as may occur in Behçet syndrome and Takayasu arteritis is also discussed.

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Pulmonary Arteries Involvement in Takayasu's Arteritis: Two Cases and Literature Review

Cited by 68 publications

References 49 publications

The Respiratory System in Autoimmune Vascular Diseases

The Respiratory System in Autoimmune Vascular Diseases

Takayasu's Arteritis with Isolated Pulmonary Artery Involvement in a Middle-Aged Asian Woman with Hepatitis B and Latent Tuberculosis Infection

Pulmonary Vasculitis

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