This review of neoplastic diseases is an attempt to describe developments of the past two years. The reviewer has chosen to discuss only cancer in man with the specific purpose of presenting some aspects of the natural history of cancer. Extrapolation to man of the results of recent in vitro and animal studies has been deliberately avoided, with one major exception. GENERAL EFFECTS, OF TUMORS UPON THE PATIENT J The survey of literature pertaining to this review was concluded on JUly 1, 1957. Annu. Rev. Med. 1958.9:287-302. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/02/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS Annu. Rev. Med. 1958.9:287-302. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/02/15. For personal use only. Annu. Rev. Med. 1958.9:287-302. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/02/15. For personal use only.