Pulmonary artery dilatation and obstructive sleep apnea

Simonson, Joseph; Greenberg, Harley; Talwar, Arunabh

doi:10.5664/jcsm.8300

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…Pulmonary artery dilation does not necessarily correspond with elevated pulmonary artery pressures, but dilation has been associated with sleepdisordered breathing. 1,4 The association between sleep-disordered breathing and pulmonary artery dilation was further noted in our study in individuals with systemic sclerosis. 2 In the case of parenchymal lung disease, specifically chronic obstructive pulmonary disease (COPD), a prominent paper in New England Journal of Medicine suggested that pulmonary artery dilation may be predictive of COPD exacerbation.…”

supporting

confidence: 78%

“…We thank Simonson et al 1 for raising awareness about the issue of pulmonary hemodynamics and sleep-disordered breathing in patients with systemic sclerosis. 2 Regarding the link between sleep-disordered breathing and pulmonary hypertension, Sajkov et al 3 showed that pulmonary hypertension associated with obstructive sleep apnea is generally mild to moderate, reversible with positive airway pressure therapy, and often associated with marked hypoxic vasoreactivity (ie, major elevations in pulmonary artery pressure with hypoxic exposure).…”

mentioning

confidence: 99%

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Pulmonary hypertension and obstructive sleep apnea

Nokes

Raza

Malhotra

2020

Journal of Clinical Sleep Medicine

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confidence: 78%

mentioning

confidence: 99%

Pulmonary hypertension and obstructive sleep apnea

Nokes

Raza

Malhotra

2020

Journal of Clinical Sleep Medicine

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“…In patients with fibrotic lung disease, including that which may occur in scleroderma, pulmonary artery pressure may increase due to hypoxic pulmonary vasoconstriction and destruction of the lung parenchyma. Pulmonary artery expansion does not necessarily correspond to increased pulmonary artery pressure, but expansion is related to sleep-disordered breathing [ 25 , 26 ]. In patients with systemic sclerosis, we should pay close attention to the association between sleep-disordered breathing and pulmonary artery dilation [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea

Liu

Zhao

et al. 2021

BMC Pulm Med

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Objective Obstructive sleep apnoea (OSA) is one cause of pulmonary hypertension (PH) and can also emerge along with PH. The clinical diagnosis and treatment of OSA in patients with PH are still controversial. The purpose of this clinical observation study was to observe and summarize the incidence and clinical characteristics of OSA in patients with PH and to explore possible predictors of PH combined with OSA. Methods Patients with PH diagnosed by right heart catheterization who underwent overnight cardiorespiratory monitoring from December 2018 to December 2020 were enrolled. OSA was defined as an apnoea–hypopnoea index of ≥ 5/h with ≥ 50% of apnoeic events being obstructive. Baseline clinical characteristics and parameters were collected to compare PH patients with and without OSA. Logistic regression analysis was run to determine the risk factors for OSA in PH patients. Results A total of 35 (25%) of 140 patients had OSA. OSA is relatively frequent in patients with PH, especially in patients with chronic thromboembolic pulmonary hypertension and patients with lung disease– or hypoxia-associated PH. The patients who had OSA were mostly male and had a higher age and a lower daytime arterial oxygen pressure. Logistic regression analysis found that older age, male sex, and lower daytime arterial blood oxygen pressure correlated with OSA in PH patients. Conclusion OSA is common in patients with PH. Lower daytime arterial oxygen pressure is a risk factor for OSA in older male patients with PH.

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“…Obstructive sleep apnea (OSA), a common respiratory disease, causes systemic damage, including hypertension atherosclerosis and coronary artery disease. 1,2 The typical features of OSA involve sleep fragmentation and intermittent hypoxia (IH), which play a key role in OSA-related cardiovascular disease morbidity and mortality. 3,4 Endothelial dysfunction is one of the principal factors of OSA-induced cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Intermittent hypoxia: Friend or foe on endothelial repair in mouse model

Song

Chen

Wang

et al. 2021

Experimental Lung Research

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Aim of the study: Obstructive sleep apnea, which is characterized by intermittent hypoxia (IH), is a common respiratory disease. The aim of the present study was to explore the relationship between hypoxia and endothelial progenitor cell (EPC) function, and explain the role of IH in endothelial repair. Materials and methods: Peripheral blood mononuclear cells (PBMCs) were isolated from a mouse model of IH. The number of CD133 þ kinase insert domain receptor (KDR) þ , CD133 þ CD34 þ , CD34 þ KDR þ and ALDH low CD34 þ KDR þ EPCs was determined by flow cytometry. HIF-1a, stromal-derived factor-1 (SDF-1) a and VEGF were measured by ELISA. The proliferative ability of PBMCs was determined. EPC migration was assessed by Transwell assay and surface proteins by western blot analysis. EPCs were co-cultured with mouse brain endothelial cells and their angiogenic ability was analyzed. Results: The number of CD133 þ KDR þ , CD133 þ CD34 þ and CD34 þ KDR þ EPCs increased with IH ingravescence. The number of ALDH low CD34 þ KDR þ EPCs with mild IH stimulation was higher and gradually decreased in the moderate and severe IH groups. The release of HIF-1a, SDF-1a and VEGF in the serum increased with the increase in the degree of IH. In the mild IH treatment, the migration and angiogenesis of EPCs, as well as the expression of vascular endothelial growth factor receptor 2 and cysteine-X-cysteine receptor 4, were higher than those in the control group, but progressively decreased in the groups with moderate and severe IH. Conclusion: Increased levels of IH accelerated the increase in vasoactive factors in peripheral blood, thereby mobilizing a large number of EPCs. Increasing of IH diminished the mobilization, chemotactic and angiogenetic ability of EPCs.

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Pulmonary artery dilatation and obstructive sleep apnea

Cited by 3 publications

References 8 publications

Pulmonary hypertension and obstructive sleep apnea

Pulmonary hypertension and obstructive sleep apnea

The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea

Intermittent hypoxia: Friend or foe on endothelial repair in mouse model

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