Pulmonary artery distensibility and blood flow patterns: A magnetic resonance study of normal subjects and of patients with pulmonary arterial hypertension

Bogren, Hugo G.; Klipstein, R. H.; Mohiaddin, Raad H.; Firmin, David N.; Underwood, S. R.; Rees, Rowland; Longmore, D. B.

doi:10.1016/0002-8703(89)90235-4

Cited by 179 publications

(88 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the distending effect of an increase in Ppa on the vessel wall has already been evoked (1,10), the results of the present study suggest that the value of the PAH cannot be satisfactorily assessed by means of measurements of MPA CSA. In this connection, if the proposed MRI method was used as a primary test to indicate catheterization, patient 15, whose presented CSA value was high, in the absence of PAH, would have avoided the catheterization.…”

Section: Discussioncontrasting

confidence: 55%

“…In this connection, different hemodynamic parameters of pulmonary circulation such as mean, systolic, and diastolic pressures in the MPA have been studied by using focused echocardiographic Doppler examination (7,18). Also, magnetic resonance (MR) imaging has been used to assess significant variations in blood flow and cross-sectional areas (CSA) in the MPA of patients suffering from PAH compared with healthy volunteers (1,2,4,8,14,15). In particular, Mousseaux et al (14) have shown that velocity-encoded MR imaging could provide reliable measurements of cardiac output and of pulmonary vascular resistance.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method

Laffon¹,

Laurent

Bernard

et al. 2001

Journal of Applied Physiology

View full text Add to dashboard Cite

Marthan. Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method. J Appl Physiol 90: [2197][2198][2199][2200][2201][2202] 2001.-We describe a magnetic resonance (MR) imaging method that emphasizes pressure wave velocity to noninvasively assess pulmonary arterial hypertension. Both the blood flow and the corresponding vessel crosssectional area (CSA) were measured by MR phase mapping in the main pulmonary artery (MPA) in 15 patients. MPA pressures were also measured, in the same patients, by right-side heart catheterization. Two significant relationships were established: 1) between the pressure wave velocity in the MPA and the mean pressure in the MPA (Ppa) writing pressure wave velocity ϭ 9.25 Ppa Ϫ 202.51 (r ϭ 0.82) and 2) between the ratio of pressure wave velocity to the systolic blood velocity peak in the MPA (R) and the mean pressure in the MPA writing R ϭ 0.68 Ppa Ϫ 4.33 (r ϭ 0

show abstract

Section: Discussioncontrasting

confidence: 55%

mentioning

confidence: 99%

Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method

Laffon¹,

Laurent

Bernard

et al. 2001

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…It is of note that none of these subjects had any complaints or symptoms that were related to lung function or pulmonary circulation prior to the study. In accordance with earlier findings [17,18], pulmonary artery distensibility was lower in hypertensive subjects as compared to the remaining subjects with normal pulmonary pressure (8.5 5.5 versus 28.5 19.8 10 -3 mmHg -1 for Dst and 7.4 3.5 versus 26.5 19.1 10 -3 mmHg -1 for Ddyn). When pulmonary artery distensibility was related using forward stepwise multiple regression to both age and MPAP, the contribution of MPAP approached significance (table 3).…”

Section: Resultssupporting

confidence: 92%

“…PASIERSKI et al [12], however, employing the conventional ultrasound M-mode technique for measuring vessel diameter, found that the elastic modulus (the ratio of pulmonary arterial pressure to vessel wall strain) was independent of age, and was related only to pulmonary arterial pressure. It is a common finding that pulmonary artery distensibility is reduced in patients with pulmonary hypertension [17,18]. In the study of PASIERSKI et al [12] MPAP ranged 15±56 mmHg, with most of the patients being hypertensive, suggesting that the effect of age on pulmonary artery stiffness was overwhelmed by the dominating influence of pulmonary artery pressure.…”

Section: Influence Of Agementioning

confidence: 95%

“…In a subgroup of nine of the present subjects of similar age (mean 42.1 yrs; range 23±44 yrs), the corresponding value was 20.0 9.8%. BOGREN et al [17] studied the main pulmonary artery using MRI and reported a pulsatile change in cross-sectional area of 23% (range 17±30%). In earlier work on the aortic arch, in which the wall-tracking technique was used with a 3.5-MHz transducer, the recorded data were in agreement with data in the literature obtained by various techniques (angiology, mechanical and ultrasonic calliper, and magnetic resonance imaging) [23].…”

Section: Measurement Of Pulmonary Artery Dimensions With the Ultrasoumentioning

confidence: 99%

See 1 more Smart Citation

Assessment of the viscosity of the pulmonary artery wall

et al. 2000

View full text Add to dashboard Cite

Large artery wall viscosity reduces the efficiency of heart/vessel coupling. The aim of the present study was to assess pulmonary artery wall viscosity through comparison of the static (Dst) and dynamic distensibility (Ddyn) of the vessel wall.Right pulmonary artery pressure and diameter was measured in 13 patients and eight healthy volunteers. Ddyn was calculated as the relative change in end-diastolic diameter induced by the pressure pulse, and Dst as the relative change in mean diameter induced by the change in mean pressure during steady-state exercise.Dst The arterial wall responds to stress through both elastic and viscous behaviour, the former being related to the elastin and the latter to the collagen and smooth muscle content of the vessel wall [1,2]. During systole, the elastic behaviour of the arterial wall allows its diameter to increase proportionally to pressure; in the case of a purely elastic arterial wall, the total amount of energy stored would be released during diastole. In reality, however, part of the energy that corresponds to viscous deformation is dissipated within the arterial wall. Wall viscosity reduces the efficiency of heart/vessel coupling, and may place extra load on the ventricle [3].Wall viscosity is responsible for the difference that exists between the static (Dst) and dynamic distensibility (Ddyn) of a given vessel [1,2,4,5]. Under static conditions, the change in diameter in response to a given change in distending pressure is determined only by the elastic properties of the vessel wall. Under dynamic conditions, however, when changes in pressure are pulsatile and the time available for distension is limited, wall viscosity impedes distension, resulting in less change in diameter for the same change in pressure [6]. The greater the wall viscosity, the greater the difference between Dst and Ddyn. Dst has been found to be considerably higher than Ddyn in systemic arteries, the difference being accounted for by wall viscosity [1,2,4,5].Information on pulmonary artery wall viscosity is limited and controversial. In the perfused dog lungs, the slope of the static curve relating volume to pressure (i.e. lung compliance) was found to be 1.5 times steeper than that of the dynamic curve [7], indicating considerable vessel wall viscosity. In humans, no direct comparison of Dst and Ddyn of the pulmonary artery has been made, but the close similarity of pressure and diameter curves recorded from the pulmonary artery has been taken as a sign of low vessel wall viscosity [8]. The age dependence of pulmonary arterial wall distensibility is another controversial issue. Although in vitro studies have shown that the pulmonary arterial wall stiffens with age [9,10], in vivo studies have produced equivocal results; a negative correlation between pulmonary compliance and age was reported in one study [11] but no such relation was found in another [12].In view of the above uncertainties, the relationship between Dst and Ddyn of the right main pulmonary artery and its age dependence was ...

show abstract

Morphologic and functional evaluation of congenital heart disease by magnetic resonance imaging

Didier

Ratib

Beghetti

et al. 1999

J. Magn. Reson. Imaging

View full text Add to dashboard Cite

Pulmonary artery distensibility and blood flow patterns: A magnetic resonance study of normal subjects and of patients with pulmonary arterial hypertension

Cited by 179 publications

References 27 publications

Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method

Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method

Assessment of the viscosity of the pulmonary artery wall

Morphologic and functional evaluation of congenital heart disease by magnetic resonance imaging

Contact Info

Product

Resources

About