Pulmonary blood vessels and endocrine cells in subacute infantile mountain sickness

Heath, Donald; Harris, Peter; Sui, Guiling; Liu, Y.H.; Gosney, John R.; Harris, EdwardD.; Anand, Inder

doi:10.1016/s0954-6111(89)80064-2

Cited by 17 publications

(3 citation statements)

References 13 publications

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“…In Tibetans, this condition occurs in infants born to dwellers who migrated from an intermediate altitude to a significantly higher altitude [176]. Comprehensive studies with invasive measurements of pulmonary hemodynamics and postmortem pathological investigations demonstrated sustained pulmonary hypertension and substantial remodeling of small pulmonary arteries as well as hypertrophy and dilatation of the right ventricle in these patients [175,176,178]. This syndrome was coined subacute infantile mountain sickness [179].…”

Section: Pulmonary Circulation In Sea Level Residents Chronically Expmentioning

confidence: 99%

Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

Sydykov

Mamazhakypov

Maripov

et al. 2021

IJERPH

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Alveolar hypoxia is the most prominent feature of high altitude environment with well-known consequences for the cardio-pulmonary system, including development of pulmonary hypertension. Pulmonary hypertension due to an exaggerated hypoxic pulmonary vasoconstriction contributes to high altitude pulmonary edema (HAPE), a life-threatening disorder, occurring at high altitudes in non-acclimatized healthy individuals. Despite a strong physiologic rationale for using vasodilators for prevention and treatment of HAPE, no systematic studies of their efficacy have been conducted to date. Calcium-channel blockers are currently recommended for drug prophylaxis in high-risk individuals with a clear history of recurrent HAPE based on the extensive clinical experience with nifedipine in HAPE prevention in susceptible individuals. Chronic exposure to hypoxia induces pulmonary vascular remodeling and development of pulmonary hypertension, which places an increased pressure load on the right ventricle leading to right heart failure. Further, pulmonary hypertension along with excessive erythrocytosis may complicate chronic mountain sickness, another high altitude maladaptation disorder. Importantly, other causes than hypoxia may potentially underlie and/or contribute to pulmonary hypertension at high altitude, such as chronic heart and lung diseases, thrombotic or embolic diseases. Extensive clinical experience with drugs in patients with pulmonary arterial hypertension suggests their potential for treatment of high altitude pulmonary hypertension. Small studies have demonstrated their efficacy in reducing pulmonary artery pressure in high altitude residents. However, no drugs have been approved to date for the therapy of chronic high altitude pulmonary hypertension. This work provides a literature review on the role of pulmonary hypertension in the pathogenesis of acute and chronic high altitude maladaptation disorders and summarizes current knowledge regarding potential treatment options.

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Section: Pulmonary Circulation In Sea Level Residents Chronically Expmentioning

confidence: 99%

Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

Sydykov

Mamazhakypov

Maripov

et al. 2021

IJERPH

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“…69 In one case of subacute infantile mountain sickness, however, there was migration of myocytes from the media of small pulmonary arteries into the intima. 68 Heath has shown that such features are characteristic ofearly plexogenic pulmonary arteriopathy, forming the pathological basis of primary pulmonary hypertension. 70 Could this mean that the disease described in infants and children in Colorado was a late manifestation of infantile subacute mountain sickness?…”

Section: Subacute Infantile Mountain Sicknessmentioning

confidence: 99%

Hypoxia and the pulmonary circulation.

Anand¹

1994

Thorax

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“…В большинстве случаев заболевание носит фатальный характер. При патологоанатомическом исследовании выявляется значительное увеличение толщины средней оболочки мелких легочных артерий и выраженная гипертрофия правого желудочка сердца [38].…”

Section: клиническая картинаunclassified

High Altitude Pulmonary Hypertension («mirrakhimov's Disease»)

Sarybaev,

Sydykov,

Sartmyrzaeva

et al. 2016

Evrazijskij kardiologičeskij žurnal

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SUMMERY It is estimated, that more than 140 million people reside at altitudes above 2500 m in 35 countries worldwide. High altitude residents display moderate erythrocytosis and mild-to-moderate elevation in pulmonary artery pressure. Howevere, in some indivudals, severe pulmonary hypertension develop with ensuing right ventricular hypertrophy and failure and thus representing a major public health problem in mountainous regions around the world. In this review, we discuss the history of discovery, clinical findings, diagnostic, treatment and prevention of the disease. Key words: hypoxia, high altitude, pulmonary artery pressure, pulmonary hypertension, right ventricular hypertrophy.

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Pulmonary blood vessels and endocrine cells in subacute infantile mountain sickness

Cited by 17 publications

References 13 publications

Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

Pulmonary Hypertension in Acute and Chronic High Altitude Maladaptation Disorders

Hypoxia and the pulmonary circulation.

High Altitude Pulmonary Hypertension («mirrakhimov's Disease»)

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