Pulmonary Blood Volume Measured by Dual-Energy Computed Tomography Can Help Distinguish Patients With Pulmonary Hypertension

Rezaei‐Kalantari, Kiara; Samimi, Kaveh; Zomorodian, Hamid; Bakhshandeh, Hooman; Jafari, Maryam; Farahmand, Ali Mohammad; Pourseyedian, Taleb; Sharifian, Maedeh; Qanadli, Salah D.

doi:10.3389/fcvm.2022.835655

Cited by 1 publication

(1 citation statement)

References 18 publications

(35 reference statements)

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“…Moreover, it had been demonstrated that DECT is a valuable tool for diagnosing PH, regardless of the underlying mechanism or the age of the patient ( 13 , 15 ). In adults with suspected PH, it had recently been shown that pulmonary blood volume obtained through DECT was independently correlated with systolic pulmonary arterial pressure estimated by TTE ( 16 ). Due to the lack of screening tools to diagnose PH in children with SCD, we hypothesized that early signs of pulmonary vasculopathy can possibly be detected by using DECT.…”

Section: Introductionmentioning

confidence: 99%

Dual-energy computed tomography to detect early pulmonary vascular changes in children with sickle cell disease: a pilot study

Joye,

Wacker,

Nguyen

et al. 2023

Front. Pediatr.

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IntroductionPulmonary hypertension (PH) is a rare but fatal complication of sickle cell disease (SCD) that is possibly reversible if treated early. Dual-energy computed tomography (DECT) is a valuable tool for diagnosing PH. We attempted to determine if DECT can detect early signs of PH in children with SCD.MethodsThis prospective observational pilot study was conducted at the Geneva University Hospitals and was approved by the local human ethics committee (CCER 2019-01975). A written informed consent was obtained from the patients and/or their legal guardian. Eight children (consisting of five girls and three boys) with homozygous SCD were included in the study. They underwent full cardiological workup using transthoracic echocardiography (TTE) and cardiopulmonary exercise test (CPET), as well as DECT.ResultsThe median age of the children was 11 years old (range 8–12). All patients exhibited a normal biventricular systo-diastolic function using the TTE. The median tricuspid regurgitant jet velocity value was 2.24 m/s (range 1.96–2.98). Four children were found to have signs of vasculopathy detected on DECT. Of them, two had abnormal screening test results. They both had an increased VE/VCO2 slope during CPET and an increased TVR of >2.5 m/s on TTE.ConclusionDECT is capable of identifying early signs of pulmonary vascular disease in children with SCD. Further studies are needed to understand the correlation between DECT abnormalities and hemodynamic pulmonary circulation better.

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Section: Introductionmentioning

confidence: 99%