Pulmonary Blood Volume Variation Decreases after Myocardial Infarction in Pigs: A Quantitative and Noninvasive MR Imaging Measure of Heart Failure

Kanski, Mikael; Engblom, Henrik; Götberg, Matthias; Olivecrona, Göran; Erlinge, David; Heiberg, Einar; Arheden, Håkan

doi:10.1148/radiol.10090292

Cited by 27 publications

(41 citation statements)

References 36 publications

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“…Still, this may lead to underestimation of the IDC tail compared to more common models like mono-exponential and power-law model [5]. In a study of Ugander et al magnetic resonance imaging was evaluated as a method for estimating pulmonary blood volume [20]. An in-vitro validation of pulmonary blood volume measurements was carried out, showing a mean difference between the measured volumes and true volumes of 10 ± 2% for the peak-to-peak method and 4 ± 3% for the center of gravity method [20].…”

Section: Discussionmentioning

confidence: 99%

“…In a study of Ugander et al magnetic resonance imaging was evaluated as a method for estimating pulmonary blood volume [20]. An in-vitro validation of pulmonary blood volume measurements was carried out, showing a mean difference between the measured volumes and true volumes of 10 ± 2% for the peak-to-peak method and 4 ± 3% for the center of gravity method [20]. The center of gravity and peak-to-peak methods do not use model fitting for the MTT estimation, and they are more sensitive to low signal-to-noise ratios and contrast recirculation.…”

Section: Discussionmentioning

confidence: 99%

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Volume quantification by contrast-enhanced ultrasound: an in-vitro comparison with true volumes and thermodilution

Herold

Russo

Mischi

et al. 2013

Cardiovasc Ultrasound

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BackgroundContrast-enhanced ultrasound (CEUS) has recently been proposed as a minimally- invasive, alternative method for blood volume measurement. This study aims at comparing the accuracy of CEUS and the classical thermodilution techniques for volume assessment in an in-vitro set-up.MethodsThe in-vitro set-up consisted of a variable network between an inflow and outflow tube and a roller pump. The inflow and outflow tubes were insonified with an ultrasound array transducer and a thermistor was placed in each tube. Indicator dilution curves were made by injecting indicator which consisted of an ultrasound-contrast-agent diluted in ice-cold saline. Both acoustic intensity- and thermo-dilution curves were used to calculate the indicator mean transit time between the inflow and outflow tube. The volumes were derived by multiplying the estimated mean transit time by the flow rate. We compared the volumes measured by CEUS with the true volumes of the variable network and those measured by thermodilution by Bland-Altman and intraclass-correlation analysis.ResultsThe measurements by CEUS and thermodilution showed a very strong correlation (rs = 0.94) with a modest volume underestimation by CEUS of −40 ± 28 mL and an overestimation of 84 ± 62 mL by thermodilution compared with the true volumes. Both CEUS and thermodilution showed a high statistically significant correlation with the true volume (rs = 0.97 (95% CI, 0.95 - 0.98; P<0.0001) and rs = 0.96 (95% CI, 0.94 - 0.98; P<0.0001, respectively).ConclusionsCEUS volume estimation provides a strong correlation with both the true volumes in-vitro and volume estimation by thermodilution. It may therefore represent an interesting alternative to the standard, invasive thermodilution technique.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Volume quantification by contrast-enhanced ultrasound: an in-vitro comparison with true volumes and thermodilution

Herold

Russo

Mischi

et al. 2013

Cardiovasc Ultrasound

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“…In order to exclude that overt pulmonary oedema could have developed had the experiments lasted longer, we decided to extend the duration of ventilation with low V T and no PEEP to 18 h. Even so, lung weight did not increase (and it actually decreased, possibly as a consequence of exsanguination [28]) and mechanics and gas exchange did not deteriorate with time. This proves that ventilation with high PEEP and low V T over the previous 36 h had not grossly and permanently altered the permeability of the blood-gas barrier.…”

Section: Discussionmentioning

confidence: 99%

High positive end-expiratory pressure: only a dam against oedema formation?

et al. 2013

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IntroductionHealthy piglets ventilated with no positive end-expiratory pressure (PEEP) and with tidal volume (VT) close to inspiratory capacity (IC) develop fatal pulmonary oedema within 36 h. In contrast, those ventilated with high PEEP and low VT, resulting in the same volume of gas inflated (close to IC), do not. If the real threat to the blood-gas barrier is lung overinflation, then a similar damage will occur with the two settings. If PEEP only hydrostatically counteracts fluid filtration, then its removal will lead to oedema formation, thus revealing the deleterious effects of overinflation.MethodsFollowing baseline lung computed tomography (CT), five healthy piglets were ventilated with high PEEP (volume of gas around 75% of IC) and low VT (25% of IC) for 36 h. PEEP was then suddenly zeroed and low VT was maintained for 18 h. Oedema was diagnosed if final lung weight (measured on a balance following autopsy) exceeded the initial one (CT).ResultsAnimals were ventilated with PEEP 18 ± 1 cmH2O (volume of gas 875 ± 178 ml, 89 ± 7% of IC) and VT 213 ± 10 ml (22 ± 5% of IC) for the first 36 h, and with no PEEP and VT 213 ± 10 ml for the last 18 h. On average, final lung weight was not higher, and actually it was even lower, than the initial one (284 ± 62 vs. 347 ± 36 g; P = 0.01).ConclusionsHigh PEEP (and low VT) do not merely impede fluid extravasation but rather preserve the integrity of the blood-gas barrier in healthy lungs.

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“…The other major species in which rigorous determinations of pulmonary blood volume have been made are the dog, mouse, and pig. There have been a number of techniques used in describing this volume in these species (Table 4) (Milnor, 1989;Giuntini et al, 1963;Dock et al, 1961;Harris and Heath, 1986;Perasolo and Heisanken, 1971;Lewis et al, 1962Lewis et al, , 1970Backmann and Hartung, 1969;Milnor et al, 1960;Varnauskas et al, 1971;Maseri et al, 1972;Wanner et al, 1978;Zarbock et al, 2009;Ugander et al, 2010;Ou et al, 1993). Although these values are approximations, they represent a fair sampling of the values in the literature and have provided a starting point for a number of studies that have described the distribution of blood volumes between the pulmonary arteries, capillaries, and veins, and the factors that alter both the overall pulmonary blood volume and the partitioning of that volume as well.…”

Section: Quantification Of Pulmonary Blood Volumesmentioning

confidence: 99%

Pulmonary Hemodynamics

Aggarwal¹,

Groß²,

Porcelli³

et al. 2015

Comparative Biology of the Normal Lung

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Pulmonary Blood Volume Variation Decreases after Myocardial Infarction in Pigs: A Quantitative and Noninvasive MR Imaging Measure of Heart Failure

Abstract: Following infarction, the PBV variation but not PBV decreased. PBV variation was the noninvasive measure exhibiting the greatest percentage of change following infarction. MR imaging can be used to assess the variation of the PBV during the cardiac cycle as a marker of heart failure.

Cited by 27 publications

References 36 publications

Volume quantification by contrast-enhanced ultrasound: an in-vitro comparison with true volumes and thermodilution

Volume quantification by contrast-enhanced ultrasound: an in-vitro comparison with true volumes and thermodilution

High positive end-expiratory pressure: only a dam against oedema formation?

Pulmonary Hemodynamics

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