Pulmonary capillary pressure

Cope, Doris K.; Grimbert, F.; Downey, James M.; Taylor, Aubrey E.

doi:10.1097/00003246-199207000-00024

Cited by 102 publications

(43 citation statements)

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“…The measurement of the effective Pcap requires the analysis of a PAOP decay curve after balloon occlusion through different methods: (1) the visual inspection method, where the inflection point is designated as the capillary pressure; (2) a single exponential curve is fitted to the average arterial occlusion pressure decay in the segment between 0.3 s and 2 s after time 0 (occlusion); and (3) a better fit of PAOP decay curves after balloon occlusion is obtained with a biexponential function. This method of calculation led to lower Pcap values than found using a mono-exponential fitting ( Figure 3) [6,8,11] . When the PA is occluded, there is a rapid decrease in Table 2 Recommendations for right heart catheterization blood flow as the occluded downstream PA discharges its blood volume sequentially into the pulmonary capillaries across the arterial resistance and then into the pulmonary veins across the venous resistance.…”

Section: Parametersmentioning

confidence: 78%

Hemodynamic assessment of pulmonary hypertension

Grignola¹

2011

WJC

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There has been significant progress in our understanding of the pathobiology, epidemiology and prognosis of pulmonary vascular disease and, over the past few years, there has been an explosion of clinical therapeutic trials for pulmonary arterial hypertension (PAH). The increasing number of different conditions now associated with PAH and the appearance of new diagnostic techniques have led to a need for a systematic diagnostic approaches and a new disease classification, which has resulted in notable improvements in the quality and efficacy of clinical care. We appreciate traditional resting right heart catheterization techniques (which still remain the gold standard for diagnosing PAH and managing patients on therapy) and look forward to novel invasive techniques (e.g. intravascular ultrasound) that add greatly to our understanding of right ventricle and pulmonary circulation, and for the interpretation of data from clinical trials as well.

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Section: Parametersmentioning

confidence: 78%

Hemodynamic assessment of pulmonary hypertension

Grignola¹

2011

WJC

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“…The intersection between the two components of the PAP decay curve offers an estimate of PCP (Figure 1) [4]. Measurements of PCP from the analysis of the PAP decay curve after balloon occlusion have showed the evenness of PCP in the whole lung [9].…”

Section: Evenness Of Pulmonary Capillary Pressure (Pcp)mentioning

confidence: 99%

Self-Similarities of Pulmonary Arterial Tree and a New Integrated Model of Pulmonary Circulation with the Name of Fractal Phasic Perfusion (FPP) Model

Min¹

2014

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Pulmonary arterial hypertension (PAH) has become an important topic of basic and clinical research in recent years. Morphologic researches have shown that specific PAH-lesions are located in the lobular small muscular arteries and correlate with hemodynamic measurements. However, it still remains to be shown how pathological changes of the small arteries in the lobule develop to PAH. Based on both fractal properties of pulmonary arterial tree and asynchronous phasic contractions of lobular arterial muscles under the evenness of the pulmonary capillary pressure (PCP) in the lung, the author has constructed an integrated model of pulmonary circulation which has produced a mathematical relationship between the mean pulmonary arterial pressure (MPAP) and the cardiac output (CO). By use of the expression between MPAP and CO, it has been able to explain the pathogenesis of PAH in terms of statistical changes among regional and temporal perfusions in the lung. In order to detect clinically the early stage of PAH, the author has suggested that it is important to establish the pulmonary functional imaging of regional and temporal perfusions.

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“…Upper airway resistance was chosen to be 10 cm H 2 O/L/s, an average value for resistance offered to flow by a size 7 endotrachael tube for flow rates between 0.5 and 2 L/s under constant flow conditions (50). On the blood side, the model structure adopted was a modified form of that presented in (12). Parameter values for the pulmonary circulation were chosen to yield nominal values of total cardiac output, total pulmonary volume, and pulmonary arterial and venous volumes.…”

Section: Model Developmentmentioning

confidence: 99%