Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex

Rubinstein, Arye; Morecki, Rachel; Silverman, Bernard A.; Charytan, Morris; Krieger, Ben Zion; Andiman, Warren A.; Ziprkowski, Micha N.; Goldman, Harold S.

doi:10.1016/s0022-3476(86)80822-8

Cited by 187 publications

(43 citation statements)

References 18 publications

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“…2,3 Therefore, it is important for pediatricians to be familiar with the pulmonary manifestations of immunodeficiency diseases. While there are many studies on the pulmonary complications of children with acquired immunodeficiency [4][5][6][7] and some on children with humoral immunologic defects, 8,9 there are few studies on the pulmonary manifestations of children with congenital T-cell deficiency.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary diseases in children with severe combined immune deficiency and DiGeorge syndrome

et al. 1997

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Section: Introductionmentioning

confidence: 99%

Pulmonary diseases in children with severe combined immune deficiency and DiGeorge syndrome

et al. 1997

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“…Subsequent reports clearly indicated that pulmonary and cardiac disease contributed significantly to the morbidity and mortality experienced by children with human immunodeficiency virus (HIV) infection [5][6][7][8]. In response to the growing epidemic, the National Heart, Lung, and Blood Institute (NHLBI) initiated a study designed to describe the cardiovascular and pulmonary disorders that occur in children in association with vertical transmission of HIV infection from mother…”

Section: Introductionmentioning

confidence: 99%

The pediatric pulmonary and cardiovascular complications of vertically transmitted human immunodeficiency virus (P2C2 HIV) infection study: Design and methods

Kattan¹,

Peavy²,

Kalica³

et al. 1996

Journal of Clinical Epidemiology

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The P 2 C 2 HIV Study is a prospective natural history study initiated by the National Heart, Lung, and Blood Institute in order to describe the types and incidence of cardiovascular and pulmonary disorders that occur in children with vertically transmitted HIV infection (i.e., transmitted from mother to child in utero or perinatally). This article describes the study design and methods. Patients were recruited from five clinical centers in the United States. The cohort is composed of 205 infants and children enrolled after 28 days of age (Group I) and 612 fetuses and infants of HIV-infected mothers, enrolled prenatally (73%) or postnatally at age <28 days (Group II). The maternal-to-infant transmission rate in Group II was 17%. The HIV-negative infants in Group II (Group IIb) serves as a control group for the HIV-infected children (Group IIa). The cohort is followed at specified intervals for clinical examination, cardiac, pulmonary, immunologic, and infectious studies and for intercurrent illnesses. In Group IIa, the cumulative loss-to-follow-up rate at 3 years was 10.5%, and the 3-year cumulative mortality rate was 24.9%. The findings will be relevant to clinical and epidemiologic aspects of HIV infection in children.

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“…LIP is a common pulmonary complication in pediatric AIDS patients, present in Յ75% of cases (2,3). Recently, a spectrum of mucosa-associated lymphoid tissue (MALT) lesions (4), multilocular thymic cysts associated with LIP (5-8) and a spectrum of pulmonary lymphoid infiltrates have been described in pediatric HIVinfected patients (1).…”

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confidence: 99%

“…It has been postulated that bronchus-associated lymphoid tissue and LIP may represent a premalignant organ response to an antigenic stimulus (16) that may progress to MALT lymphoma. In addition, immune dysregulation is thought to be involved in the pathogenesis of LIP, which can be seen also in adults with autoimmune disease (2,8,17,18).…”

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confidence: 99%

Chemokine Gene Expression and Clonal Analysis of B Cells in Tissues Involved by Lymphoid Interstitial Pneumonitis from HIV-Infected Pediatric Patients

et al. 2001

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Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex

Cited by 187 publications

References 18 publications

Pulmonary diseases in children with severe combined immune deficiency and DiGeorge syndrome

Pulmonary diseases in children with severe combined immune deficiency and DiGeorge syndrome

The pediatric pulmonary and cardiovascular complications of vertically transmitted human immunodeficiency virus (P2C2 HIV) infection study: Design and methods

Chemokine Gene Expression and Clonal Analysis of B Cells in Tissues Involved by Lymphoid Interstitial Pneumonitis from HIV-Infected Pediatric Patients

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