Respiratory complication in CKD patients is the major cause to increase the frequency of hospitalization and acute respiratory distress in a patient with CKD is the most prevalent cause of emergency calls usually in ICU. Intensive care unit has generally focused on dialysis to maintain the renal function and on their clinical course of respiratory distress, but the most demanding diagnosis of these comorbidities was unrevealed. Diagnosis of respiratory complications in CKD patients is usually incorporated on clinical presentation and chest radiograph, which exhibits similar characteristics in most of the cases like pulmonary edema, pneumonia, and pleural effusion. The objective of this study is to evaluate the clinical parameter of respiratory complications to correlate with patient history and elucidating diagnostic challenges in a patient with CKD. In this case study, we manifested respiratory complications in a chronic dialysis patient who suddenly developed acute respiratory distress. Her clinical features and radiology results were ambiguous to make an absolute diagnosis of respiratory distress. It is demanding to get a clear picture of respiratory complications because once the diagnosis is made then it is satisfactory to establish the standard treatment protocol for this patient.