Pulmonary Effects of Carbon Nanomaterials

Wang, Liying; Davidson, Donna C.; Castranova, Vincent; Rojanasakul, Yon

doi:10.1002/9783527692866.ch6

Cited by 4 publications

(3 citation statements)

References 108 publications

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“…Besides, due to the means of administration (injection around tumors), together with their strong affinity to lymphatic systems, CNPs could mainly be deposited in LNs, while not entering into the cardiovascular system, thus, to some extent, exempting the potential toxic effect to cardiovascular, respiratory, and other systems (or organs). 41,42 And this could explain why there were no significant differences in the prevalence of postoperative complications, suggesting CNPs are a safe agent in CRC surgery. Another critical issue in LN identification is injection dose.…”

Section: Discussionmentioning

confidence: 99%

<p>Application of Carbon Nanoparticles in Tracing Lymph Nodes and Locating Tumors in Colorectal Cancer: A Concise Review</p>

Liu

Tan

et al. 2020

IJN

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Background: Accurate lymph node (LN) staging has considerably prognostic and therapeutic value in patients with colorectal cancer (CRC). The purpose of this study is to evaluate the feasibility of applying carbon nanoparticles (CNPs) to track LN metastases in CRC. Methods: Two researchers independently screened publications in PubMed, EMBASE, Cochrane and Ovid MEDLINE databases. The keywords were (carbon nanoparticles OR activated carbon nanoparticles) AND (colon cancer OR rectal cancer OR colorectal cancer). Titles and abstracts of the articles were meticulously read to rule out potential publications. Next, full texts of the ultimately obtained eligible publications were retrieved and analyzed in detail. Results: The search produced 268 publications, and 140 abstracts were identified after a bibliographic review. Finally, 20 studies relevant to our subject were obtained; however, only 14 papers met our inclusion criteria and were included for final review. All studies included have compared the control group with carbon nanoparticles group (control group, defined as nontattooed group; and carbon nanoparticles group, defined as administering carbon nanoparticles during surgery) for their efficacy in intraoperative detecting and positioning. After analysis, appreciably less amount of bleeding (3/5 trials), shorter operation time (2/4 trials), and shorter time to detect lesions and dissect LNs (2/2 trials) were revealed in CNPs group compared to control group. Thirteen studies have recorded the numbers of the harvested LNs in both groups; meanwhile, CNPs group shows superiority to control group in LN retrieval as well (11/13 trials), which also could effectively aid in locating and harvesting more LNs with diameter below 5 mm. Conclusion: The tracing technique for CNPs is a safe and useful strategy both in localizing tumor and tracing LNs in CRC surgery. But there is still a need for more randomized controlled trials to further establish its contribution to patient survival.

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Section: Discussionmentioning

confidence: 99%

<p>Application of Carbon Nanoparticles in Tracing Lymph Nodes and Locating Tumors in Colorectal Cancer: A Concise Review</p>

Liu

Tan

et al. 2020

IJN

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“…A scientific report has shown that inhalation of graphene nanoparticles can pose serious unexpected risks to lung tissues and blood circulation (Fig. 6) (Ingle et al, 2013;Schinwald et al, 2012;Wang et al, 2016). Based on empirical results, the ability of graphene and its derivatives to inhibit the activation of living cells and the circulation of blood is dose and particle size-dependent (Mukherjee, Kostarelos & Fadeel, 2018).…”

Section: Limitations Challenges and The Risk Of Using Graphene Face M...mentioning

confidence: 99%

Review on benefits, toxicity, challenges, and future of graphene-based face masks in the prevention of COVID-19 pandemic

Chaudhary

et al. 2022

PeerJ Materials Science

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The COVID-19 pandemic caused by SARS-CoV-2 has become a global public health concern. Recently, vaccines have been developed to treat this infectious disease. However, these newly developed vaccines are not widely available and not suitable for all age groups. In such circumstances, it is wise to wear personal protective equipment (PPE) such as masks, gloves, and gowns to better protect against COVID-19. Face masks have long been recommended as a means of preventing respiratory infections. However, inappropriate use of masks may undermine their effectiveness. The antimicrobial and antiviral properties of graphene have sparked interest in the development of medical devices such as face masks, gloves, and gowns with extra filtering ability to curb the effects of the coronaviruses. Their hydrophobicity, nanosize, large surface area, high electrical and thermal conductivities, and virulence are notable features that reduce the transmission of viruses from person to person via respiratory routes. Graphene-enhanced face masks are intended to encourage travelers to wear them at work and during recreational activities. Moreover, graphene can pose health hazards if inhaled during respiration. In this review, we summarize the current status of graphene and its promising applications for combating COVID-19. Additionally, this review aims to explore the quality of this biomaterial and possible suggestions for the better and safer use of graphene structured respirators.

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“…Studies in rats and mice have shown that CNTs and CNFs can pose a respiratory hazard due to pulmonary inflammation and rapidly developing, persistent fibrosis (19,52). Occupational exposure to CNTs and CNFs has been associated with biomarkers of fibrosis, inflammation, oxidative stress, and cardiovascular responses in workers (53).…”

Section: Translational Sciencementioning

confidence: 99%

Applying Translational Science Approaches to Protect Workers Exposed to Nanomaterials

Schulte

Guerin²,

Cunningham³

et al. 2022

Front. Public Health

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Like nanotechnology, translational science is a relatively new and transdisciplinary field. Translational science in occupational safety and health (OSH) focuses on the process of taking scientific knowledge for the protection of workers from the lab to the field (i.e., the worksite/workplace) and back again. Translational science has been conceptualized as having multiple phases of research along a continuum, beyond scientific discovery (T0), to efficacy (T1), to effectiveness (T2), to dissemination and implementation (D&I) (T3), to outcomes and effectiveness research in populations (T4). The translational research process applied to occupational exposure to nanomaterials might involve similar phases. This builds on basic and efficacy research (T0 and T1) in the areas of toxicology, epidemiology, industrial hygiene, medicine and engineering. In T2, research and evidence syntheses and guidance and recommendations to protect workers may be developed and assessed for effectiveness. In T3, emphasis is needed on D&I research to explore the multilevel barriers and facilitators to nanotechnology risk control information/research adoption, use, and sustainment in workplaces. D&I research for nanomaterial exposures should focus on assessing sources of information and evidence to be disseminated /implemented in complex and dynamic workplaces, how policy-makers and employers use this information in diverse contexts to protect workers, how stakeholders inform these critical processes, and what barriers impede and facilitate multilevel decision-making for the protection of nanotechnology workers. The T4 phase focuses on how effective efforts to prevent occupational exposure to nanomaterials along the research continuum contribute to large-scale impact in terms of worker safety, health and wellbeing (T4). Stakeholder input and engagement is critical to all stages of the translational research process. This paper will provide: (1) an illustration of the translational research continuum for occupational exposure to nanomaterials; and (2) a discussion of opportunities for applying D&I science to increase the effectiveness, uptake, integration, sustainability, and impact of interventions to protect the health and wellbeing of workers in the nanotechnology field.

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Pulmonary Effects of Carbon Nanomaterials

Cited by 4 publications

References 108 publications

<p>Application of Carbon Nanoparticles in Tracing Lymph Nodes and Locating Tumors in Colorectal Cancer: A Concise Review</p>

<p>Application of Carbon Nanoparticles in Tracing Lymph Nodes and Locating Tumors in Colorectal Cancer: A Concise Review</p>

Review on benefits, toxicity, challenges, and future of graphene-based face masks in the prevention of COVID-19 pandemic

Applying Translational Science Approaches to Protect Workers Exposed to Nanomaterials

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