Pulmonary fibrosis and lung cancer: risk and benefit analysis of pulmonary resection

Abstract

Patients with pulmonary fibrosis undergoing pulmonary resection for non-small cell lung cancer have increased postoperative morbidity and mortality, but an important subgroup has a good long-term outcome. Postoperative acute respiratory distress syndrome is associated with low preoperative gas transfer and a high composite physiological index. Resection of non-small cell lung cancer is appropriate in pulmonary fibrosis, provided that the level of functional impairment is carefully factored into patient selection.

Surgical Outcomes of Lung Cancer Patients with Combined Pulmonary Fibrosis and Emphysema and Those with Idiopathic Pulmonary Fibrosis without Emphysema

“…Previous studies [20][21][22][23][24][25] reported that postoperative respiratory complications were found in 26%-54.0% of patients with IPF, moderately higher than in the present study, in which the CPFE group had a significantly higher rate of cardiopulmonary morbidity than the IPF alone group; this was assumed to be due to the fact that postoperative PFT decreased unexpectedly in CPFE, involving both %VC and FEV1%, because the CPFE patients experienced AE at almost the same rate as IPF patients without emphysema and required more HOT than IPF patients without emphysema. Moreover, previous studies 7,9,10,14) noted that CPFE was highly associated with pulmonary hypertension, which might be regarded as a cause of more 19) reported that postoperative pulmonary complications occurred in 20% of CPFE patients.…”

FSP1+ Fibroblasts Promote Skin Carcinogenesis by Maintaining MCP-1-Mediated Macrophage Infiltration and Chronic Inflammation

“…For example, cancers of lung, liver, and breast are often associated with fibroblast activation, proliferation, and collagen deposition. [3][4][5] Fibroblasts may influence cancer development in different ways. Several factors secreted by fibroblasts, such as epidermal growth factor, hepatocyte growth factor, and interleukin-6 (IL-6), can stimulate cancer cell proliferation and enhance their invasive properties.…”

Perioperative Management of Severe Interstitial Pneumonia for Rectal Surgery: A Case Report

“…IP is associated with an increased risk of postoperative acute exacerbation [1]. Acute exacerbation of IP is a serious postoperative complication and the consequences are extremely poor.…”