Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19

Polese, Jéssica Fábia; Ramos, Alessandro Demoner; Moulaz, Isac Ribeiro; Santana, Larissa; Lacerda, Barbara Sthefany de Paula; Soares, Cinthia Eduarda Santos; Lança, Karen Evelin Monlevade; Thompson, Beatriz Paoli; Júnior, Germano Paulo Barbosa; Pinto, I.; Mill, José Geraldo

doi:10.1016/j.bjid.2023.102789

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…Obviously, in patients with COVID-19, respiratory function is significantly affected during the acute phase, where ICU admission may occur. Previous studies showed that the pulmonary function of patients is compromised [18,28,29] and is marked by reduced lung capacity and volume and respiratory muscle weakness [18,30]; however, there are gradual improvements in FEV1 and FVC [18,[31][32][33], especially following interventions [34]. Hence, the lung functions of surviving patients with acute lung infections are expected to improve and may be normal in the majority of patients [35].…”

Section: Discussionmentioning

confidence: 99%

Quality of Life, Family Support, Spirometry, and 6-Minute Walking Distance Differences between COVID-19 and Non-COVID-19 Intensive Care Unit Patients in One Year Following Hospital Discharge

Avgeri,

Mantzarlis,

Gerovasileiou

et al. 2024

Healthcare

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Background: Critically ill patients after Intensive Care Unit (ICU) discharge may present disability in their cognitive and physical functions. Objectives: To investigate the quality of life (QoL) of both COVID-19 and non-COVID-19 patients following ICU discharge, lung function, and physical performance of participants. Methods: This study was prospective and conducted between 2020 and 2021 in the “X” hospital. If patients were Mechanically-Ventilated (MV) > 48 h, they were included. Results: Fifty COVID-19 and seventy-two non-COVID-19 participants were included in this study. The mean (SD) of the total SF-36 scores at COVID-19 patients at hospital discharge and 3 and 12 months were 46.5 (14.5), 68.6 (17.8), and 82.3 (8.9) (p < 0.05), while non-COVID-19 participants were 48.5 (12.1), 72.2 (9.9), and 82.7 (5.4) (p < 0.05). The forced expiratory volume in one second (FEV1) and 6-minute walking distance (6MWD) were assessed at 3 and 12 months and significantly improved over 12 months. Conclusion: The QoL of COVID-19 patients improved significantly over time as FEV1 and 6MWD.

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Section: Discussionmentioning

confidence: 99%

Quality of Life, Family Support, Spirometry, and 6-Minute Walking Distance Differences between COVID-19 and Non-COVID-19 Intensive Care Unit Patients in One Year Following Hospital Discharge

Avgeri,

Mantzarlis,

Gerovasileiou

et al. 2024

Healthcare

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“…Numa coorte de 41 pacientes que necessitaram internação hospitalar por, em média, 9 dias, 80% apresentavam função pulmonar diminuída 30 dias após alta, a qual persistiu por até 6 meses em cerca de 10% dos pacientes, alguns deles com sinais claros de síndrome pulmonar restritiva, fator limitante para o esforço físico. 3 , 4 …”

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confidence: 99%

“…In a cohort of 41 patients who required hospitalization for, on average, 9 days, 80% had reduced lung function 30 days after discharge, which persisted for up to 6 months in around 10% of patients, some of them with clear signs of restrictive pulmonary syndrome, limiting factor for physical effort. 3,4 The persistence of symptoms led the World Health Organization to define the post-Covid syndrome or Long Covid as a new clinical entity appearing in patients recovered from SARS-CoV-2 infection. The syndrome is characterized by the persistence, for more than 3 months, of symptoms that cannot be explained by a condition prior to the viral infection.…”

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confidence: 99%

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Síndrome Pós-COVID ou COVID Longa: Um Novo Desafio para o Sistema de Saúde

Mill,

Polese

2023

Arquivos Brasileiros De Cardiologia

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Effect of home-based pulmonary rehabilitation on exercise capacity in post COVID-19 patients: a randomized controlled trail

Elyazed,

Alsharawy,

Salem

et al. 2024

J NeuroEngineering Rehabil

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Background Coronavirus 2019 (COVID-19) is an epidemic condition that compromises various consequences. The goal of this study was to investigate the effect of home-based pulmonary rehabilitation on exercise capacity in patients with post COVID-19 syndrome. Methods The study was designed as a randomized control trial. A total of sixty-eight patients with post COVID-19 syndrome complaining of fatigue, dyspnea, and exercise intolerance participated in this study. Their ages ranged from 40 to 70 years old. The patients were randomly classified into two equal groups. The control group received usual medical care only, whereas the rehabilitation group received a selected home-based pulmonary rehabilitation exercise program plus the same usual medical care. The Physical Fitness Index (PFI), Chalder fatigue index, SF-36 questionnaire, dyspnea scale, and six-minute walk test (6 MWT) were measured before and after 12 weeks of intervention. Results The rehabilitation group showed a significant lower mean of Chalder fatigue (11.1 ± 0.94) and a higher mean of 6MWT (439.7 ± 25.3) and PFI (52.3 ± 10.2), in addition to a higher mean of the SF-36 Questionnaire (66.4 ± 3.7) and a significant improvement of dyspnea in the mMRC score (26.7%), grade 2, (63.3%), grade 1 (10%), and grade 0 with a p-value < 0.001 when compared to the control group. Conclusion Home-based pulmonary rehabilitation (HBPR) for patients with post COVID-19 syndrome is effective and has a potential direct influence on exercise capacity, fatigue, dyspnea, and quality of life. HBPR could be considered an adjunctive, applicable, and low-cost therapy for patients with post COVID-19 syndrome. Trial registration: The study was registered in Pan African Clinical Trial Registry as a clinical trial ID (PACTR202111640499636), November 2021.

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Pulmonary function and exercise capacity six months after hospital discharge of patients with severe COVID-19

Cited by 4 publications

References 29 publications

Quality of Life, Family Support, Spirometry, and 6-Minute Walking Distance Differences between COVID-19 and Non-COVID-19 Intensive Care Unit Patients in One Year Following Hospital Discharge

Quality of Life, Family Support, Spirometry, and 6-Minute Walking Distance Differences between COVID-19 and Non-COVID-19 Intensive Care Unit Patients in One Year Following Hospital Discharge

Síndrome Pós-COVID ou COVID Longa: Um Novo Desafio para o Sistema de Saúde

Effect of home-based pulmonary rehabilitation on exercise capacity in post COVID-19 patients: a randomized controlled trail

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