Pulmonary function tests in type 1 diabetes adolescents with diabetic cardiovascular autonomic neuropathy

Ďurdík, Peter; Vojtková, Jarmila; Michnová, Zuzana; Turčan, Tomáš; Šujanská, Anna; Kuchta, M.; Ciljakova, Miriam

doi:10.1016/j.jdiacomp.2015.10.011

Cited by 9 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of autonomic neuropathy in lung injury is less clear but not completely excluded [34]. The vagus nerve, involved in parasympathetic innervation of the heart, also has a role in the innervation of the respiratory muscles.…”

Section: Pathogenesis Of Diabetes-induced Lung Damagementioning

confidence: 99%

See 1 more Smart Citation

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

et al. 2021

View full text Add to dashboard Cite

Historically, the lung was not listed and recognized as a major target organ of diabetic injury. The first evidence of diabetic lung involvement was published fifty years ago, with a study conducted in a population of young adults affected by type 1 diabetes (T1D). In recent years, there has been mounting evidence showing that the lung is a target organ of diabetic injury since the beginning of the disease—at the pediatric age. The deeply branched vascularization of the lungs and the abundance of connective tissue, indeed, make them vulnerable to the effects of hyperglycemia, in a way similar to other organs affected by microvascular complications. In this review, we focus on pulmonary function impairment in children and adolescents affected by T1D. We also cover controversial aspects regarding available studies and future perspectives in this field.

show abstract

Section: Pathogenesis Of Diabetes-induced Lung Damagementioning

confidence: 99%

“…Some authors showed how cardiovascular autonomic neuropathy can be associated with reduced pulmonary functions in adolescents with T1D. However, more studies are needed to support these data [34].…”

Section: Pathogenesis Of Diabetes-induced Lung Damagementioning

confidence: 99%

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This finding reinforces the use of reduced DLCO as a marker of poor performance during exercise in individuals with SCA. It is also worth noting the relationships observed between the GA-T time and the PMF measures in our study, which indicate that the microvascular obstruction and the oxidative stress characteristic of SCA can negatively impact the peripheral muscles and reduce the performance of individuals during exercise (31)(32)(33).…”

Section: Discussionmentioning

confidence: 53%

“…These finding are in line with those observed by Pitocco et al (32) in individuals with type 1 diabetes, where they found a close relationship between ANS dysfunction and DLCO measures. It is hypothesized that ANS imbalance may modify the functioning of the peripheral and coronary microvasculature and play a role in abnormal regulation of pulmonary microcirculation (33). Thus, we hypothesized that ANS dysfunction is involved in the early reduction in DLCO in people with SCA, possibly due to abnormal blood flow regulation at the pulmonary microvascular level.…”

Section: Discussionmentioning

confidence: 98%

“…A relationship between ANS behavior and pulmonary function has been discussed under both normal and pathological conditions (32)(33)(34)(35). It has been hypothesized that HRV may be influenced by pulmonary function, regardless of cardiac autonomic control, with an increasingdecreasing HR resulting from a biphasic vagal response during the respiratory cycle that leads to instantaneous fluctuations in HRV-the so-called "respiratory sinus arrhythmia" (29,35).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Heart Rate Variability in Adults with Sickle Cell Anemia During a Multitasking Field Test

et al. 2021

View full text Add to dashboard Cite

Background: The integrity of the autonomic nervous system (ANS) is essential for keeping physiological processes stable, even under stress. Since there is growing interest in heart rate variability (HRV) analysis for the noninvasive assessment of the ANS in sickle cell anemia (SCA) patients, we studied the behavior of the ANS in the presence of a stressor that simulates daily-life multitasking, the Glittre ADL test (GA-T). Objectives: To evaluate the involvement of the ANS using HRV in adults with SCA during the GA-T and to quantify the strength of the correlation of HRV with lung and muscle functions. Methods: In this cross-sectional study, 16 adults with SCA and 12 healthy controls without sickle cell disease underwent HRV assessment during the GA-T, pulmonary function tests (spirometry, diffusing capacity for carbon monoxide (DLCO), and respiratory muscle testing). Peripheral muscle function [handgrip strength (HGS) and quadriceps strength (QS)] were also measured. Results: Compared to the healthy controls, adults with SCA showed lower HRV, with worse parasympathetic modulation due to reductions in the following indices: the root-mean-square difference of successive normal iRRs (iRR) (RMSSD); the percentage of pairs of consecutive iRRs whose difference is > 50 m (pNN50); the high-frequency component of heart rate variability (HF); and the standard deviation of instantaneous beat-to-beat variability (SD1) (P < 0.001 for all). Compared to healthy controls, individuals with SCA showed greater sympathovagal imbalance (higher ratio between low-frequency and HF components) and lower complexity of the ANS (lower approximate entropy). The GA-T time was correlated with parasympathetic activity indices: RMSSD (rs = -0.650, P < 0.01); pNN50 (rs = -0.932, P < 0.0001), HF (rs = -0.579, P < 0.01), and SD1 (rs = -0.814, P < 0.0001). Correlations between parasympathetic activity indices and DLCO, HGS, and QS measures were also significant. Conclusions: Adults with SCA have low HRV, with low parasympathetic activity, sympathovagal imbalance, and abnormal ANS complexity. In addition, lower HRV is associated with longer GA-T time, greater impairment of pulmonary diffusion, and greater muscle strength dysfunction.

show abstract

Diabetes Mellitus and Exercise Physiology in the Presence of Diabetic Comorbidities

Schauer¹,

Huebschmann²,

Regensteiner³

2017

Contemporary Diabetes

View full text Add to dashboard Cite

Pulmonary function tests in type 1 diabetes adolescents with diabetic cardiovascular autonomic neuropathy

Cited by 9 publications

References 26 publications

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

The Diabetic Lung: Insights into Pulmonary Changes in Children and Adolescents with Type 1 Diabetes

Heart Rate Variability in Adults with Sickle Cell Anemia During a Multitasking Field Test

Diabetes Mellitus and Exercise Physiology in the Presence of Diabetic Comorbidities

Contact Info

Product

Resources

About