Pulmonary Functional Imaging: Qualitative Comparison of Fourier Decomposition MR Imaging with SPECT/CT in Porcine Lung

Bauman, Grzegorz; Lützen, Ulf; Ullrich, Mathias; Gaaß, Thomas; Dinkel, Julien; Elke, Gunnar; Meybohm, Patrick; Frerichs, Inéz; Hoffmann, B.; Borggrefe, Jan; Knuth, Hans-Christian; Schupp, Jasper; Prüm, Hermann; Eichinger, Monika; Puderbach, Michael; Biederer, Jürgen; Hintze, C.

doi:10.1148/radiol.11102313

Cited by 104 publications

(77 citation statements)

References 22 publications

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“…4 The present case initially confirms this correlation in human application. FD-MRI has the potential to play a future role in functional lung MRI for perfusion and ventilation assessment especially in certain subgroups with contraindications for other types of imaging or when particular radiation protection is mandatory.…”

supporting

confidence: 83%

Acute Pulmonary Artery Embolism Detected by Noncontrast Functional Lung Magnetic Resonance Imaging

Kestler

Weng

Kunz

et al. 2016

Circ: Cardiovascular Imaging

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A 30-year-old woman presented to the emergency department with acute shortness of breath, dizziness, and leftsided thoracic pain. The patient had been diagnosed with adenocarcinoma of the lung and metastases in central nervous system, liver, and bones 2 years earlier. After initial radiation and chemotherapeutic treatment, the patient showed a mixed response and was subsequently treated with the tyrosinekinase inhibitor crizotinib, as well as further radiation of the progressive and symptomatic cerebral metastases.On admission, the patient was afebrile, displayed unimpaired oxygen saturation in room air, and presented with mild pitting edema of the calves. The ECG was without pathological findings and d-dimers were slightly elevated. Because of her clinical presentation and the increased pretest probability (clinical presentation and cancer diagnosis), a contrastenhanced multidetector computed tomography was conducted to test for pulmonary embolism (PE). Multidetector computed tomography, however, showed no thrombotic mass in the main and segmental pulmonary arteries but a subpleural wedgeshaped consolidation, rated suspicious for beginning ischemic pneumonia, for example, because of subsegmental embolism, which is commonly missed by conventional multidetector computed tomography (Figure 1). The patient consecutively underwent ventilation and perfusion single-photon emission computed tomography (SPECT), which revealed a mismatch consisting of a perfusion defect in segments 8 and 9 of the left lower lobe but unimpaired ventilation corresponding to PE (Figure 2).After anticoagulation was initiated, the patient was referred to functional lung magnetic resonance imaging (MRI) using Fourier decomposition (FD-MRI) to correlate the findings with this new technique. FD allows for separation of the periodic MR signal changes induced by respiration and pulsatile blood flow in the lungs. Thereby, ventilation and perfusion maps can be generated in free breathing and without application of ionizing radiation or contrast agents. FD-MRI was performed using the SElf-gated Non-Contrast-Enhanced FUnctional Lung (SENCEFUL) MRI approach, providing maps in sufficient spatial resolution and reconstruction of complete cardiac/respiratory cycles.1 The acquisition of a slice with 1-cm thickness in the coronar plane takes ≈2 minutes. Data acquisition of the entire lung amounts to 15 to 20 slices, resulting in an acquisition time of 25 to 40 minutes. Including image postprocessing, the overall examination time amounts to ≈90 minutes, which is comparable with ventilation and perfusion SPECT. SENCEFUL FD-MRI can be implemented in any commercially available MRI system as technical details of the sequence have been published. 1Limitations of FD-MRI refer to the common MRI contraindications. Evaluation and development of SENCEFUL-MRI is part of a research protocol on functional lung MRI in the reporting department.The MRI ventilation maps of the reported patient displayed a physiological distribution of the ventilation without regional impairm...

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supporting

confidence: 83%

Acute Pulmonary Artery Embolism Detected by Noncontrast Functional Lung Magnetic Resonance Imaging

Kestler

Weng

Kunz

et al. 2016

Circ: Cardiovascular Imaging

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“…When Fourier Decomposition MRI was compared with contrast enhanced MRI there was consistency between the images (Fig. 2), with similar patterns of perfusion inhomogeneity [59,60].…”

Section: Non-contrast Enhanced Mri In Cystic Fibrosismentioning

confidence: 72%

Evaluation of high resolution computed tomography findings of cystic fibrosis

Şaşihüseyinoğlu

Altıntaş

Soyupak

et al. 2019

Korean J Intern Med

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Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a clinically relevant functional readout of total lung function, however does not supply any visible or localised information. High Resolution Computed Tomography (HRCT) is a well-established current 'gold standard' method for monitoring lung anatomical changes in Cystic Fibrosis patients. HRCT provides excellent morphological information, however, the X-ray radiation dose can become significant if multiple scans are required to monitor chronic diseases such as cystic fibrosis. X-ray phase-contrast imaging is another emerging X-ray based methodology for Cystic Fibrosis lung assessment which provides dynamic morphological and functional information, albeit with even higher X-ray doses than HRCT. Magnetic Resonance Imaging (MRI) is a non-ionising radiation imaging method that is garnering growing interest among researchers and clinicians working with Cystic Fibrosis patients. Recent advances in MRI have opened up the possibilities to observe lung function in real time to potentially allow sensitive and accurate assessment of disease progression. The use of hyperpolarized gas or non-contrast enhanced MRI can be tailored to clinical needs. While MRI offers significant promise it still suffers from poor spatial resolution and the development of an objective scoring system especially for ventilation assessment.

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“…Swift et al (42) evaluated the potential of dynamic proton MR imaging to obtain lung volumetric measurements by sampling a forced vital capacity maneuver, Bauman et al (19,20) recently proposed a noninvasive method for ventilation and perfusion imaging based on Fourier decomposition MR imaging in free breathing, thus requiring stability of breathing and heart rate during the measurement. We propose an alternative approach, based on the registration of breath-hold multivolume MR images averaged over many heartbeats.…”

Section: Discussionmentioning

confidence: 99%

“…The use of proton MR imaging has historically been hampered by the combination of low proton density and short T2* of lung tissue (14,15), but it has regained attention with the development of short-acquisition-time techniques (16,17) and frequency-swept nuclear MR (18). Enhanced techniques developed with free-breathing MR imaging have been proposed to assess regional ventilation by using Fourier decomposition (19,20) and by using image registration (21,22).…”

Section: Study Subjectsmentioning

confidence: 99%

Assessment of Regional Lung Function with Multivolume¹H MR Imaging in Health and Obstructive Lung Disease: Comparison with³He MR Imaging

Pennati¹,

Quirk²,

Yablonskiy³

et al. 2014

Radiology

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Pulmonary Functional Imaging: Qualitative Comparison of Fourier Decomposition MR Imaging with SPECT/CT in Porcine Lung

Cited by 104 publications

References 22 publications

Acute Pulmonary Artery Embolism Detected by Noncontrast Functional Lung Magnetic Resonance Imaging

Acute Pulmonary Artery Embolism Detected by Noncontrast Functional Lung Magnetic Resonance Imaging

Evaluation of high resolution computed tomography findings of cystic fibrosis

Assessment of Regional Lung Function with Multivolume¹H MR Imaging in Health and Obstructive Lung Disease: Comparison with³He MR Imaging

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Pulmonary Functional Imaging: Qualitative Comparison of Fourier Decomposition MR Imaging with SPECT/CT in Porcine Lung

Cited by 104 publications

References 22 publications

Acute Pulmonary Artery Embolism Detected by Noncontrast Functional Lung Magnetic Resonance Imaging

Acute Pulmonary Artery Embolism Detected by Noncontrast Functional Lung Magnetic Resonance Imaging

Evaluation of high resolution computed tomography findings of cystic fibrosis

Assessment of Regional Lung Function with Multivolume1H MR Imaging in Health and Obstructive Lung Disease: Comparison with3He MR Imaging

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Assessment of Regional Lung Function with Multivolume¹H MR Imaging in Health and Obstructive Lung Disease: Comparison with³He MR Imaging