Pulmonary Hyaline Membranes and the Respiratory Distress Syndrome

Gregg, Robert H.

doi:10.1001/archpedi.1961.02080010873011

Cited by 15 publications

(11 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…12,15 This initial description was followed by ϳ60 years of confusion regarding the pathogenesis, etiology, and nomenclature for the disease. On the basis of autopsies of 8 newborn infants, Johnson and Meyer 16 first described the histologic findings of a "hyaline membrane" that was thought to impair gas exchange.…”

Section: Period 1: Before 1950mentioning

confidence: 99%

“…3 RDS supplanted hyaline membrane disease (an autopsy diagnosis) as the common term to describe the condition seen in 20% to 40% of newborns who died in the first few days of life. 12 Research using RDS-like disease in animal models advanced the understanding of the pathophysiology of the disease. 20 A surface-active material, subsequently called surfactant, was recognized to line the airways and decrease surface tension.…”

Section: Period 2: 1950 -1969mentioning

confidence: 99%

“…20 A surface-active material, subsequently called surfactant, was recognized to line the airways and decrease surface tension. 12,21,22 In 1959, Avery and Mead 23 reported that the amount of surfactant was related to birth weight and maturity, and surfactant was low in the lungs of infants who died of RDS. 12,24 Oxygen was the only available treatment for the hypoxemia of RDS.…”

Section: Period 2: 1950 -1969mentioning

confidence: 99%

“…12,21,22 In 1959, Avery and Mead 23 reported that the amount of surfactant was related to birth weight and maturity, and surfactant was low in the lungs of infants who died of RDS. 12,24 Oxygen was the only available treatment for the hypoxemia of RDS. 24 In the late 1940s, with increased recognition of oxygen toxicity, including retrolental fibroplasia (now called retinopathy of prematurity) and damage to alveoli, 25 clinicians were hesitant to administer oxygen concentrations above 40% to preterm infants.…”

Section: Period 2: 1950 -1969mentioning

confidence: 99%

“…7 The overall mortality rate in larger infants from RDS alone remains high at ϳ40% to 60%, 10,11 which is equivalent to the RDS mortality rate in the United States during the 1950s and 1960s, when oxygen was the only therapy. 12,13 Apart from what is cited here, few current data exist in low-resource settings regarding RDS-specific mortality rates. Therefore, we conducted a historical review to better understand the interventions that have decreased the rates of RDSspecific mortality in high-income countries over the past 60 years.…”

mentioning

confidence: 97%

See 4 more Smart Citations

Neonatal Mortality From Respiratory Distress Syndrome: Lessons for Low-Resource Countries

et al. 2011

View full text Add to dashboard Cite

Respiratory distress syndrome (RDS) is a major contributor to neonatal mortality worldwide. However, little information is available regarding rates of RDS-specific mortality in low-income countries, and technologies for RDS treatment are used inconsistently in different health care settings. Our objective was to better understand the interventions that have decreased the rates of RDS-specific mortality in high-income countries over the past 60 years. We then estimated the effects on RDS-specific mortality in low-resource settings. Of the sequential introduction of technologies and therapies for RDS, widespread use of oxygen and continuous positive airway pressure were associated with the time periods that demonstrated the greatest decline in RDS-specific mortality. We argue that these 2 interventions applied widely in low-resource settings, with appropriate supportive infrastructure and general newborn care, will have the greatest impact on decreasing neonatal mortality. This historical perspective can inform policy-makers for the prioritization of scarce resources to improve survival rates for newborns worldwide.

show abstract

Section: Period 1: Before 1950mentioning

confidence: 99%

Section: Period 2: 1950 -1969mentioning

confidence: 99%

Section: Period 2: 1950 -1969mentioning

confidence: 99%

Section: Period 2: 1950 -1969mentioning

confidence: 99%

mentioning

confidence: 97%

See 3 more Smart Citations

Neonatal Mortality From Respiratory Distress Syndrome: Lessons for Low-Resource Countries

et al. 2011

View full text Add to dashboard Cite

show abstract

Re: Article by Dr. Craig

Gruenwald¹

1964

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

Bradford swab in hand, I feel compelled to defend its use. As Drs. Bales and Yarington state, "Time has proven the effectiveness of such a swab for obtaining nasopharyngeal cultures in children." The hazard which they report, namely inadvertent ingestion, becomes nonexistent if the distal end of the swab is looped in a circle approximately the size of a dime, thus preventing passage through the external nares when the culture is obtained.

show abstract

Respiratory Distress Syndrome and The High Risk Mother

Graven¹,

Misenheimer²

1965

Arch Pediatr Adolesc Med

View full text Add to dashboard Cite

THE EXACT role of maternal factors in the pathogenesis of the respiratory distress syndrome (RDS) remains unresolved despite the availability of considerable statistical data. In a recent review of the experience with the RDS at the Wilford Hall USAF Hospital, it was noted that several mothers delivered successive small infants who developed the RDS. This suggested that the low birth weight infants of some mothers were predisposed to the development of the RDS irrespective of the complications of a particular pregnancy. It is the purpose of this report to present data relevant to this question. Materials and MethodsThe records of all mothers who delivered more than one infant weighing between 900 and 2,500 gm from at the Wilford Hall USAF Hospital were reviewed with the records of their infants. One mother who delivered at the USAF Hospital, Laughlin AFB, Texas, is also included. For purposes of this review, infants weighing between 900 and 2,500 grams were considered to be of low birth weight (LBW). If all LBW infants of an individual mother had severe erythroblastosis, congenital anoma¬ lies incompatible with life, or suffered from asphyxia which resulted in death in the first two hours of life, the mother and the infants were excluded from fur¬ ther consideration. No attempt was made to estimate

show abstract

Pulmonary Hyaline Membranes and the Respiratory Distress Syndrome

Cited by 15 publications

References 101 publications

Neonatal Mortality From Respiratory Distress Syndrome: Lessons for Low-Resource Countries

Neonatal Mortality From Respiratory Distress Syndrome: Lessons for Low-Resource Countries

Re: Article by Dr. Craig

Respiratory Distress Syndrome and The High Risk Mother

Contact Info

Product

Resources

About