Pulmonary hypertension in isolated secundum atrial septal defect: High frequency in young patients

Cherian, G; Uthaman, C. Babu; Durairaj, M; Sukumar, I P; Krishnaswami, S; Jairaj, P. S.; John, Stanley; Krishnaswami, H; Bhaktaviziam, A

doi:10.1016/0002-8703(83)90396-4

Cited by 62 publications

(34 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is consistent with the findings of Roos-Hesselink et al [22]. However, earlier studies described cohorts with severe preoperative pulmonary hypertension, even in children [1,4,9,17,19]. For instance, in Cherian et alÕs.…”

Section: Discussionsupporting

confidence: 89%

“…For instance, in Cherian et alÕs. study of 709 young patients, the incidence of pulmonary hypertension (systolic pulmonary artery pressure >50 mmHg) was 13% in children under 10 years of age [4]. In a study conducted by Murphy et al, the incidence of pulmonary hypertension within the same age group was even higher at 28% (peak systolic pulmonary artery pressure >40 mmHg) [17].…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Long-term Outcome after Surgical Closure of Atrial Septal Defect in Childhood with Extensive Assessment Including MRI Measurement of the Ventricles

et al. 2005

View full text Add to dashboard Cite

Abstract. Surgical closure of the secundum type of atrial septal defect (ASD) in childhood leads to excellent survival. However, relevant morbidity has been reported. Transcatheter closure of these defects has now become an alternative approach. To compare the results of the two different interventions, reliable data are needed on the long-term morbidity after defect closure with both methods. Patients were evaluated after a minimum of 10 years after surgical closure of an ASD in childhood. Assessment included analysis of perioperative data, interview, clinical examination, electrocardiogram, (ECG), 24-hour ECG, ergometry, chest radiograph, echocardiography, and MRI. A total of 66 patients underwent operation between 1971 and 1986 at our institution. Forty-eight of them (73%) were interviewed and 38 (58%) participated fully in the study program. Eighteen (27%) either refused to participate or were lost to follow-up. There were no substantial residual disorders, such as arrhythmias, right-sided heart dilatation, pulmonary hypertension, or reduced work capacity. Surgical closure of an ASD in childhood has an excellent long-term outcome. Surgical closure is thus the standard against which transcatheter closure needs to be measured.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 93%

Long-term Outcome after Surgical Closure of Atrial Septal Defect in Childhood with Extensive Assessment Including MRI Measurement of the Ventricles

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Natural history studies dating to the presurgical and pre-echocardiography eras suggested an incidence of Ϸ15% in the ASD population. 18 The observations that pulmonary vascular disease may develop in patients with a tiny ASD and that it is absent in the vast majority of patients with large ASDs suggest that the ASD may be an associated marker of pulmonary hypertension but not necessarily causative. More recent reviews suggest a rate of 6% to 9%.…”

Section: Natural Historymentioning

confidence: 99%

Pathophysiology of Congenital Heart Disease in the Adult

2008

View full text Add to dashboard Cite

“…[57][58][59][60] Pulmonary vascular disease may occur in up to 5% to 10% of patients with untreated ASDs, predominantly in females. 61 The pathogenesis of the pulmonary arterial hypertension in such patients is unknown, but it does not appear to be caused solely by the magnitude of the shunt persisting for decades.…”

Section: Pulmonary Arterial Hypertensionmentioning

confidence: 99%