Pulmonary hypertension in the newborn- etiology and pathogenesis

Sankaran, Deepika; Lakshminrusimha, Satyan

doi:10.1016/j.siny.2022.101381

Cited by 18 publications

(1 citation statement)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Failure to transition from the fetal to the neonatal period [ 1 , 2 ] with a reduction in pulmonary vascular resistance (PVR) can lead to hypoxemic respiratory failure (HRF) and persistent pulmonary hypertension of the newborn (PPHN) [ 3 ]. HRF and PPHN may be conservatively managed with lung recruitment (with ventilation and surfactant if indicated), oxygen supplementation, inhaled nitric oxide (iNO), and in some cases extracorporeal life support (ECLS).…”

Section: Introductionmentioning

confidence: 99%

Novel scoring tool of hypoxemic respiratory failure and pulmonary hypertension for defining severity of persistent pulmonary hypertension of newborn

Timberline,

Bhatt,

Sunderji

et al. 2023

J Perinatol

Self Cite

View full text Add to dashboard Cite

Objective To obtain preliminary validity data for a hypoxemic respiratory failure/pulmonary hypertension (HRF/PH) score for classifying persistent pulmonary hypertension of the newborn (PPHN). Study design Retrospective chart review of 100 consecutive neonates admitted to a Children’s hospital from 2016–2021 with PPHN, gestational age ≥34 weeks, and echocardiograms in the first week. We assessed the correlation between HRF/PH score and short-term outcomes using linear and logistic regressions. Results HRF/PH scores ranged 2–12 (mean 8.5), and were classified mild (0–5), moderate (6–10), and severe (11–15), with 6%, 77% and 17% infants in respective categories. HRF/PH score category correlated with invasive ventilation, nitric oxide, high frequency ventilation, vasoactive infusions, extracorporeal life support and death. HRF/PH score category did not correlate with duration of support or length of stay. Conclusion The HRF/PH score offers a promising representation of disease severity for PPHN. The tool requires further validation in prospective studies and evaluation for long-term outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%