Pulmonary infections

Daltro, Pedro; Santos, Eloá Nunez; Gasparetto, Taísa Davaus; Ucar, María Elena; Marchiori, Edson

doi:10.1007/s00247-011-2012-8

Cited by 32 publications

(26 citation statements)

References 45 publications

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“…Severe interstitial pneumonia of viral, particularly CMV, etiology in an infant, apart from lymphopenia and hypogammaglobulinemia, should alert physicians to the significance of signs which might suggest the presence of this life-threatening immune deficiency. While the chest X-ray and HRCT imaging findings are usually non-specific, the patient's age and the immune status correlate with the etiology of pneumonia and limit the spectrum of differential diagnoses [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical immunology Cytomegalovirus pneumonia as the first manifestation of severe combined immunodeficiency

Szczawińska-Popłonyk¹,

Jończyk‐Potoczna²,

Ossowska³

et al. 2014

cejoi

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Severe combined immunodeficiency (SCID) is characterized by the absence of functional T lymphocytes and impairment of adaptive immunity. While heterogeneity of the genetic background in SCID leads to the variability of immune phenotypes, most of affected newborns appear healthy but within the first few months they develop life-threatening opportunistic respiratory or gastrointestinal tract infections. The objective of the study was to define the presenting features and etiology of infections in children with SCID. We retrospectively reviewed five children in whom the diagnosis of SCID had been established in our pediatric immunology clinic over the last 10-year period. A viral respiratory tract infection was the first manifestation of SCID in all the children studied. Cytomegalovirus (CMV) pneumonia was recognized in as many as 4 cases and coronavirus pulmonary infection was diagnosed in one case, whereas Pneumocystis jiroveci was identified as a co-pathogen in one CMV-infected patient. Severe combined immunodeficiency is a pediatric emergency condition and given the significant impact of pulmonary CMV infection in SCID children, establishing an accurate etiological diagnosis is of essential importance in instituting the specific treatment and improving the outcome.

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Section: Discussionmentioning

confidence: 99%

Clinical immunology Cytomegalovirus pneumonia as the first manifestation of severe combined immunodeficiency

Szczawińska-Popłonyk¹,

Jończyk‐Potoczna²,

Ossowska³

et al. 2014

cejoi

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“…Bu nedenle akciğer radyografisi ile birlikte klinik ve laboratuvar bulguların birleştirilmesi halen en değerli tanı yöntemidir [18,22]. Dünya Sağlık Örgütü'nün (WHO) asıl olarak gelişmemiş ve gelişmekte olan ülkelerde epidemiyolojik uygulamalar için geliştirdiği takipne üzerine belirlenmiş kriterler modern yaklaşımda yetersiz kalmaktadır [23]. Radyografi pnömoni tanısını doğrulamak, enfeksiyon ajanını tahmin etmek, semptomlara yol açan diğer nedenleri dışlamak, tedavi başarısızlığını açıklamak ve komplikasyonları değerlendirmek için kullanılır.…”

Section: Akciğer Enfeksiyonuunclassified

Normal ve Patolojik Pediatrik Akciger ve Toraks Radyografisi

Aslan¹,

Yıkılmaz²

2017

Trd Sem

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“…For example, the World Health Organisation states that pneumonia is responsible for the deaths of 1.1 million children under 5 years old every year. While vaccines for viral and bacterial pulmonary infections exist or are under development, [60] these tend to be delivered in the 'traditional' method by intramuscular or subcutaneous injection and several have a limited efficacy. Development of an inhaled form of vaccine may improve protective responses and, importantly, may also increase patient compliance [61] and therefore enhance health outcomes overall by promoting 'herd immunity' .…”

Section: Considerations For Delivery By the Pulmonary Routementioning

confidence: 99%

Developing accurate models of the human airways

Marshall

Oguejiofor

Willetts

et al. 2015

Journal of Pharmacy and Pharmacology

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Objectives Particle delivery to the airways is an attractive prospect for many potential therapeutics, including vaccines. Developing strategies for inhalation of particles provides a targeted, controlled and non-invasive delivery route but, as with all novel therapeutics, in vitro and in vivo testing are needed prior to clinical use. Whilst advanced vaccine testing demands the use of animal models to address safety issues, the production of robust in vitro cellular models would take account of the ethical framework known as the 3Rs (Replacement, Reduction and Refinement of animal use), by permitting initial screening of potential candidates prior to animal use. There is thus a need for relevant, realistic in vitro models of the human airways. Key findings Our laboratory has designed and characterised a multi-cellular model of human airways that takes account of the conditions in the airways and recapitulates many salient features, including the epithelial barrier and mucus secretion. Summary Our human pulmonary models recreate many of the obstacles to successful pulmonary delivery of particles and therefore represent a valid test platform for screening compounds and delivery systems. Developing relevant, accurate models of human airwaysThis article aims to consider the features of the human airways that it is possible to develop using in-vitro cell culture methods and how our laboratory is focused on increasing the complexity of cellular models. To do this, we will firstly consider the anatomy of the normal human airways and which features we are able to effectively mimic in the lab.

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Pulmonary infections

Cited by 32 publications

References 45 publications

Clinical immunology Cytomegalovirus pneumonia as the first manifestation of severe combined immunodeficiency

Clinical immunology Cytomegalovirus pneumonia as the first manifestation of severe combined immunodeficiency

Normal ve Patolojik Pediatrik Akciger ve Toraks Radyografisi

Developing accurate models of the human airways

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