Pulmonary involvement in inflammatory bowel disease

Yılmaz, Aydın; Demirci, Nilgün Yılmaz; Hoşgün, Derya; Üner, Enver; Erdoğan, Yurdanur; Gökçek, Atila; Çağlar, Atalay

doi:10.3748/wjg.v16.i39.4952

Cited by 65 publications

(88 citation statements)

References 21 publications

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“…Tzanakis et al 5. found alteration in the function of small airways independent of the presence of atopy in patients with UC even without pulmonary symptoms.…”

Section: Discussionmentioning

confidence: 98%

“…Since its first report, abnormal pulmonary function tests (PFTs) have been reported in 17–55% patients with UC,2, 3, 4, 5, 6 including a decrease in gas transfer factor (diffusion lung capacity for carbon monoxide [DLCO]),7, 8 elevated functional residual capacity (FRC),9 decrease in maximal mid‐expiratory flow rate (MEFR),10 or an increased frequency of bronchial hyperresponsiveness11; however, in some studies, no abnormalities in PFT were found 10, 12. Various respiratory abnormalities reported in patients with UC include obstructive and interstitial lung disease,13 small and large airway disorders,14, 15 increase in bronchial sensitivity,11 bronchitis, bronchiectasis,16, 17 and bronchiolitis oblitrans 18.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

et al. 2017

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Background and AimUlcerative colitis (UC) patients have several extraintestinal and systemic manifestations. As studies on the frequency and predictors of pulmonary involvement in patients with UC are inconsistent, we undertook this prospective study.MethodsEighty‐seven patients with UC (in remission 49, 56.3%, active disease 38, 43.6%, median age: 40 years, range: 16–66, 55, 62.2% males) and 50 healthy controls (median age: 38 years, range: 14–69, 34, 68% males) underwent pulmonary function tests (PFTs) including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), Tiffeneau value (FEV1/FVC), mid‐expiratory flow rate, and diffusion lung capacity for carbon monoxide with spirometer.ResultsSubjects with UC and control were comparable in age and gender. PFT was abnormal in 24 (27.5%) patients (active disease 15/38, 39.4%, remission 9/49, 18.4%) and 1 (2%) control (P < 0.005). Of the 24 patients with abnormal PFT, small airway, restrictive, and obstructive defects were detected in 12 (50%), 11 (45.8%), and 1 (4.2%) patients, respectively. Patients with abnormal PFT more often had active disease (15/24, 62.5% vs 23/63, 36.5%; P = 0.03). No relation of PFT abnormalities was found with age, sex, duration of disease, body mass index, serum albumin, and hemoglobin levels, and other extraintestinal manifestation (arthritis/arthralgia) and drugs used to treat UC.ConclusionUC patients with active disease have abnormal pulmonary functions with predominant involvement of small airways. Active UC was more often associated with abnormal PFT than the disease in remission.

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“…Tzanakis et al 5. found alteration in the function of small airways independent of the presence of atopy in patients with UC even without pulmonary symptoms.…”

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

et al. 2017

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“…In one of the studies, a group of IBD patients had significantly lower mean DLCO and higher ratio of residual volume (RV) to total lung capacity (TLC) than a control group [23]. In another study, mean values of forced expiratory volume in one second (FEV 1 ), ratio of FEV 1 to forced vital capacity (FVC), maximum mid-expiratory flow (MMEF), DLCO, and carbon monoxide transfer coefficient (K co ) were lower in IBD patients than in healthy subjects [26]. Abnormalities in PFT could be found even in nonsmoking IBD patients with no history of respiratory tract disorder and with normal chest x-ray [28].…”

Section: Epidemiologymentioning

confidence: 99%

“…Patients with CD were 1.4-3.0 times more likely to report respiratory symptoms than patients with UC. Other studies showed that respiratory symptoms were reported by 26-48% of IBD patients, which was more frequent than in healthy people [23][24][25][26][27].…”

Section: Epidemiologymentioning

confidence: 99%

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Respiratory System Involvement in Inflammatory Bowel Diseases

Kacprzak¹,

Szturmowicz²,

Kuś³

2017

Advances in Respiratory Medicine

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Increased risk of obstructive lung disease in inflammatory bowel disease: A population‐based cohort study

Jacobsen,

Karachalia Sandri,

Weinreich

et al. 2024

UEG Journal

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Background and AimsInflammatory bowel disease (IBD) is associated with disease manifestations in organs other than the gastrointestinal tract. In this study, we aimed to estimate the odds of obstructive lung disease (OLD) before IBD onset and the risk of OLD after IBD onset.MethodsIn a nationwide population‐based Danish cohort study from 1999 to 2018, individuals with IBD and OLD were identified using the Danish registries. Between 2003 and 2013, 24,238 individuals with IBD were identified and matched 1:10 with non‐IBD individuals. Logistic regression was used to estimate the prevalence odds ratio for OLD before IBD onset. Time‐to‐event analysis was performed to explore the risk of OLD after IBD onset. In a sensitivity analysis, the time‐to‐event analysis was repeated using the composite outcome OLD and the separate outcomes, chronic obstructive pulmonary disease (COPD), asthma, and bronchiectasis.ResultsIndividuals with IBD were 60% more likely to have OLD before onset (adjusted odds ratio: 1.60, 95% confidence interval [CI]: 1.53–1.67). Furthermore, their risk of OLD was more than 40% higher after IBD diagnosis (adjusted hazard ratio [aHR]: 1.43, 95% CI: 1.37–1.49). The sensitivity analysis increased the risk to 60% (aHR: 1.63, 95% CI: 1.53–1.73). Similar results were found for COPD and asthma separately, whereas the risk of bronchiectasis increased more than 2‐fold (aHR: 2.44, 95% CI: 1.91–3.11).ConclusionThe odds of OLD before‐ and the risk following an IBD diagnosis were increased. We encourage physicians to be vigilant of pulmonary symptoms in persons with IBD and gastrointestinal symptoms in individuals with OLD.

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Pulmonary involvement in inflammatory bowel disease

Abstract: It is important that respiratory manifestations are recognized and treated early in IBD. Otherwise, they can lead to destructive and irreversible changes in the airway wall.

Cited by 65 publications

References 21 publications

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

Respiratory System Involvement in Inflammatory Bowel Diseases

Increased risk of obstructive lung disease in inflammatory bowel disease: A population‐based cohort study

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