Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases

Mestre, Tiago; Rodrigues, Ana Maria; Cardoso, Jorge

doi:10.1590/s1806-37132015000004500

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…Our patient had three metachronous primary malignancies and the last one is very rare. Only two cases of multiple cutaneous metastases of LCNEC have been reported in the literature [9,10]. Also, this is first case of three primary malignancies which include pulmonary LCNEC with multiple cutaneous metastases in the literature which makes it intersting.…”

Section: Neuroendocrine Tumors (Net) Category Constitutes An Importanmentioning

confidence: 79%

Large Cell Neuroendocrine Carcinoma of The Lung with Skin Metastasis and Multiple Metachronous Primaries

İçlı¹

2017

OAJCO

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Section: Neuroendocrine Tumors (Net) Category Constitutes An Importanmentioning

confidence: 79%

Large Cell Neuroendocrine Carcinoma of The Lung with Skin Metastasis and Multiple Metachronous Primaries

İçlı¹

2017

OAJCO

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“…Cases of skin (cutaneous/subcutaneous) metastases derived from neuroendocrine tumors of the lung [3][4][5][6][7][8], gastrointestinal [2,[9][10][11] and genitourinary tract [12][13][14][15] as well as of other origins or with unknown primary tumor site [16][17][18] have been exceptionally reported. In line with observations and revisions by Amorim et Al.…”

Section: Discussionmentioning

confidence: 99%

Unexpected response to palliative radiotherapy for subcutaneous metastases of an advanced small cell pancreatic neuroendocrine carcinoma: a case report of two different radiation schedules

Ciliberti¹,

Carbonara

Grillo³

et al. 2020

BMC Cancer

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Background: Skin metastases from pancreatic neuroendocrine carcinoma (PNEC) are rare and their palliative treatment is challenging. We report our experience in the multimodal management of one of the few reported cases of metastatic PNEC with multiple visceral and subcutaneous secondary lesions, focusing on the effectiveness of palliative radiotherapy for skin metastases. Case presentation: A 61-years old woman affected by a metastatic PNECwith subcutaneous growing and bleeding secondary lesions (at the scalp, right scapular region and at the back of the left thoracic wall, respectively) obtained a successful control of visceral metastases with the use of chemotherapy and an unexpected local response of her skin metastases with palliative radiotherapy. In particular, two subsequent radiation treatments were performed using different fractionation schedules (30 Gy in 10 fractions and 20 Gy in 5 fractions, respectively). Both radiation treatments were well-tolerated and patient's quality of life was improved. Local response was maintained until patient's deaththat occurred due to cachexia. Conclusions: The presented case highlights the effectiveness and the good tolerance of radiotherapy in the treatment of subcutaneous metastases; nevertheless, further knowledge of the optimal local palliative approach for PNEC metastatic sites is necessary. The experience gained in this work is the occasion to encourage a routine integrated multidisciplinary team management of metastatic PNECs because of their clinical complexity. The aim is to guarantee the optimization of the care with personalized and more effective systemic and local treatmentsalso including supportive cares and treatment-related side effects management.

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“…Homeobox transcription factor CSX-2 correlates well with tumors derived from the intestines, whereas TTF-1 correlates with tumors derived from the lungs [5]. Cutaneous metastatic neuroendocrine carcinoma is rare and has, to the best of our knowledge, been reported in only 42 cases [5][6][7][8].…”

Section: Introductionmentioning

confidence: 98%

Metastatic neuroendocrine carcinoma in the skin

Garcia

Mays²,

Silapunt³

2017

Dermatology Online Journal

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Pulmonary large-cell neuroendocrine carcinoma presenting as multiple cutaneous metastases

Cited by 5 publications

References 4 publications

Large Cell Neuroendocrine Carcinoma of The Lung with Skin Metastasis and Multiple Metachronous Primaries

Large Cell Neuroendocrine Carcinoma of The Lung with Skin Metastasis and Multiple Metachronous Primaries

Unexpected response to palliative radiotherapy for subcutaneous metastases of an advanced small cell pancreatic neuroendocrine carcinoma: a case report of two different radiation schedules

Metastatic neuroendocrine carcinoma in the skin

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