Pulmonary Lymphomatoid Granulomatosis in a Dog: Evidence of Immunophenotypic Diversity and Relationship to Human Pulmonary Lymphomatoid Granulomatosis and Pulmonary Hodgkin's Disease

Park, H. M.; Hwang, Du Na; Kang, Bing; Jung, DaeSoo; Song, Geun Seog; Lee, S. J.; Yhee, Ji Young; Yu, Chi Ho; Doster, Alan R.; Sur, Jung-Hyang

doi:10.1354/vp.44-6-921

Cited by 18 publications

(27 citation statements)

References 9 publications

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“…The immunophenotypic findings indicated that AIL in the cat in the current study was of both B-and T-cell lineages, and these findings correlated with those reported for 1 case of canine pulmonary AIL 18 and for other types of canine lymphoma. 20,23,24 These findings were in contrast to human AIL, where most cases have been classified as Tcell-rich B-cell lymphomas.…”

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confidence: 90%

Metastatic Angioinvasive Lymphoma (Lymphomatoid Granulomatosis) in a Cat

Rogers¹,

Aliano

2009

J VET Diagn Invest

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Abstract. A subcutaneous mass removed from the right rear leg of a 17-year-old, spayed, female Domestic Shorthair cat was characterized histopathologically by granulomatous inflammation, sheets of large atypical lymphoid cells, and necrosis. The walls of the small and medium caliber blood vessels were invaded transmurally by atypical lymphoid cells. A diagnosis of angioinvasive lymphoma (AIL), or lymphomatoid granulomatosis, was made based on histopathologic findings. The cat was euthanized 2 months later because of recurrence of the mass and elevated serum alanine aminotransferase activity, and a necropsy was performed. The histopathologic lesion of AIL was seen in the skin and subcutis of the right rear leg, and neoplastic cell infiltrates were seen in adjacent skeletal muscle, right superficial inguinal lymph node, liver, and spleen. By immunohistochemistry, variable numbers of neoplastic cells expressed B-lymphocyte antigen 36 (BLA36) or cluster of differentiation (CD)3 markers, indicative of B-and T-cell lineages, respectively. Neoplastic cells were uniformly positive for vimentin and uniformly negative for cytokeratins and myeloid/histiocytic antigen. Although the cat had received a Rabies virus vaccine subcutaneously in the right rear leg 6 months earlier, the AIL lesion was not typical of vaccine-induced sarcomas. The AIL in this cat was unusual because the extrapulmonary metastases involved the skin and subcutis.

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confidence: 90%

Metastatic Angioinvasive Lymphoma (Lymphomatoid Granulomatosis) in a Cat

Rogers¹,

Aliano

2009

J VET Diagn Invest

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“…There was no evidence of hepatomegaly or splenomegaly. A complete blood count showed abnormal leukocytosis (40,100 cell/µl; reference range 6,000 to 17,000/µl) with mature neutrophilia (23,258 cell/µl; reference range 3,000 to 11,500 /µl) and lymphocytosis (16,441 cell/µl reference range 1,000 to 4,800/µl). The blood biochemical findings included an increased total protein concentration (8.4 g/dl) with a high globulin concentration (A/ G=0.5).…”

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confidence: 99%

“…The phenotype of canine LYG is now controversial because immunohistochemical analyses of the canine LYG have been documented in only a few papers [14,16,20]. In one report, canine LYG has been associated with malignant T-cell type lymphocytes and is considered a T-cell lymphoma [20].…”

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confidence: 99%

“…Moreover, the presence of clonally expanded T-cell was revealed by polymerase chain reaction (PCR) in a CD3-positive canine cutaneous LYG, recently [19]. The other report of a pulmonary case, however, showed that there were both CD3 positive T cells and CD79 positive B cells [16]. The immunophenotypic analysis showed that canine cutaneous LYG had both neoplastic T-and B-cells [14].…”

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confidence: 99%

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Successful Management with CHOP for Pulmonary Lymphomatoid Granulomatosis in a Dog

Hatoya

Kumagai

Takeda

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. A 3-year-old, spayed female miniature dachshund was presented for vomiting and anorexia. Thoracic radiographs and CT scan revealed abnormal pulmonary opacities at bilateral caudal lobe. Cytological analysis of the pulmonary mass revealed the presence of large lymphohistiocytic cells and small lymphocytes with occasional neutrophils and plasma cells. An open lung biopsy was performed and a diagnosis of pulmonary lymphomatoid granulomatosis (LYG) was made. The dog was administered CHOP based therapy (modified UW-25), and it survived for 1,022 days after admission. Immunohistochemistry revealed pulmonary lesions consisted of many CD79a positive B cells aggregation and proliferation with prominent angiocentric pattern. This was the first case of canine pulmonary LYG managed by CHOP chemotherapy.KEY WORDS: canine, CHOP, lymphomatoid granulomatosis, pulmonary.J. Vet. Med. Sci. 73(4): 527-530, 2011 Lymphomatoid granulomatosis (LYG) is a unique form of pulmonary angiitis and granulomatosis which was first described by Liebow et al. in 1972 [12]. Histologically it is a necrotizing angiocentric and angiodestructive infiltrative process composed of small lymphocytes, plasma cells, histiocytes and atypical lympho-reticular cells [11,12]. In veterinary medicine, canine pulmonary LYG is a rare pulmonary lymphoproliferative disease; very few treatment studies have been conducted and no standard treatment is established [2,17]. In this report, we describe clinical and pathological findings of a canine LYG, which results in long-term survive with CHOP therapy, modified version of the University of Wisconsin-Madison (UW-25) protocol for canine lymphoma [7].A 3-year-old, spayed female miniature dachshund, weighing 3.5 kg, was presented to Osaka Prefecture University Veterinary Clinical Center for 4 week-history of vomiting and anorexia. Clinical examination revealed pyrexia and dyspnea. A peripheral lymphadenopathy was not recognized. There was no evidence of hepatomegaly or splenomegaly. A complete blood count showed abnormal leukocytosis (40,100 cell/µl; reference range 6,000 to 17,000/µl) with mature neutrophilia (23,258 cell/µl; reference range 3,000 to 11,500 /µl) and lymphocytosis (16,441 cell/µl reference range 1,000 to 4,800/µl). The blood biochemical findings included an increased total protein concentration (8.4 g/dl) with a high globulin concentration (A/ G=0.5). Increased α-2 and γ fraction were identified via serum electrophoresis. The dog was negative for Dirofilaria immitis infestation. Thoracic radiographs revealed abnormal pulmonary opacities at bilateral caudal lobe (Fig. 1). Radiographic evidence of sterna lymphadenopathy was also noted. A chest computed tomographic (CT) scan of the thorax showed bilateral, wedge-shaped opacities (Fig. 2). Cytological analysis of the pulmonary mass, which was performed by fine-needle aspiration revealed the presence of large lymphohistiocytic cells and small lymphocytes with occasional neutrophils and plasma cells. The dog was treated with Enrofloxacin (5 mg/kg po ...

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“…The present study could not examine the particular immunophenotype (CD4, CD8, TCRαβ and TCRγδ) of neoplastic T-cell lymphocytes, as fresh specimens of the tumor were unavailable. No reports have described tumor cell expression for CD4 or CD8 in canine vasotropic and vasoinvasive nonepitheliotropic lymphoma, although CD4-positive cells are reportedly dominant in human cases [10,11]. As a result, the neoplastic vascular invasion and destruction observed in this case caused ischemic necrosis of neoplastic and non-neoplastic tissues in the skin, representing a characteristic feature of vasotropic and vasoinvasive nonepitheliotropic lymphoma.…”

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confidence: 78%

A Case of Canine Vasotropic and Vasoinvasive Nonepitheliotropic Lymphoma with Unusual Tumor Cells and Extensive Dermal Necrosis

Yasuno

Sato

Kariya

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. A 14-year-old, spayed female Shih-tzu dog presented with masses in the dorsal aspect of cervical region and digit of the right anterior limb. Extensive necrosis was seen in the dermal tissue overlying the tumor, and diffuse round cell proliferation and infiltration were seen histologically from the superficial dermis to the deep dermis. Two types of proliferating cells were present: lymphoblast-like cells with round-oval, vesicular nuclei and moderate-large nucleoli; and smaller cells with characteristic irregularly shaped nuclei. Electron microscopy of these smaller cells showed cerebriform, pleomorphic nuclei with a chromatin pattern characteristic of lymphoid cells, as seen in lymphoblast-like tumor cells. Immunohistochemically, both types of tumor cells were positive for CD3. Most vessel walls had been invaded by tumor cells, resulting in extensive dermal necrosis and hemorrhage. Based on these histopathological findings, the tumor was diagnosed as vasotropic and vasoinvasive nonepitheliotropic lymphoma, characterized by a notable presence of unusual tumor cells with irregularly shaped nuclei and extensive dermal necrosis. KEY WORDS: canine, vasotropic and vasoinvasive nonepitheliotropic lymphoma.

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Pulmonary Lymphomatoid Granulomatosis in a Dog: Evidence of Immunophenotypic Diversity and Relationship to Human Pulmonary Lymphomatoid Granulomatosis and Pulmonary Hodgkin's Disease

Cited by 18 publications

References 9 publications

Metastatic Angioinvasive Lymphoma (Lymphomatoid Granulomatosis) in a Cat

Metastatic Angioinvasive Lymphoma (Lymphomatoid Granulomatosis) in a Cat

Successful Management with CHOP for Pulmonary Lymphomatoid Granulomatosis in a Dog

A Case of Canine Vasotropic and Vasoinvasive Nonepitheliotropic Lymphoma with Unusual Tumor Cells and Extensive Dermal Necrosis

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