Pulmonary metastases in children: The place of surgery A study of 134 patients

Baldeyrou, P; Lemoine, G; Zucker, J. M.; Schweisguth, O

doi:10.1016/s0022-3468(84)80430-3

Cited by 29 publications

(8 citation statements)

References 15 publications

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“…6,8,9 Previous reports have advocated surgical removal of lung metastases of osteosarcoma with good results. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The best results reported have fol- lowed the combination of pulmonary resection and adjuvant chemotherapy. 9,14,16,21,27,29 Many factors have been investigated for correlation with survival after pulmonary metastasectomy, including age, sex, primary tumor location, diseasefree interval, tumor-doubling time, bilaterality, resectability, and number of pulmonary nodules.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The best results reported have fol- lowed the combination of pulmonary resection and adjuvant chemotherapy. 9,14,16,21,27,29 Many factors have been investigated for correlation with survival after pulmonary metastasectomy, including age, sex, primary tumor location, diseasefree interval, tumor-doubling time, bilaterality, resectability, and number of pulmonary nodules. 9,10,12,[14][15][16][17][18][19]21,[23][24][25][26][27][28] This study was conducted to compare clinical behaviors of osteosarcomas having lung metastases at initial presentation, those that develop metastases during chemotherapy treatment, and those that develop metastases after the completion of treatment regimen.…”

Section: Discussionmentioning

confidence: 99%

“…9,14,16,21,27,29 Many factors have been investigated for correlation with survival after pulmonary metastasectomy, including age, sex, primary tumor location, diseasefree interval, tumor-doubling time, bilaterality, resectability, and number of pulmonary nodules. 9,10,12,[14][15][16][17][18][19]21,[23][24][25][26][27][28] This study was conducted to compare clinical behaviors of osteosarcomas having lung metastases at initial presentation, those that develop metastases during chemotherapy treatment, and those that develop metastases after the completion of treatment regimen. Although the effect of timing of pulmonary metastases on survival of osteosarcoma patients was not previously studied, controversy existed in the literature about the prognosis of patients having metastasis at initial presentation.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Timing of Pulmonary Metastases Identification on Prognosis of Patients With Osteosarcoma: The Japanese Musculoskeletal Oncology Group Study

Tsuchiya

Kanazawa

Abdel-Wanis

et al. 2002

JCO

151

102

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Time of identification of lung metastasis is an important prognostic factor. In terms of clinical behavior, groups 2 and 3 are completely different than group 4. These data ensure the need to stratify stage III osteosarcomas into subgroups according to the time of diagnosis of lung metastases. To improve the survival of osteosarcoma patients, new treatment modalities should be introduced into the treatment armamentarium for lung metastasis from osteosarcoma, especially in groups 1, 2, and 3.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Timing of Pulmonary Metastases Identification on Prognosis of Patients With Osteosarcoma: The Japanese Musculoskeletal Oncology Group Study

Tsuchiya

Kanazawa

Abdel-Wanis

et al. 2002

JCO

151

102

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“…Thoracotomy is a safe and simple procedure with low operative mortality and few complications in children. Therefore, it is widely used for the treatment of various congenital or acquired pulmonary diseases including primary or metastatic malignant conditions confined to the thoracic cavity (1). Since most of the metastases are located peripherally in the lung, thoracoscopic removal of these lesions is also possible in childhood.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Metastases in Children: An Analysis of Surgical Spectrum

Karnak

Şenocak²,

Kutluk³

et al. 2002

Eur J Pediatr Surg

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Pulmonary surgery is frequently used for the treatment of metastasis or nodules in children with various types of malignancies. However, the indications and effectiveness of pulmonary metastatectomy have not been evaluated recently. Therefore, a retrospective study was conducted to analyse the results of pulmonary metastatectomy in children. Children who underwent pulmonary metastatectomy at our department between 1990 and 2000 were reviewed. Eighteen children consisting of 11 boys and 7 girls (age range, 3 to 18 years) underwent thoracotomy for pulmonary metastasis excision. The primaries were osteosarcoma (n = 2), synovial sarcoma (n = 1), fibrosarcoma (n = 1), Ewing's sarcoma (n = 2), mesenchymal chondrosarcoma (n = 1), Wilms' tumour (n = 4), clear-cell sarcoma (n = 1), Hodgkin lymphoma (n = 3), hepatoblastoma (n = 1), hepatocellular carcinoma (n = 1) and haemangioendotheliosarcoma (n = 1). Pulmonary metastases were encountered either at the time of initial diagnosis (22 %) or occurred within 6 months to 5 years. They were frequently nodular (94 %), unilateral (94 %) and located in the right lung (70 %). The number of metastases were frequently one (56 %) or two (28 %). Excision was done by means of wedge resection (88 %), segmentectomy (6 %), and lobectomy + wedge resection (6 %). The nodules contained tumour cells in most cases (n = 14) (78 %), mature nephrogenic elements (6 %) and no tumour tissue (16 %) in the remaining cases. Histology was similar to that of the original tumour in 12 cases. However, synovial sarcoma was encountered in metastasis in one case with fibrosarcoma primary. Re-thoracotomy was performed in 22 % of cases for the recurrent lesion, which in only one case was a true local recurrence. Overall disease-free survival rate was 56 % during the follow-up period (mean, 36.4 +/- 31.8 months). Pulmonary metastatectomy may increase survival in carefully selected children, though it is unlikely to cure the patient. Therefore combined therapies such as chemotherapy and/or radiotherapy should be continued in the postoperative period.

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“…Baldeyrou studied 134 children with pulmonary metastases from various primary tumor types [24]. While he recommended surgical excision as the initial treatment for a solitary lung metastasis, he was not enthusiastic about the use of surgery in patients who had relapsed after receiving prior treatment for metastatic disease.…”

Section: Review Of the Literature A N D Current Experiencementioning

confidence: 99%