Pulmonary metastasised extraskeletal osteosarcoma

Bots, Eva M T; Wismans, Pieter J.; Slobbe, Lennert

doi:10.1136/thoraxjnl-2015-207657

Cited by 4 publications

(9 citation statements)

References 2 publications

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“…Therefore, the incidence of primary osteosarcoma occurring in the lung and pulmonary artery is even rarer. Unlike osteogenic osteosarcoma, which affects patients in the second decade of life, extraskeletal osteosarcoma has an older average onset age and is slightly more common in males than in females (3,5). The most common site for extraskeletal osteosarcoma is the thigh, followed by the upper extremities and retroperitoneum, but the most extraordinary site is the lung (6, 7).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Primary Extraskeletal Osteosarcoma in the Lung and Pulmonary Artery

Zhai

Fan

et al. 2021

Front. Oncol.

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Extraskeletal osteosarcoma is an uncommon and high-grade soft tissue malignancy. The incidence is even lower when the lung and pulmonary artery are the primary site. The purpose of this report is to present the radiological features of this neoplasm in a 52-year-old man. In our case, contrast-enhanced CT and 3D-CT reconstruction clearly showed the primary lesion and its invasion into surrounding tissues. Although wide local excision of the primary tumor is the treatment of choice, local recurrence and metastasis rates remain high, and this progression can be clearly shown on CT and SPECT/CT examinations.

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Section: Discussionmentioning

confidence: 99%

Case Report: Primary Extraskeletal Osteosarcoma in the Lung and Pulmonary Artery

Zhai

Fan

et al. 2021

Front. Oncol.

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“…There have been few reported cases of ESOS in the literature with only 300 cases reported since it was first described by Wilson in 1941 1 8 . Although the lower extremities and retroperitoneum are common sites, ESOSs have been reported in other organs such as the larynx, esophagus, breast, liver, duodenum, kidney, urinary bladder, orbit, and skin 1 4 5 7 10 . However, a pancreatic ESOS has not yet been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…In one case series, the median survival time was measured as 8 months for metastatic ESOSs with doxorubicin-based chemotherapy 8 . Metastases commonly occur in the lungs, bones, lymph nodes, brain, liver, and skin 4 . Metastasis to the skin is an exceedingly rare and known to be a sign of widespread metastases 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Extraskeletal osteosarcoma (ESOS) is an aggressive mesenchymal soft-tissue neoplasm accounting for 1% of all soft-tissue sarcomas and 2% to 5% osteosarcomas 1 2 3 . It can be diagnosed when the soft-tissue tumor appears with osteoid or cartilage matrix in a sarcomatous pattern but lacks any underlying bony connection 4 . Unlike osteosarcoma of the bone, which mainly occurs during the first two decades of life, this rare tumor occurs equally in both men and women in the fifth and sixth decades of life with a median age of 66 years 2 4 .…”

Section: Introductionmentioning

confidence: 99%

“…It can be diagnosed when the soft-tissue tumor appears with osteoid or cartilage matrix in a sarcomatous pattern but lacks any underlying bony connection 4 . Unlike osteosarcoma of the bone, which mainly occurs during the first two decades of life, this rare tumor occurs equally in both men and women in the fifth and sixth decades of life with a median age of 66 years 2 4 . Trauma and radiation therapy are well-known predisposing factors in the development of around 10% ESOS patients 5 .…”

Section: Introductionmentioning

confidence: 99%

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Pancreatic Extraskeletal Osteosarcoma Metastasizing to the Scalp

Kim

Won

et al. 2018

Ann Dermatol

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Extraskeletal osteosarcoma (ESOS) is a rare mesenchymal soft-tissue neoplasm that accounts for approximately 1% of all soft-tissue sarcomas. Over 70% of these malignant tumor progress to local recurrence and metastasis. It commonly metastasizes to the lungs, lymph nodes, bone, and skin and has a poor survival outcome. Cutaneous metastasis is exceedingly rare and known to be a sign of widespread metastases. We present a 57-year-old woman who presented with a rapidly growing protuberant mass on the scalp that was finally diagnosed as metastatic ESOS from a primary pancreatic ESOS. To our knowledge, there has been no reported case of pancreatic ESOS metastasizing to the scalp.

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Case report: A case of primary renal osteosarcoma

Su,

Fu,

Mao

2024

Medicine

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Rationale: Primary renal osteosarcoma is an exceedingly rare malignant tumor. Fewer than 30 cases have been reported in the literature since 1936. Furthermore, it has a high risk of metastasis and a poor overall prognosis rate. Patient’s concerns: In this report, we present a case of osteosarcoma originating from the left kidney (21 cm × 18 cm × 11 cm) with adhesions of the descending colon mesentery and the abdominal wall. A 63-year-old male patient presented with flank pain and gross hematuria. Diagnoses: A computed tomography scan revealed that the lesion with irregular margins was observed at the lower pole of the left kidney. Enhanced CT scan showed significant inhomogeneous enhancement of the lesion, with non-enhancing necrotic areas. A radical nephrectomy was performed. The immunohistochemistry results support the diagnosis of osteosarcoma. Interventions: Postoperatively, the patient participated in clinical trials and received treatment with a PD-1 antibody (2 weeks/once). Outcomes: At the one-year follow-up, the patient reported late-stage systemic cancer-related pain, necessitating daily pain relief medication. Unfortunately, the patient passed away 18 months after the surgery. Lessons: The case reported here is an exceedingly rare malignant osteosarcoma that originated from the kidney with the invasion of the descending colon mesentery and the abdominal wall. The patient received treatment with a PD-1 antibody (2 weeks/once). However, the patient passed away 18 months after the surgery. With the application of genetic testing technology and advancements in molecular biology, it was expected that specific targeted therapies for this condition would emerge in the future.

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Pulmonary metastasised extraskeletal osteosarcoma

Cited by 4 publications

References 2 publications

Case Report: Primary Extraskeletal Osteosarcoma in the Lung and Pulmonary Artery

Case Report: Primary Extraskeletal Osteosarcoma in the Lung and Pulmonary Artery

Pancreatic Extraskeletal Osteosarcoma Metastasizing to the Scalp

Case report: A case of primary renal osteosarcoma

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