Pulmonary Microbial Composition in Sepsis-Induced Acute Respiratory Distress Syndrome

Zhang, Peng; Zheng, Weihao; Yan-tang, Chen; Wu, Zhentao; Lu, Yuting; Ma, Jie; Liang, Wenjie; Zheng, Mingzhu; Wu, Wanting; Meng, Zijie; Wu, Jang‐Yen; Zheng, Yufeng; Zhang, Xin; Zhang, Shuang; Huang, Yanming

doi:10.3389/fmolb.2022.862570

Cited by 13 publications

(13 citation statements)

References 35 publications

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“…The lung is usually the first target organ attacked by multiple organ dysfunction in sepsis ( 331 , 332 ). The main pathophysiological changes are the destruction of the alveoli-capillary barrier ( 333 ), which leads to increased permeability of pulmonary blood vessels, increased migration of neutrophils to the lungs, and accumulation of protein-rich edema fluid in the alveoli, thus causing tissue and organ damage ( 334 ). Due to the difficulty in balancing the specificity and sensitivity of currently available biomarkers, finding new targeted therapeutic markers is still crucial to prevent ARDS in patients with sepsis.…”

Section: Discussionmentioning

confidence: 99%

The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome

Wang

Zhu²,

Liu³

et al. 2023

Front. Immunol.

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Sepsis is defined as a life-threatening dysfunction due to a dysregulated host response to infection. It is a common and complex syndrome and is the leading cause of death in intensive care units. The lungs are most vulnerable to the challenge of sepsis, and the incidence of respiratory dysfunction has been reported to be up to 70%, in which neutrophils play a major role. Neutrophils are the first line of defense against infection, and they are regarded as the most responsive cells in sepsis. Normally, neutrophils recognize chemokines including the bacterial product N-formyl-methionyl-leucyl-phenylalanine (fMLP), complement 5a (C5a), and lipid molecules Leukotriene B4 (LTB4) and C-X-C motif chemokine ligand 8 (CXCL8), and enter the site of infection through mobilization, rolling, adhesion, migration, and chemotaxis. However, numerous studies have confirmed that despite the high levels of chemokines in septic patients and mice at the site of infection, the neutrophils cannot migrate to the proper target location, but instead they accumulate in the lungs, releasing histones, DNA, and proteases that mediate tissue damage and induce acute respiratory distress syndrome (ARDS). This is closely related to impaired neutrophil migration in sepsis, but the mechanism involved is still unclear. Many studies have shown that chemokine receptor dysregulation is an important cause of impaired neutrophil migration, and the vast majority of these chemokine receptors belong to the G protein-coupled receptors (GPCRs). In this review, we summarize the signaling pathways by which neutrophil GPCR regulates chemotaxis and the mechanisms by which abnormal GPCR function in sepsis leads to impaired neutrophil chemotaxis, which can further cause ARDS. Several potential targets for intervention are proposed to improve neutrophil chemotaxis, and we hope that this review may provide insights for clinical practitioners.

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Section: Discussionmentioning

confidence: 99%

The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome

Wang

Zhu²,

Liu³

et al. 2023

Front. Immunol.

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“…Zhang et al found that different initial sites of infection could influence lung microbiota in patients with septic ARDS. ARDS patients with initial intrapulmonary infection tend to have higher abundance of gut-associated in lung (Zhang et al, 2022). To determine the specific role of gut-lung axis, it is better to make a more nuanced classification in the future.…”

Section: Discussionmentioning

confidence: 99%

“…The composition of gut-associated bacteria, especially Bacteroidetes and Enterobacteriaceae, increased in the lower respiratory tract of ARDS patients (Dickson et al, 2016;Siwicka-Gieroba and Czarko-Wicha, 2020). Further study found that the increase of Escherichia coli in lung was related to higher mortality of ARDS patients (Zhang et al, 2021). Studies have confirmed that the lung microbiota is associated with alveolar inflammation in ARDS (Dickson et al, 2016).…”

Section: Introductionmentioning

confidence: 90%

Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome

Han

Zhou

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundAcute respiratory distress syndrome (ARDS) is the most common cause of organ failure in acute pancreatitis (AP) patients, which associated with high mortality. Specific changes in the gut microbiota have been shown to influence progression of acute pancreatitis. We aimed to determine whether early alterations in the gut microbiota is related to and could predict ARDS occurrence in AP patients.MethodsIn this study, we performed 16S rRNA sequencing analysis in 65 AP patients and 20 healthy volunteers. The AP patients were further divided into two groups: 26 AP-ARDS patients and 39 AP-nonARDS patients based on ARDS occurrence during hospitalization.ResultsOur results showed that the AP-ARDS patients exhibited specific changes in gut microbiota composition and function as compared to subjects of AP-nonARDS group. Higher abundances of Proteobacteria phylum, Enterobacteriaceae family, Escherichia-Shigella genus, and Klebsiella pneumoniae, but lower abundances of Bifidobacterium genus were found in AP-ARDS group compared with AP-nonARDS groups. Random forest modelling analysis revealed that the Escherichia-shigella genus was effective to distinguish AP-ARDS from AP-nonARDS, which could predict ARDS occurrence in AP patients.ConclusionsOur study revealed that alterations of gut microbiota in AP patients on admission were associated with ARDS occurrence after hospitalization, indicating a potential predictive and pathogenic role of gut microbiota in the development of ARDS in AP patients.

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“…An interesting complication of ARDS (referred to as “more of the gut in the lung”) is described for critically ill septic ARDS patients [ 81 , 82 , 83 ]. The microbial population in the lungs of ARDS patients can be enriched in gut-associated microbes (more so, in sepsis caused by extrapulmonary rather than intrapulmonary infections) [ 84 ]. Infection of the lungs by gut-associated microbes is attributed to either oropharyngeal aspiration or translocated from the gut [ 81 ].…”

Section: Microbiota Of the Gut And Lungsmentioning

confidence: 99%

“…Infection of the lungs by gut-associated microbes is attributed to either oropharyngeal aspiration or translocated from the gut [ 81 ]. Due to the inter-individual variability and a low-biomass pool, a specific microbial signature for ARDS is lacking [ 84 ]. Nonetheless, a probiotic approach has been explored in mice, yielding promising results [ 85 ].…”

Section: Microbiota Of the Gut And Lungsmentioning

confidence: 99%

Immunomodulatory Properties of Vitamin D in the Intestinal and Respiratory Systems

et al. 2023

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Vitamin D plays a crucial role in modulating the innate immune response by interacting with its intracellular receptor, VDR. In this review, we address vitamin D/VDR signaling and how it contributes to the regulation of intestinal and respiratory microbiota. We additionally review some components of the innate immune system, such as the barrier function of the pulmonary and intestinal epithelial membranes and secretion of mucus, with their respective modulation by vitamin D. We also explore the mechanisms by which this vitamin D/VDR signaling mounts an antimicrobial response through the transduction of microbial signals and the production of antimicrobial peptides that constitute one of the body’s first lines of defense against pathogens. Additionally, we highlight the role of vitamin D in clinical diseases, namely inflammatory bowel disease and acute respiratory distress syndrome, where excessive inflammatory responses and dysbiosis are hallmarks. Increasing evidence suggests that vitamin D supplementation may have potentially beneficial effects on those diseases.

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Pulmonary Microbial Composition in Sepsis-Induced Acute Respiratory Distress Syndrome

Cited by 13 publications

References 35 publications

The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome

The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome

Altered gut microbiota in the early stage of acute pancreatitis were related to the occurrence of acute respiratory distress syndrome

Immunomodulatory Properties of Vitamin D in the Intestinal and Respiratory Systems

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