Pulmonary mucinous cystadenoma: a rare benign tumor of the lung

Abstract

Pulmonary mucinous cystadenoma (PMCA) is rare, with few reported cases. This tumor is histologically characterized by a benign proliferation of mucin-producing epithelial cells and bulky mucin inside the tumor. We present the case of a 71-year-old woman with increasing mass shadow on chest radiography who underwent tumor resection by video-assisted thoracic surgery. The tumor was diagnosed histologically as PMCA.

Mucinous cystadenocarcinoma arising from mucinous cystadenoma of the lung: case report and review of the literature

“…KRAS point mutations have been suggested to be associated with tumor development in mucinous neoplasms originating from the ovary, appendix or pancreas (4,5). In the literature, there has been only one case of mucinous cystadenoma in the lung that was analyzed for KRAS and EGRF mutations and both were negative.…”

A Rare Case of Mucinous Cystadenoma of the Lung Mimicking Malignancy at 18F-FDG PET/CT

“…Surgical resection with a sufficient margin is required for the treatment. 2 A previous report has described the usefulness of 18 F-FDG PET/CT in a patient with a malignant pulmonary mucinous tumor (mucinous cystadenocarcinoma). 11 In our case, 18 F-FDG PET/CT has been useful in detecting a benign PMCA which mimicked a malignancy by using this functional imaging method.…”

Mucinous Cystadenoma in the Lung of a Captive-born Moustached Tamarin (Saguinus mystax)

“…Mucinous cystic tumours of the lung in man are uncommon and there are fewer than 100 reports in the literature (Davison et al ., 1992; Guimaraes et al ., 2004; Haro-Estarriol et al ., 2004; Gao and Urbanski, 2005; Igai et al ., 2008; Haruki et al ., 2010). Three variants of mucinous cystadenomas are described, including benign mucinous cystadenoma, mucinous cystic tumour with borderline malignancy and mucinous cystadenocarcinoma (Graeme-Cook and Mark, 1991; Davison et al ., 1992; Gao and Urbanski, 2005; Iwasaki et al ., 2007).…”

“…Benign mucinous cystadenomas are well-demarcated, solitary, unilocular or multilocular cystic masses, often but not always surrounded by a fibrous wall. The cystic spaces, which are lined by a well-differentiated cuboidal to columnar mucus-producing epithelium are filled with a few cell remnants and scant to abundant mucin (Roux et al ., 1995; Matsuo et al ., 2005; Igai et al ., 2008; Haruki et al ., 2010), the latter component representing up to 90% of the tumour (Gao and Urbanski, 2005; Haruki et al ., 2010). Mucinous cystic tumours with borderline malignancy have been described as predominantly having a tall mucinous stratified epithelium with cytological atypia, hyperchromatic and pleomorphic nuclei, occasional mitotic figures, foci of cells heaped into tufts or papillae, mucin dissecting the surrounding lung parenchyma, sometimes lymphoplasmacytic infiltrates, and fibrosis (Graeme-Cook and Mark, 1991; Mann et al ., 2001; Haro-Estarriol et al ., 2004), but with no convincing evidence of malignant invasion (Davison et al ., 1992).…”

“…(1992) who speculated that the presence of a fibrous wall was an indicator of longstanding nature. This point is disputed by others (Kragel et al ., 1990; Davison et al ., 1992; Dixon et al ., 1993; Roux et al ., 1995; Guimaraes et al ., 2004; Gao and Urbanski, 2005; Matsuo et al ., 2005; Igai et al ., 2008; Haruki et al ., 2010) who report the presence of a fibrous wall in some benign cystadenomas and absence of a fibrous wall in some malignant forms.…”