Pulmonary mucormycosis in an adolescent female with type 1 diabetes mellitus

Pennell, Erik; Pecson, Iris; Nakamura, Craig; Galvis, Alvaro E.

doi:10.1016/j.idcr.2018.e00474

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…It is a less common opportunistic fungal infection compared to Candida and Aspergillus species [1]. There are six most commonly reported forms which include rhinocerebral, pulmonary, cutaneous, gastrointestinal, disseminated, and uncommon presentations [2,3]. The relative incidence of pulmonary mucormycosis (PM) to other clinical form incidence in literature is about 25% [4].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Mucormycosis: A Case Report of a Rare Infection with Potential Diagnostic Problems

Mekki

Hassan

Falemban

et al. 2020

Case Reports in Pathology

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Pulmonary mucormycosis is a relatively rare pulmonary fungal disease, which is difficult to diagnose early and lacks effective treatment. It is seen in patients with hematological malignancies, diabetes mellitus, and immunocompromised states. The diagnosis depends primarily on the detection of fungi in lung tissue. Here, we present a case of a 52-year-old male who has type 2 diabetes mellitus and a past history of treated pulmonary tuberculosis. Clinical diagnosis is difficult in pulmonary mucormycosis, and early diagnosis is needed for this life-threatening infection. Histopathological examination of a resected cavity confirmed the diagnosis of pulmonary mucormycosis. This report highlights the difficulty of diagnosis and the importance of histological examination in detecting mucormycosis which will help for early management.

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Section: Introductionmentioning

confidence: 99%

Pulmonary Mucormycosis: A Case Report of a Rare Infection with Potential Diagnostic Problems

Mekki

Hassan

Falemban

et al. 2020

Case Reports in Pathology

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“…No underlying immunodeficiency was identified, so the reason for his sensitivity to this opportunistic infection is unclear. Pulmonary mucormycosis has been described in patients in diabetic ketoacidosis [4], and it is speculated that a combination of hyperglycemia and ketoacidosis suppresses innate immune function and promotes fungal spread [4]. However, there is no analogous mechanism in type two diabetes [5,6].…”

Section: Discussionmentioning

confidence: 99%

“…Incidence and management of pulmonary mucormycosis in children is poorly described. One review article described 44 definitive cases identified by registry, of which 63% were associated with malignancy or bone marrow transplant, and 48% of all patients were treated with a combination of antifungal medication and surgery [4]. Combination therapy was associated with lower mortality; however, additional details, such as underlying etiology and surgical intervention, were not reported [4].…”

Section: Introductionmentioning

confidence: 99%

Pediatric pulmonary mucormycosis in a diabetic patient treated with extended pleurectomy and Clagett procedure

Gologorsky

Ely

Rothenberg

et al. 2019

Journal of Pediatric Surgery Case Reports

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Mucor is a ubiquitous fungus that is non-pathogenic in healthy people. In immunocompromised hosts, non-functional or absent neutrophils and macrophages result in fungal invasion and infection [ 1 ]. Invasive mucor (mucormycosis) most commonly involves the sinuses, brain, or lungs. Pulmonary mucormycosis typically presents in patients with a history of organ transplantation or hematologic malignancy [ 2 ], and is rare in patients with diabetes alone. The epidemiology and management of pediatric pulmonary mucormycosis is poorly described. We report an unusual occurrence of this disease, complicated by segmental pulmonary artery thrombus in a 15-year-old with poorly controlled diabetes. His severe, medication-resistant infection was ultimately treated successfully with antifungal medication combined with aggressive surgical debridement. The pulmonary artery segmental thrombus resolved after treatment of the underlying infection without anticoagulation.

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“…It is a less common opportunistic fungal infection compared to Candida and Aspergillus species [1]. There are six most commonly reported forms which include rhinocerebral, pulmonary, gastrointestinal, cutaneous, disseminated, and uncommon presentations [2,3]. The relative incidence of pulmonary mucormycosis (PM) to other clinical form incidence in literature is about 25% [4].…”

Section: Introductionmentioning

confidence: 99%

Invasive Broncho-Pulmonary Mucormycosis (IBPM) Misdiagnosed as Tuberculosis

Patil

2022

ELECTR J MED DENT STUD

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Hemoptysis is nonspecific respiratory symptom with variable etiological factors ranging from infections like tuberculosis, pneumonia, fungal infections to malignant lung process. Although Tuberculosis is leading cause of hemoptysis and reason for empirical treatment and delay in diagnosis, computerized tomography and fiberoptic bronchoscopy has made real change towards approach in management of these cases presented with nonspecific symptoms. In this case report, we have documented 'invasive bronchopulmonary Mucormycosis' as cause of recurrent hemoptysis and persistent pulmonary opacity on chest radiograph irrespective of best possible conventional treatment including higher antibiotics and blanket cover of anti-tuberculosis treatment for 4 months. We have documented 'Reverse halo sign' on chest CT imaging and final diagnosis established with Bronchoscopy guided lung biopsy showing 'presence of fungal infection causing extensive parenchymal necrosis, angioinvasion and cartilage destruction along with bronchiolar invasion.' Caution should be taken during biopsy of these hypervascular lesions as propensity to have post-biopsy 'catastrophic massive hemoptysis.' We have also documented near total complete resolution of airway and lung lesions to medical management including Amphotericin and Posaconazole.

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Pulmonary mucormycosis in an adolescent female with type 1 diabetes mellitus

Cited by 8 publications

References 11 publications

Pulmonary Mucormycosis: A Case Report of a Rare Infection with Potential Diagnostic Problems

Pulmonary Mucormycosis: A Case Report of a Rare Infection with Potential Diagnostic Problems

Pediatric pulmonary mucormycosis in a diabetic patient treated with extended pleurectomy and Clagett procedure

Invasive Broncho-Pulmonary Mucormycosis (IBPM) Misdiagnosed as Tuberculosis

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