Pulmonary Myofibroblastic Tumour Involving the Pericardium and Left Atrium in an 18 Month Infant

Lamas-Pinheiro, Rúben; Rodesch, Gregory; Devalck, Christine; Segers, Valérie; Khelif, Karim; Cappello, Mattéo; Steyaert, Henri

doi:10.5761/atcs.cr.15-00360

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…B-ultrasound, CT, and magnetic resonance imaging are commonly used imaging examinations to diagnose scrotal masses. Although imaging examinations play an important role in diagnosing IMT, postoperative histological examination is the gold standard (23,24). The imaging manifestations of IMT are mass-like lesions with or without patches eroding the surrounding tissue.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Recurrence of Testicular Myofibroblastic Tumor After Surgery

Liu

Bai

et al. 2022

Front. Oncol.

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Inflammatory myofibroblastic tumour (IMT), also known as plasma cell granuloma (PCG) or inflammatory pseudotumour (IPT), is a distinctive, rarely metastasizing neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils. IMT predominantly affects children and young adults, and the age at presentation ranges from 3 to 89 years. We present a very rare case of recurrent testicular IMT without ALK rearrangement. This case highlights the clinical characteristics and diagnostic factors associated with primary and recurrent foci of this rare tumour, along with key therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

Case Report: Recurrence of Testicular Myofibroblastic Tumor After Surgery

Liu

Bai

et al. 2022

Front. Oncol.

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“…Existing case reports of pneumonectomy for IMT also demonstrate favorable results though alternative options such as sleeve lobectomy and pharmacologic therapy to avoid pneumonectomy have also been successful. 8,[18][19][20][21][22] For anaplastic lymphoma kinase (ALK)-positive IMT, pneumonectomy should be reserved for patients with tumors unresectable by more limited procedures including sleeve lobectomy after neoadjuvant crizotinib therapy.…”

Section: Discussionmentioning

confidence: 99%

Pneumonectomy for Pediatric Tumors—a Pediatric Surgical Oncology Research Collaborative Study

et al. 2020

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Objective: To describe utilization and long-term outcomes of pneumonectomy in children and adolescents with cancer. Summary Background Data: Pneumonectomy in adults is associated with significant morbidity and mortality. Little is known about the indications and outcomes of pneumonectomy for pediatric tumors. Methods: The Pediatric Surgical Oncology Research Collaborative (PSORC) identified pediatric patients <21 years of age who underwent pneumonectomy from 1990 to 2017 for primary or metastatic tumors at 12 institutions. Clinical information was collected; outcomes included operative complications, long-term function, recurrence, and survival. Univariate log rank, and multivariable Cox analyses determined factors associated with survival. Results: Thirty-eight patients (mean 12 AE 6 yrs) were identified; median (IQR) follow-up was 19 (5-38) months. Twenty-six patients (68%) underwent pneumonectomy for primary tumors and 12 (32%) for metastases. The most frequent histologies were osteosarcoma (n ¼ 6), inflammatory myofibroblastic tumors (IMT; n ¼ 6), and pleuropulmonary blastoma (n ¼ 5). Median postoperative ventilator days were 0 (0-1), intensive care 2 (1-3), and hospital 8 (5-16). Early postoperative complications occurred in 10 patients including 1 death. Of 25 (66%) patients alive at 1 year, 15 reported return to preoperative pulmonary status. All IMT patients survived while all osteosarcoma patients died during follow-up. On multivariable analysis, metastatic indications were associated with nonsurvival (HR ¼ 3.37, P ¼ 0.045) Conclusion: This is the largest review of children who underwent pneumonectomy for cancer. There is decreased procedure-related morbidity and mortality than reported for adults. Survival is worse with preoperative metastatic disease, especially osteosarcoma.

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“…Although imaging and endoscopic examination play an important role in the diagnosis of IMT, histologic assessment is the gold standard. [26,27] CT scan can confirm the relationship between the lesions and ureter, while ureteroscopy is usually performed when there is a suspect of endoluminal lesions. Ureteroscopy is a useful diagnostic and therapeutic tool because it possesses the functions of removing tumor obstruction and providing biopsy samples.…”

Section: Discussionmentioning

confidence: 99%

Ureteral inflammatory myofibroblastic tumor

Guo²,

Qiu³

et al. 2018

Medicine

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Rationale:Inflammatory myofibroblastic tumor (IMT) is a rare soft-tissue neoplasm which has been described in a variety of locations. In the urogenital system, IMT predominantly occurs in the bladder and the kidney. IMT arising from the ureter is exceedingly rare and has been sporadically reported before.Patient concerns:We reported an extremely exceptional case of IMT arising from the ureteral submucosa in a 54-year-old man. The patient was hospitalized with the main complaint of intermittent and moderate left abdominal pain for 2 months.Diagnoses and Interventions:Computed tomography scan revealed a nearly circular mass in the left upper ureter. Ureteroscopy showed that the ureteral lumen mucosa was smooth. However, the upper ureter was compressed and narrow. Renal dynamic imaging was performed and the measured glomerular filtration rate was 46.98 mL/min (right renal) and 9.77 mL/min (left renal), respectively. A retroperitoneoscopic radical nephroureterectomy was performed. The histopathologic examination revealed that the soft-tissue neoplasm was mainly composed of myofibroblastic spindle cells proliferation with mixed inflammatory infiltrate, containing lymphocytes, neutrophils, and eosinophils. On immunohistochemical staining, the tumor was positive for smooth muscle actin and Ki-67 (<1%+), indicating a confirmed diagnosis of ureteral IMT.Outcomes:The patient recovered well with no occurrence of complications. At 3-year follow-up, there was no radiologic evidence of tumor recurrence or metastasis and the man was well.Lessons:Ureteral IMT is extremely rare and often asymptomatic, resulting in delayed diagnosis. Radiologic evidences may be suggestive of the diagnosis of IMT. However, it is necessary to make an accurate diagnosis in terms of histopathologic assessment. Complete lesion excision is the best therapeutic approach with rare recurrences and excellent survival.

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Pulmonary Myofibroblastic Tumour Involving the Pericardium and Left Atrium in an 18 Month Infant

Cited by 4 publications

References 5 publications

Case Report: Recurrence of Testicular Myofibroblastic Tumor After Surgery

Case Report: Recurrence of Testicular Myofibroblastic Tumor After Surgery

Pneumonectomy for Pediatric Tumors—a Pediatric Surgical Oncology Research Collaborative Study

Ureteral inflammatory myofibroblastic tumor

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