Pulmonary Myxoma in a Sheep

Oryan, Ahmad; Ahmadi, Nasrollah; Ghane, Mohsen; Daneshbod, Yahya

doi:10.1016/j.jcpa.2009.03.006

Cited by 8 publications

(9 citation statements)

References 9 publications

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“…The histological features of MGs are similar to myxomas that have a population of spindle or stellate cells embedded in a matrix rich in acid mucopolysaccharides [47]. Primary pulmonary myxoma not associated to JSRV was also reported in sheep [48,49]. In our study, two cases of pulmonary nodules showed specific gross, histological and histochemical (AB-PAS matrix) features of pulmonary myxoma, and were confirmed through IHC.…”

Section: Discussionsupporting

confidence: 79%

Exogenous Jaagsiekte Sheep Retrovirus type 2 (exJSRV2) related to ovine pulmonary adenocarcinoma (OPA) in Romania: prevalence, anatomical forms, pathological description, immunophenotyping and virus identification

Toma

Balteanu

Tripon

et al. 2020

Preprint

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Background. Ovine pulmonary adenocarcinoma (OPA) is a neoplastic disease caused by exogenous Jaagsiekte Sheep Retrovirus (exJSRV). The prevalence of JSRV-related OPA in Eastern European countries, including Romania is unknown. We aimed to investigate: the prevalence and morphological features of OPA (classical and atypical forms) in Romania, the immunophenotype of the pulmonary tumors and their relationships with exJSRV infection. Methods. Lung tumors from 34 slaughtered adult ewes were grossly evaluated. Cytology, histology, immunocytochemistry, immunohistochemistry, electron microscopy and DNA testing were subsequently performed. Results. Out of 2693 examined sheep, 34 had OPA (1.26% prevalence). The diaphragmatic lobes were the most affected. Grossly, the classical OPA was identified in 88.24% of investigated cases and the atypical OPA in 11.76% that included solitary myxomatous nodules. Histopathology results confirmed the presence of OPA in all suspected cases, which were classified into acinar and papillary types. Myxoid growths (MGs) were diagnosed in 6 classical OPA cases and in 2 cases of atypical form. Lung adenocarcinoma was positive for MCK and TTF-1, and MGs showed immunoreaction for Vimentin, Desmin and SMA; Ki67 expression of classical OPA was higher than atypical OPA and MGs. JSRV-MA was identified by IHC (94.11%) in both epithelial and mesenchymal cells of OPA. ICC and TEM also confirmed the JSRV within the neoplastic cells. ExJSRV was identified by PCR in 97.05% of analyzed samples. Phylogenetic analysis revealed the presence of the exJSRV type 2 in Romanian sheep affected by lung cancer and showed a high similarity with the UK strain (AF105220.1). Conclusions. In this study, we confirmed for the first time in Romania the presence of exJSRV in naturally occurring OPA in sheep. Additionally, we described the first report of atypical OPA in Romania, and to the best of our knowledge, in Eastern Europe. Finally, we showed that MGs have a myofibroblastic origin.

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Section: Discussionsupporting

confidence: 79%

Exogenous Jaagsiekte Sheep Retrovirus type 2 (exJSRV2) related to ovine pulmonary adenocarcinoma (OPA) in Romania: prevalence, anatomical forms, pathological description, immunophenotyping and virus identification

Toma

Balteanu

Tripon

et al. 2020

Preprint

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“…The histopathological findings of the observed myxoma coincide with a pulmonary myxoma reported in a sheep [4] and maxillary sinus in a horse [3]. The outermost part of myxoma was ulcerated and hemorrhagic as a result of continuous trauma.…”

Section: Discussionsupporting

confidence: 64%

“…It is characterized by the presence of myxoid matrix, rich in acid mucopolysaccharides that are produced by a number of spindle-shaped cells [2]. Myxomas were observed in different locations, including the maxillary sinuses in two horses [3], the diaphragmatic lobe of the right lung in a sheep [4], and the interatrial septum of the heart of an older (72-year-old) man [5].…”

Section: Introductionmentioning

confidence: 99%

Gigantic Cutaneous Myxoma at Equine Distal Limb

Zabady

Abdin-Bey

Hassieb

et al. 2012

Journal of Equine Veterinary Science

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confidence: 99%

“…Myxomas have been reported in many species of animals including dogs, cats, horses, cattle and sheep. These tumours have been reported in numerous organs and tissues including skin, heart, lungs, joints and bone (Chandra, Buergelt & Ethell 1999;Campbell & Gelberg 2000;Berrocal, Millán, Ordás & Martín de las Mulas 2001;Yeruham & Perl 2002;Machida, Hoshi, Kobayashi, Katsuda & Yamane 2003;Oryan, Ahmadi, Ghane & Daneshbod 2009 Fish are housed in a 140 m 3 fibreglass pool (9.1 m diameter · 2.4 m deep), in which sea water is re-circulated at a rate of 1135 L min )1 using an airlift-driven bead filter (0.7 m 3 Polygeyser Ò model bead filter). Makeup water drawn from Mission Bay in San Diego, CA is sand-filtered and sterilized with ultraviolet light before being supplied to the pool at a rate of 5-20 L min )1 .…”

mentioning

confidence: 99%