1980
DOI: 10.1203/00006450-198011000-00012
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Pulmonary Nonspecific Defense Mechanisms in Cystic Fibrosis: I. Phagocytic Capacity of Alveolar Macrophages and Neutrophils

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Cited by 11 publications
(3 citation statements)
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“…Patients with CF have an opsonic defect specific for P. aeruginosa that extends to blood-derived polymorphonuclear leukocytes and lung macrophages [24,25]. This deficiency is at least partly responsible for the observation that CF patients experience repeated pulmonary exacerbations even when possessing high levels of anti-P. aeruginosa antibodies.…”
Section: Discussionmentioning
confidence: 99%
“…Patients with CF have an opsonic defect specific for P. aeruginosa that extends to blood-derived polymorphonuclear leukocytes and lung macrophages [24,25]. This deficiency is at least partly responsible for the observation that CF patients experience repeated pulmonary exacerbations even when possessing high levels of anti-P. aeruginosa antibodies.…”
Section: Discussionmentioning
confidence: 99%
“…Studies of BALF neutrophils and macrophages showed similar phagocytic capacity as those of normal children [7], or these functions were decreased in presence of CF serum [8]. Other studies showed decreased phagocytosis of P. aeruginosa [9] or indirect evidence of decreased phagocytosis by accumulation of apoptotic cells in sputa and that this may be related to neutrophil elastase [10].…”
Section: Introductionmentioning
confidence: 94%
“…In the presence of normal serum, pulmonary alveolar macro phages are able to phagocytize P. aeruginosa, Staphylococcus aureus and Candida albicans [90][91][92], CF pulmonary PMN phagocytize C. albicans normally [90] and peripheral PMN can ingest P. aeruginosa with homologous or normal scrum as the opsonic source [93]. C'F macrophages are morphologically normal, but they do not appear to be as actively engaged in phagocytosis as pulmonary PMN [91].…”
Section: Phagocytic Cellsmentioning
confidence: 99%