Pulmonary perspective: immunology in diagnosis and treatment of lung cancer

Weynants, P.; Marchandise, F X; Sibille, Yves

doi:10.1183/09031936.97.10081703

Cited by 18 publications

(18 citation statements)

References 184 publications

(171 reference statements)

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“…One of the major sources are alveolar macrophages (AMs) [23]. Suppression of AMs in the course of lung cancer was observed by others [30]. In our study, negative correlation of TGF-β1 level with the proportion of AMs was found.…”

Section: Discussionsupporting

confidence: 70%

“…In our study, negative correlation of TGF-β1 level with the proportion of AMs was found. TGF-β as a product of tumor cells has a potent immunosuppressive effect on AMs [18,30]. As was shown in a study by Bingisser et al [5], TGF-β may down-regulate apoptosis of alveolar macrophages, and the possible negative feedback may be induced by AMs themselves.…”

Section: Discussionmentioning

confidence: 90%

“…Changes in the cell profile of the bronchoalveolar lavage fluid (BALF) reflect immunologic reactions of the lung in pulmonary malignancies [8,30]. Among the several different cytokines, transforming growth factor (TGF)-β is known to be present in the tumor environment and to have a suppressive effect on host defense [2,10,16,28].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Elevated TGF-β1 concentration in bronchoalveolar lavage fluid from patients with primary lung cancer

Domagała‐Kulawik

Hoser

Safianowska

et al. 2006

Arch. Immunol. Ther. Exp.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 90%

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Elevated TGF-β1 concentration in bronchoalveolar lavage fluid from patients with primary lung cancer

Domagała‐Kulawik

Hoser

Safianowska

et al. 2006

Arch. Immunol. Ther. Exp.

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“…Study of tumor-associated antigens (TAA) detected in cancer patients and their role in the diagnosis and treatment of malignant tumors is an important trend of cancer research [3]. TAA are high-molecular-weight glycoproteins with extremely conservative structure, which may be indicative of their important biological role.…”

Section: Abstract: Natural Autoantibodies; Human Ovarian Cancer; Murmentioning

confidence: 99%

Interactions between natural autoantibodies to tumor-associated human ovarian cancer antigen and murine ovarian cancer cells CaO-1

et al. 1999

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The interactions between tumor cells and autoantibodies to tumor-associated human ovarian cancer antigen isolated from the plasma of a non-cancer patient are demonstrated using an original model of pseudomucinous murine ovarian carcinoma CaO-1. The use of natural autoantibodies for active immunotherapy of tumors may be more effective and safe than murine monoclonal antibodies to CA 125, because there will be no reaction to a toreign protein. Key Words: natural autoantibodies; human ovarian cancer; murine ovarian cancerStudy of tumor-associated antigens (TAA) detected in cancer patients and their role in the diagnosis and treatment of malignant tumors is an important trend of cancer research [3]. TAA are high-molecular-weight glycoproteins with extremely conservative structure, which may be indicative of their important biological role. For example, the peptide sequences of human and chimpanzee MUC 1 antigen differ by only 1% [2].There are no published data on the homology of glycoproteins expressed in human and murine ovarian cancer. In the present study we attempted to detect common antigenic determinants for glycoproteins expressed in human ovarian cancer and experimental mouse tumors of the same origin. This study was prompted by the detection of high titers of autoantibodies (autoAB) to human ovarian cancer TAA in the plasma of a non-cancer patient. Natural autoAB purified by affinity chromatography were used for examining the TAA of homologous murine tumors. The data can be used for studying natural autoAB and TAA to glycoprotein CA 125 expressed in patients with ovarian cancer and for detecting TAA homology in humans and mice with histologically similar tumors. MATERIALS AND METHODSThe study was carried out on an original model of murine mixed pseudomucinous ovarian carcinoma CaO-1 obtained and maintained in CBA mice. Similar tumors often occur in humans. This cell strain (frozen at the second generation) is highly sensitive to cytostatics routinely used in human ovarian cancer. We assume that the antigenic characteristics of this tumor remained unchanged. Relatively rapid growth of the tumor also is an important factor.Female CBA mice aged 2-3 months were used. CaO-1 ovarian cancer cells were transplanted subcutaneously in a dose of 10 6 cells in 0.3 ml medium 199. The cells were isolated from the tumor node on day 21 after tumor transplantation.

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“…mutated or overexpressed oncogene products or differentiation anticens (Boon. 1997: Wevnants. 1997 Miller (1979) Oral 308 No benefit McKneally (1981) Intrapleural 169 Improved survival (stage 1) Mountain (1981) Table 2. EL-2 used alone or in combination xxith other cvtokines or ly mphokine-actixated killer (LAK) cells in phase II trials in NSCLC has induced some responses (Table 3).…”

Section: Tumour Immunologymentioning

confidence: 99%

Immunotherapy in lung cancer

Al-Moundhri¹,

O'Brien²,

Souberbielle³

1998

Br J Cancer

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Summary More research and new treatment options are needed in all stages of lung cancer. To this end immunotherapy needs a revival in view of recent improved technologies and greater understanding of the underlying biology.In this review we discuss mechanisms of tumour immunotherapy, non-specific, specific and adoptive, with particular reference to a direct therapeutic action on all subtypes of lung cancer.

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Pulmonary perspective: immunology in diagnosis and treatment of lung cancer

Abstract: Finally, the discovery of several tumour rejection antigens has revived the dream of designing tumour vaccines and active specific immunotherapy.

Cited by 18 publications

References 184 publications

Elevated TGF-β1 concentration in bronchoalveolar lavage fluid from patients with primary lung cancer

Elevated TGF-β1 concentration in bronchoalveolar lavage fluid from patients with primary lung cancer

Interactions between natural autoantibodies to tumor-associated human ovarian cancer antigen and murine ovarian cancer cells CaO-1

Immunotherapy in lung cancer

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