Pulmonary pseudallescheriasis in a patient with healed tuberculosis

Bashir, Gulnaz; Shakeel, Saman; Wani, Tehmeena; Kakru, Dalip K

doi:10.1007/s11046-004-2224-7

Cited by 13 publications

(7 citation statements)

References 9 publications

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“…[14] For the domain of causality, 14 reports did not describe the conduction of follow-up, 11 reported a follow-up period shorter than 12 months and 1 reported a loss to follow-up. [7] For the domain of reporting, 7 reports failed to show sufficient details about antifungal treatment duration. [7,15–20]…”

Section: Resultsmentioning

confidence: 99%

“…[7] For the domain of reporting, 7 reports failed to show sufficient details about antifungal treatment duration. [7,15–20]…”

Section: Resultsmentioning

confidence: 99%

“…[5,6] Among them, pulmonary infection ranked 2nd. Although usually attack patients with underlying pulmonary disorders, [7] Scedosporium spp also affect otherwise healthy patients. [8]…”

Section: Introductionmentioning

confidence: 99%

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Scedosporium spp lung infection in immunocompetent patients

2019

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Section: Resultsmentioning

confidence: 99%

“…[7] For the domain of reporting, 7 reports failed to show sufficient details about antifungal treatment duration. [7,15–20]…”

Section: Resultsmentioning

confidence: 99%

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Scedosporium spp lung infection in immunocompetent patients

2019

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“…), colonization of the airways may be permanent and the saprobic state of scedosporium may ensue. The most common predisposition factors for both colonization and fungus ball formation are tuberculosis, sarcoidosis, and previous bacterial infections that result in cysts and cavities (27). Fungus balls in preexisting cavities can be seen in otherwise normal hosts, but invasive disease is usually limited to immunosuppressed patients (8,68,277,376,448,482,485).…”

Section: Saprobic Involvement/colonization Of Airwaysmentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

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SUMMARY Scedosporium spp. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. Scedosporium spp. also cause a wide spectrum of conditions, including mycetoma, saprobic involvement and colonization of the airways, sinopulmonary infections, extrapulmonary localized infections, and disseminated infections. Invasive scedosporium infections are also associated with central nervous infection following near-drowning accidents. The most common sites of infection are the lungs, sinuses, bones, joints, eyes, and brain. Scedosporium apiospermum and Scedosporium prolificans are the two principal medically important species of this genus. Pseudallescheria boydii, the teleomorph of S. apiospermum, is recognized by the presence of cleistothecia. Recent advances in molecular taxonomy have advanced the understanding of the genus Scedosporium and have demonstrated a wider range of species than heretofore recognized. Studies of the pathogenesis of and immune response to Scedosporium spp. underscore the importance of innate host defenses in protection against these organisms. Microbiological diagnosis of Scedosporium spp. currently depends upon culture and morphological characterization. Molecular tools for clinical microbiological detection of Scedosporium spp. are currently investigational. Infections caused by S. apiospermum and P. boydii in patients and animals may respond to antifungal triazoles. By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans.

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“…Similar to Aspergillus spp., P. boydii is predominantly a pulmonary pathogen that may be associated with pulmonary tuberculosis. 16 In our case, the source was a wound infection. A mold wound infection must be taken seriously in transplant recipients, and the early administration of an antifungal agent may have prevented fatal spreading.…”

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confidence: 62%