Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area

Sager, Tina M.; Kommineni, Choudari; Castranova, Vincent

doi:10.1186/1743-8977-5-17

Cited by 219 publications

(183 citation statements)

References 24 publications

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“…This is due to the relatively low lung burdens employed in the present study. For example, Sager et al (2008) reported the dose and time dependence of pulmonary inflammation and lung damage after intratracheal instillation of nano or fine TiO 2 . The rat strain and assay methods used by Sager et al (2008) were identical to those used in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…For example, Sager et al (2008) reported the dose and time dependence of pulmonary inflammation and lung damage after intratracheal instillation of nano or fine TiO 2 . The rat strain and assay methods used by Sager et al (2008) were identical to those used in the present study. The lowest lung burden employed in the Sager et al (2008) study of 260 μg/rat resulted in an 11-fold increase in PMNs harvested by BAL 1 day postexposure.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles

McKinney

Jackson

Sager

et al. 2012

Inhalation Toxicology

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Our laboratory has previously demonstrated that application of an antimicrobial spray product containing titanium dioxide (TiO 2 ) generates an aerosol of titanium dioxide in the breathing zone of the applicator. The present report describes the design of an automated spray system and the characterization of the aerosol delivered to a whole body inhalation chamber. This system produced stable airborne levels of TiO 2 particles with a median count size diameter of 110 nm. Rats were exposed to 314 mg/m 3 min (low dose), 826 mg/m 3 min (medium dose), and 3638 mg/m 3 min (high dose) of TiO 2 under the following conditions: 2.62 mg/m 3 for 2 h, 1.72 mg/m 3 4 h/day for 2 days, and 3.79 mg/m 3 4 h/day for 4 days, respectively. Pulmonary (breathing rate, specific airway resistance, inflammation, and lung damage) and cardiovascular (the responsiveness of the tail artery to constrictor or dilatory agents) endpoints were monitored 24 h post-exposure. No significant pulmonary or cardiovascular changes were noted at low and middle dose levels. However, the high dose caused significant increases in breathing rate, pulmonary inflammation, and lung cell injury. Results suggest that occasional consumer use of this antimicrobial spray product should not be a hazard. However, extended exposure of workers routinely applying this product to surfaces should be avoided. During application, care should be taken to minimize exposure by working under well ventilated conditions and by employing respiratory protection as needed. It would be prudent to avoid exposure to children or those with pre-existing respiratory disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles

McKinney

Jackson

Sager

et al. 2012

Inhalation Toxicology

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“…One of the possible reasons for disagreement is that many studies have been performed using particles with different particle size, surface properties, impurities and crystal structures, involving complex interactions among many factors, and it has been difficult to separate the sole effects of particle size and surface area among many factors. For example, in the research of Bermudez et al 31,32) and Sager et al 35) the TiO 2 nano-and micro-particles used came from different sources and had different crystal structures. Both used the 80% anatase -20% rutile form of TiO 2 particles, generally known by the product name P25, made by Evonik as TiO 2 nanoparticles.…”

Section: Tio 2 Nanoparticlesmentioning

confidence: 99%

“…Both used the 80% anatase -20% rutile form of TiO 2 particles, generally known by the product name P25, made by Evonik as TiO 2 nanoparticles. On the other side, rutile TiO 2 particles produced by DuPont 32) or Sigma Aldrich 35) were used as TiO 2 microparticles. Also, in some studies, measurements of the particles used in the studies were insufficient, making it all the more difficult to validate the nanoparticle paradigm.…”

Section: Tio 2 Nanoparticlesmentioning

confidence: 99%

Hazard Assessments of Manufactured Nanomaterials

Morimoto

Kobayashi

Shinohara

et al. 2010

Journal of Occupational Health

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Hazard Assessments of Manufactured Nanomaterials: Yasuo MORIMOTO, et al. Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, JapanBackground: It has been difficult to make reliable hazard assessments of manufactured nanomaterials, because the nanomaterials form large agglomerations in both in vitro and in vivo studies. Objective: In the New Energy and Industrial Technology Development Organization (NEDO) Project of Japan, the physicochemical properties of many manufactured nanomaterials are being measured, and in vitro and in vivo studies are being performed to determine which endpoints are correspond to the hazards and risks of nanomaterials. Focusing on titanium dioxide, fullerenes and carbon nanotubes, we introduce findings made in inhalation and intratracheal installation studies overseas, and together with the findings made in the NEDO project, and also assess the hazards presented by manufactured nanomaterials. Results and Conclusion : A project by NEDO has succeeded in ensuring the stability of dispersion (nanoscale <100 nm) of manufactured nanomaterials, and is developing hazard assessments of manufactured nanomaterials. In these interim reports, the acceptable exposure concentration of titanium dioxide and fullerene was proposed to be 1.2 mg/m 3 and 0.8 mg/m 3 respirable dust in working environment, respectively. (J Occup Health 2010; 52: 325-334)

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“…It was thought that TiO 2 -NPs were non-toxic mineral (Sager et al 2008). However, many studies suggested that titanium dioxide nanoparticles could be more toxic than their original materials (Long et al 2007;Zhao Jet al 2009;Zhao Jet al 2011;Magaye and Zhao 2012;Liu K et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Role of Carnosine and Melatonin in Ameliorating Cardiotoxicity of Titanium Dioxide Nanoparticles in the Rats

Al-Rasheed¹,

Faddah²,

Ibrahim

et al. 2015

Braz. arch. biol. technol.

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The aim of this work was to study the possible cardiotoxicity of two different doses of 50 nm nano titanium dioxide (n-TiO 2 ) and the possible modulating effects of the use of two natural antioxidants carnosine and melatonin. The results showed that TiO 2-NPs produced deleterious effects on rat cardiac tissue as confirmed by the increased levels of serum myoglobin, troponin-T and CK-MB. Increased levels of serum Inflammatory markers represented by the tumor necrosis factor alpha (TNF-α) and

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Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area

Cited by 219 publications

References 24 publications

Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles

Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles

Hazard Assessments of Manufactured Nanomaterials

Role of Carnosine and Melatonin in Ameliorating Cardiotoxicity of Titanium Dioxide Nanoparticles in the Rats

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