Pulmonary Toxicity During Granulocyte Colony Stimulating Factor Administration and Neutrophils

Katoh, Masako; Takada, Masafumi; Nakayama, M; Umeda, Masanori

doi:10.1378/chest.110.2.576-a

Cited by 11 publications

(5 citation statements)

References 4 publications

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“…G-CSF may exaggerate cytokine dysregulation, which frequently occurs in the rapid recovery phase of haematopoiesis after PBSC transplantation and is clinically recognised as engraftment syndrome. In the literature, G-CSF has been shown to activate pre-existing inflammatory eye disease or even induce the disease,33 34 to cause transient hypoxemia,35 36 hypercoagulable state,37 lower threshold of seizure in patients with central nervous system (CNS) lupus,38 and induce flares of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis 39. For these reasons, patients with autoimmune diseases undergoing non-myeloablative autologous HSCT at our centre are mobilised with Cy and G-CSF and are administered G-CSF for faster WBC engraftment starting day +5 of HSCT.…”

Section: Discussionmentioning

confidence: 99%

Autologous non-myeloablative haematopoietic stem cell transplantation for refractory systemic vasculitis

Statkute

Oyama

Barr

et al. 2007

Annals of the Rheumatic Diseases

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Section: Discussionmentioning

confidence: 99%

Autologous non-myeloablative haematopoietic stem cell transplantation for refractory systemic vasculitis

Statkute

Oyama

Barr

et al. 2007

Annals of the Rheumatic Diseases

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Section: Toxicity During Cytokine Therapymentioning

confidence: 99%

“…Other side effects due to G-CSF are headache, splenomegaly, anemia, thrombocytopenia, hypersensitivity and urticarial at injection site [52,54]. G-CSF-also induced lung toxicity post cancer chemotherapy [55][56][57].GM-CSF treatment has greater frequency of side effects -most common being fever accompanied with influenza-like syndrome and myalgias [58]. Flushing, hypotension, tachycardia, dyspnea and musculoskeletal pain are the first dose reaction due to the GM-CSF administration.…”

mentioning

confidence: 99%

Cytokines and their Role in Health and Disease: A Brief Overview

Gulati¹,

Guhathakurta²,

Joshi³

et al. 2016

MOJI

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Cytokines are small, non-structural proteins with low molecular weights which have a complex regulatory influence on inflammation and immunity. It has long been considered that development of immune and inflammatory response involves hematopoietic cells, lymphoid cell, and various pro-inflammatory and anti-inflammatory cells, and cytokines mediate the complex interactions of these cells. Cytokines are the intercellular messengers in the immune system where they integrate function of several cell types in various body compartments into a coherent immune response. They have evolved over the years and now include the interferons, the interleukins, the chemokine family, mesenchymal growth factors, the tumor necrosis factor family and adipokines. Earlier known as `soluble factors`, cytokines are produced by and elicit a response from every cell, with the lone exception of the red blood cell. In response to various stimulus cytokines are secreted from various cells including white blood cells. Pleiotropism is the hallmark of a cytokine and there are failures and successes of cytokines and related agents as therapeutic agents. In the membrane of target cells they have specific receptors for their signal transduction and regulatory functions. Beyond the innate and adaptive immunity, cytokines has a major role in many diverse functions including immune cell differentiation, inflammation, angiogenesis, tumorigenesis, neurobiology, viral pathogenesis etc. In addition to inflammation, immunity and infections, cytokines have now expanded their domain to atherosclerosis and cancer. Thus, cytokines may be useful biomarkers for health and disease and act as diagnostic, prognostic and therapeutic agents. This review will highlight the impact of cytokines in various physiological actions, pathophysiological states, therapeutics and the complex interactions between brain and immune cells. knowledge has highlighted the complexity and biphasic nature of cytokines -and the same molecule may have beneficial as well as detrimental effects. For example, interferon-γ (IFNγ), which is essential for defense against several intracellular microorganism such as Mycobacterium tuberculosis, is also a major cytokine in the pathogenesis of several autoimmune diseases. IL-2 is needed for the generation of cytotoxic T-cells (CTL) and forms the basis for several vaccines but the same cytokine drives graft versus host disease and limits the success of bone marrow transplantation [5]. Keywords: Cytokine ReceptorsThe cytokines exert various biological effects through receptors present on the membranes of responsive target cells. These receptors have an extracellular domain, a cytoplasmic domain and a single membrane spanning domain. There is the presence of conserved amino acid sequence motifs on the extracellular domain and these motifs include four conserved cysteine residues. There is also the presence of two polypeptide chains. One is the cytokine specific α subunit and other is a signal transducing β subunit.The nature of the target cell ...

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“…Interstitial pneumonitis has developed during G-CSF administration in 2 patients whose malignant lymphomas were treated with chemotherapy (22). Five patients have been reported with rapidly increasing dyspnea and fever and bilateral diffuse interstitial infiltrates following chemotherapy for aggressive non-Hodgkin lymphoma, despite a normal white blood cell count.…”

Section: Growth Factor Toxicity In Patients With Malignancy Treated Wmentioning

confidence: 99%

Fatal Pulmonary Toxicity Related to the Administration of Granulocyte Colony-Stimulating Factor in Amyloidosis: A Report and Review of Growth Factor-Induced Pulmonary Toxicity

Gertz

Lacy

Björnsson

et al. 2000

Journal of Hematotherapy & Stem Cell Research

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We report on a 59-year-old man with renal amyloidosis who died after three doses of granulocyte colony-stimulating factor were administered. Noncardiac pulmonary edema was precipitated by the growth factor. Autopsy revealed amyloid in the lung not visible by plain chest radiograph. Patients with amyloidosis who are candidates for stem cell transplantation and are mobilized with growth factors must be monitored for unexpected pulmonary toxicity. We review the in vitro experimental evidence as well as the clinical data on the pulmonary toxicity of growth factors.

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Pulmonary Toxicity During Granulocyte Colony Stimulating Factor Administration and Neutrophils

Cited by 11 publications

References 4 publications

Autologous non-myeloablative haematopoietic stem cell transplantation for refractory systemic vasculitis

Autologous non-myeloablative haematopoietic stem cell transplantation for refractory systemic vasculitis

Cytokines and their Role in Health and Disease: A Brief Overview

Fatal Pulmonary Toxicity Related to the Administration of Granulocyte Colony-Stimulating Factor in Amyloidosis: A Report and Review of Growth Factor-Induced Pulmonary Toxicity

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