Autologous non-myeloablative haematopoietic stem cell transplantation for refractory systemic vasculitis

Abstract

We suggest non-myeloablative autologous HSCT is an alternative therapy for select patients with SV refractory to conventional immunosuppressive therapies.

Long-term remission in pediatric Wegener granulomatosis following allo-SCT after reduced-intensity conditioning

“…4 Auto-SCT for WG has been associated with persistence of ANCAs and new autoimmune phenomena. 8 In the presented patient, transfusion-and G-CSF-resistant pancytopenia was a limiting factor for auto-SCT. Other immunomodulatory approaches such as anti-CD20 moAb have been successfully used, but may be restricted to nongranulomatous lesions and responses may be temporary.…”

On reversing the persistence of memory: Hematopoietic stem cell transplant for autoimmune disease in the first ten years

“…The Chicago group reported four patients treated with auto-HSCT for treatment refractory systemic vasculidities in abstract form in 2006 [77]. Of these, two patients had Behcet vasculitis, while one each suffered from Wegener's granulomatosis and Sjogren's syndrome with vascular involvement.…”

Stem Cell Therapy in Autoimmune Rheumatic Diseases: a Comprehensive Review

“…Three SS patients with refractory systemic vasculitis or lymphoma receiving auto-HSCT developed amelioration of the vasculitis and lymphoma but not the SS [101]. Another two patients with severe and refractory SS were able to tolerate high-dose immunosuppressive drugs and auto-HSCT and had temporarily alleviation of disease [102].…”