Pulmonary tuberculosis due to bacille Calmette-Gu�rin

Kirsten, D; Rieger, Ulrich M.; Schröder, K H; Böhle, Andreas; Magnussen, H

doi:10.1007/bf00190319

Cited by 7 publications

(3 citation statements)

References 24 publications

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“…Only mild systemic symptoms, such as fever, malaise, and chills, as well as local symptoms of lower urinary tract are generally reported that usually resolve within a few hours or days. From scientific literature, we have noticed at least 37 cases of miliary pulmonary tubercolosis related to BCG instillation (4, 11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-29-30-31-32-33-34-35-36-37-38-39-40-41-42-43-44-45-46). We know that pulmonary complications could be of two kinds: hypersensitivity and mycobacterial pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Intravesical BCG Therapy as Cause of Miliary Pulmonary Tuberculosis

et al. 2015

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Immunotherapy with intravesical bacillus Calmette-Guérin (BCG) is considered the most effective adjuvant to endoscopic resection of bladder urothelial carcinoma in the therapeutic management of non-muscle invasive (NMIBC) at intermediate and high risk of recurrence and progression (pTa - pT1 and high-grade carcinoma in situ, CIS). Despite its proven efficacy, this type of treatment can determine local and systemic side effects of moderate or severe gravity, with the histological diagnosis of epithelioid granulomas in different organs, even in the absence of microbiological positivity of BCG. The immunotherapy with BCG is usually well tolerated and the virulence of the attenuated BCG is very low in immuno-competent patients, although only 16% of patients are able to receive all the instillations of the maintenance period (3 years) of treatment provided by the protocols, precisely because of side effects. Minor side effects usually resolve within a few hours or days. They develop in 3-5% of patients and usually consist of local infectious complications. Manifestations of BCG dissemination, such as vascular and ocular complications, are much less common, while BCG-disseminated infections, with granulomatous pneumonia or hepatitis present, are quite rare, representing 0.5-2% of the complications recorded. We present the clinical case of granulomatous lung and possibly liver infection caused by BCG in a patient aged 56 years being treated for several weeks with intravesical BCG for NIMBC pT1 high grade associated with CIS.

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Section: Discussionmentioning

confidence: 99%

Intravesical BCG Therapy as Cause of Miliary Pulmonary Tuberculosis

et al. 2015

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“…In a series of 2,602 patients, local complications of BCG immunotherapy occurred in about 3% of patients [2]. General side effects like fever, renal abscess, sepsis and BCG-induced pulmonary [3, 4, 5]and miliary tuberculosis [6, 7]are rare and mainly reported in the form of case reports. Therefore the true incidence of systemic side effects remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Nearly Fatal Complications of Cervical Lymphadenitis following BCG Immunotherapy for Superficial Bladder Cancer

Geldmacher

Taube²,

Markert³

et al. 2001

Respiration

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This report describes the case of a 68-year-old man with bilateral cervical lymphadenitis and chorioretinitis due to bacille Calmette-Guérin (BCG), originating from BCG immunotherapy for treatment of superficial bladder cancer 2 years ago. During antimycobacterial therapy a fistula between the right-sided lymph node and an aneurysm of the carotid artery developed. This led to life-threatening spontaneous bleeding which required vascular graft surgery. Like other known systemic side effects, cervical lymphadenitis may also occur following intravesical BCG immunotherapy, and life-threatening complications cannot be excluded despite adequate medical treatment.

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“…Eine Literatursuche bei ¹Pubmedª ergab 12 Artikel über pulmonale Komplikationen, z. B. über Fälle mit granulomatöser Pneumonie [16] sowie Lungen-und Miliartuberkulose [9,14,18,20], die direkt durch BCG verursacht wurden oder mit hypersensiblen Reaktionen und Lungenkrankheiten assoziiert waren [1,13,15].…”

Section: Therapieunclassified

Durch Bacillus Calmette-Guerin induzierte Tuberkulose

Frickmann¹,

Jungblut²,

Hanke³

et al. 2004

Pneumologie

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We describe a case of miliary tuberculosis induced by Bacillus Calmette-Guerin (BCG) as a complication of an infection after BCG-instillation therapy into the bladder because of bladder carcinoma. Bacilli surely entered blood circulation via an urethral lesion because of a difficult catheterisation. The 60 year old patient was administered to the hospital with septic temperature 4 four days after BCG instillation. CT showed a miliary patten and the diagnosis was confirmed by bronchoscopy: transbronchial biopsy showed granulomatous infiltration and an acid-fast rod-bacterium was detected in bronchial slime. Symptoms vanished after a consequent antituberculous triple therapy regime and the patient left hospital in a good general state of health.

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Pulmonary tuberculosis due to bacille Calmette-Gu�rin

Cited by 7 publications

References 24 publications

Intravesical BCG Therapy as Cause of Miliary Pulmonary Tuberculosis

Intravesical BCG Therapy as Cause of Miliary Pulmonary Tuberculosis

Nearly Fatal Complications of Cervical Lymphadenitis following BCG Immunotherapy for Superficial Bladder Cancer

Durch Bacillus Calmette-Guerin induzierte Tuberkulose

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