Pulmonary Tuberculosis in Lung and Heart–Lung Transplantation: Fifteen Years of Experience in a Single Center in Spain

Morales, P.; Briones, Ana M.; Torres, Juan J.; Solé, Amparó; Pérez, Daniel; Pastor, A.

doi:10.1016/j.transproceed.2005.09.144

Cited by 49 publications

(31 citation statements)

References 18 publications

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“…The risk of disseminated infection and death due to tuberculosis (TB) is higher in transplant recipients (3). Posttransplant TB is more common in lung recipients (2.6% in Spain) than in liver transplant patients (1.6% in Brazil), although the variation may depend on the local incidence of infection rather than the organ transplanted (4,5). Transplant candidates should be screened for latent tuberculosis infection (LTBI), i.e.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and Management of Tuberculosis in Transplant Donors: A Donor-Derived Infections Consensus Conference Report

Morris

Daly

Blumberg

et al. 2012

American Journal of Transplantation

127

147

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Mycobacterium tuberculosis is a ubiquitous organism that infects one-third of the world's population. In previous decades, access to organ transplantation was restricted to academic medical centers in more developed, low tuberculosis (TB) incidence countries. Globalization, changing immigration patterns, and the expansion of sophisticated medical procedures to medium and high TB incidence countries have made tuberculosis an increasingly important posttransplant infectious disease. Tuberculosis is now one of the most common bacterial causes of solid-organ transplant donor-derived infection reported in transplant recipients in the United States. Recognition of latent or undiagnosed active TB in the potential organ donor is critical to prevent emergence of disease in the recipient posttransplant. Donor-derived tuberculosis after transplantation is associated with significant morbidity and mortality, which can best be prevented through careful screening and targeted treatment. To address this growing challenge and provide recommendations, an expert international working group was assembled including specialists in transplant infectious diseases, transplant surgery, organ procurement and TB epidemiology, diagnostics and management. This working group reviewed the currently available data to formulate consensus recommendations for screening and management of TB in organ donors.

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Section: Introductionmentioning

confidence: 99%

Diagnosis and Management of Tuberculosis in Transplant Donors: A Donor-Derived Infections Consensus Conference Report

Morris

Daly

Blumberg

et al. 2012

American Journal of Transplantation

127

147

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show abstract

“…The source of TB infection could be difficult to identify. It may be caused by direct exposure to the bacillus after transplantation causing new primary infection, reactivation of a lesion from the donor lung, or reactivation of a non-pulmonary primary infection in the recipient (2,3). Furthermore, the required immunosuppression therapy in transplantation may promote the occurrence of infection (4,6).…”

Section: Commentmentioning

confidence: 99%

“…These challenges include atypical clinical presentations, increased likelihood of negative tuberculin skin tests and/ or interferon-gamma release assays, and negative sputum smear results despite active disease (4,7). The treatment of TB in transplant recipients also has its own challenges, which include pharmacokinetic interactions between immunosuppressive and antituberculous medications, allograft-related drug toxicities, and inadequate immune responses to mycobacterium TB due to exogenous immunosuppression (2,4).…”

Section: Commentmentioning

confidence: 99%

“…Tuberculosis (TB) is a serious opportunistic infection reported in lung transplant recipients. It's incidence ranges between 6.5% and 10% (2). The incidence of TB among transplanted recipients in North America is 36 to 74-fold higher than in the general population (3).…”

Section: Introductionmentioning

confidence: 99%

“…The TB could present as pulmonary tuberculosis (2)(3)(4)(5), an isolated pleural infection with TB (1,5), this presentation with tuberculous pericardial tamponade after lung transplant is unique.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pulmonary tuberculous and tuberculous pericardial tamponade post lung transplant

2017

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Pulmonary tuberculosis (TB) associated with tuberculous pericarditis after lung transplantation is a very rare entity. Here we report a unique case of cardiac tamponade due to tuberculous pericarditis, in a patient 4 months after single right lung transplantation, the patient underwent a subxyphoid pericardial window. The pericardial effusion analysis showed exudate effusion with high level of lymphocyte concentration. Both patient and donor didn't have history of TB or TB Exposure.

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Antimycobacterial Consideration in Transplantation Including Drug Non-susceptibility and Resistance: Tuberculosis and Nontuberculous Mycobacterial Disease

Philley

Griffith²

2019

Principles and Practice of Transplant Infectious Diseases

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Pulmonary Tuberculosis in Lung and Heart–Lung Transplantation: Fifteen Years of Experience in a Single Center in Spain

Cited by 49 publications

References 18 publications

Diagnosis and Management of Tuberculosis in Transplant Donors: A Donor-Derived Infections Consensus Conference Report

Diagnosis and Management of Tuberculosis in Transplant Donors: A Donor-Derived Infections Consensus Conference Report

Pulmonary tuberculous and tuberculous pericardial tamponade post lung transplant

Antimycobacterial Consideration in Transplantation Including Drug Non-susceptibility and Resistance: Tuberculosis and Nontuberculous Mycobacterial Disease

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