PulmonaryAspergillus-associated calcium oxalate crystals

Modem, Rukmini; Florence, Roxanne; Goulart, Robert A.; Pantanowitz, Liron

doi:10.1002/dc.20517

Cited by 10 publications

(11 citation statements)

References 3 publications

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“…The possibility that CA, at least in some cases, are formed by mycoses is supported by several lines of evidence. First, CA contain several salts, including calcium phosphate and calcium oxalate, and these salts have also been detected as deposits in fungal infections (Tanaka et al, 1993 ; Nakagawa et al, 1999 ; Modem et al, 2006 ; Rassaei et al, 2009 ). Second, proteins from neutrophil granules appear in CA and it is well established that fungal infections elicit a neutrophil response (Murthy et al, 1993 ; Metzler et al, 2011 ; Cunha et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Corpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with Specific Antifungal Antibodies

et al. 2016

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The origin and potential function of corpora amylacea (CA) remains largely unknown. Low numbers of CA are detected in the aging brain of normal individuals but they are abundant in the central nervous system of patients with neurodegenerative diseases. In the present study, we show that CA from patients diagnosed with Alzheimer's disease (AD) contain fungal proteins as detected by immunohistochemistry analyses. Accordingly, CA were labeled with different anti-fungal antibodies at the external surface, whereas the central portion composed of calcium salts contain less proteins. Detection of fungal proteins was achieved using a number of antibodies raised against different fungal species, which indicated cross-reactivity between the fungal proteins present in CA and the antibodies employed. Importantly, these antibodies do not immunoreact with cellular proteins. Additionally, CNS samples from patients diagnosed with amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) also contained CA that were immunoreactive with a range of antifungal antibodies. However, CA were less abundant in ALS or PD patients as compared to CNS samples from AD. By contrast, CA from brain tissue of control subjects were almost devoid of fungal immunoreactivity. These observations are consistent with the concept that CA associate with fungal infections and may contribute to the elucidation of the origin of CA.

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Section: Discussionmentioning

confidence: 99%

Corpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with Specific Antifungal Antibodies

et al. 2016

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“…Oxalate crystals in aspergillosis may be seen in a variety of anatomical sites such as lung, pleura, sinonasal tract, and ear [9]. The crystals can be identified in tissue as well as cytologic specimens before the culture becomes positive [1,8]. In tissue, crystal deposition is typically seen in the vicinity of the infection and in the cavity wall, where oxalic acid can cause parenchymal and vascular damage not infrequently resulting in hemorrhage [10].…”

Section: Discussionmentioning

confidence: 99%

“…Deposition of calcium oxalate crystals in fungal infections, especially with Aspergillus spp in the lung, is well known and is considered to be an important diagnostic feature [2,3,8]. The crystals are most often associated with Aspergillus niger infection followed by A flavus and A fumigatus [1,3].…”

Section: Discussionmentioning

confidence: 99%

Deposition of calcium salts in a case of pulmonary zygomycosis: histopathologic and chemical findings

et al. 2009

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“…Aspergillus fumigatus and related species have a worldwide distribution and are commonly found in the upper respiratory tract, paranasal sinuses, lungs and mediastinal lymph nodes and disseminate in immunocompromised patients to skin and central nervous system and other sites. 24 Candida spp. [1][2][3] The hyphae stain variably and weakly in Pap and Giemsa stains or as negative images in a background of necrosis or suppuration, and are well seen in the GMS.…”

Section: Granulomatous Patternmentioning

confidence: 99%

“…In the lung aspergillosis can cause cavitating lesions which can be associated with squamous metaplasia showing atypia raising the DD of squamous cell carcinoma, and calcium oxalate crystals. 24 Candida spp. Candida is a commensal and causes localized infections commonly in the skin, oropharynx, esophagus, and vagina and disseminates widely in immunocompromised patients particularly HIV positive patients where it is an AIDS defining infection.…”

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confidence: 99%

Role of fine needle aspiration biopsy cytology in the diagnosis of infections

Field

Geddie

2016

Diagnostic Cytopathology

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The role of fine needle aspiration biopsy (FNAB) cytology in diagnosing infections has expanded due to the increase in the number of immune compromised patients and the increasing role of FNAB in the developing world where infection is a major cause of illness. FNAB has become the first procedural test in cases where the clinical and imaging findings suggest an infectious lesion or where there is a differential diagnosis of infection or metastatic or primary tumor. This applies to FNAB of palpable or image directed or deep seated lesions accessed by EUS and EBUS. This article details a recommended approach and technique for FNAB of infectious lesions, and discusses the role of rapid on site evaluation and the application of ancillary testing including the rapidly expanding array of molecular tests based on FNAB material. The utility of recognizing suppurative and granulomatous infectious patterns in FNAB direct smears, and the specific cytomorphological features on routine Papanicolaou and Giemsa stains and on special stains of FNAB smears is described for a large number of bacterial, fungal, viral, parasitic, and protozoan infections. The role of cytopathologists is to now train cytopathologists in sufficient numbers to provide FNAB services, teach trainee cytopathologists and cytotechnologists, and to encourage our clinical colleagues to use FNAB in the diagnosis of infections and other lesions to the benefit of patients and the medical system. Diagn. Cytopathol. 2016;44:1024-1038. © 2016 Wiley Periodicals, Inc.

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PulmonaryAspergillus-associated calcium oxalate crystals

Cited by 10 publications

References 3 publications

Corpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with Specific Antifungal Antibodies

Corpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with Specific Antifungal Antibodies

Deposition of calcium salts in a case of pulmonary zygomycosis: histopathologic and chemical findings

Role of fine needle aspiration biopsy cytology in the diagnosis of infections

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