Deposition of calcium salts in a case of pulmonary zygomycosis: histopathologic and chemical findings

Cutaneous and mucosal mucormycosis mimicking pancreatic panniculitis and gouty panniculitis

“…Several types of crystals, mostly calcium salt crystals including calcium oxalate and calcium carbonate, have been described in the cytopathologic and histopathologic samples obtained from pulmonary aspergillosis 20-22 as well as pulmonary and subcutaneous mucormycosis. 23,24 These fungi are thought to produce oxalic acid as a product of the tricarboxylic acid cycle by hydrolysis of oxaloacetate by oxaloacetate acetylhydrolase. Oxalate reacts with the calcium present in the serum or tissue and forms calcium oxalate that is deposited primarily as monohydrate crystals.…”

Oxalose Bronchique Isolée, Signe Inaugural d'une Aspergillose Pulmonaire Nécrosante Chronique

“…Dans certains cas, des agents infectieux peuvent être incriminés [1]. La détection de ces cristaux dans un contexte clinique infectieux est fortement suggestive d'une infection aspergillaire [2,3]. Elle doit faire rechercher cette étiologie même en l'absence de filaments mycéliens identifiés sur les prélèvements en provenance des voies respiratoires ou des cavités naso-sinusiennes [3][4][5].…”

“…En 1996, Dutton et al ont identifié 27 espèces de champignons produisant l'acide oxalique in vitro [7]. Parmi ces champignons, la famille aspergillus semble être le principal agent pathogène entraînant des dépôts d'oxalate in vivo chez l'homme [2,7] ; les infections aux zygomycètes (mucorales) sont exceptionnellement liées à la production d'acide oxalique in vivo [2,9].…”

Tracheal oxalosis associated withAspergillus nigertracheobronchitis

“…We only have found two cases of tracheobronchial oxalosis in the literature; a tracheal involvement in a patient who probably aspirated a piece of rhubarb [10], and bronchial oxalosis in a patient with pulmonary mucormycosis [8].…”

“…Oxalosis is a condition in which calcium oxalate crystals accumulate in different organs. Oxalosis has been documented in patients with pulmonary aspergillosis [7] or mucormycosis [8] infections. However, there is no previous report in the medical literature of tracheal oxalosis associated with Aspergillus infection.…”