Tracheal oxalosis associated with<i>Aspergillus niger</i>tracheobronchitis

Gómez, Fernando; Tarín, Virginia; Cuadrado, Marta; Vecilla, Francisco; Blanquer, David; Costa-Bauzà, Antònia; Gráses, F.; Bachiller, Daniel

doi:10.1183/09031936.00185312

Cited by 7 publications

(12 citation statements)

References 11 publications

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“…Regions of normal tissue in affected organs did not contain oxalate crystals. In 9 of 14 cases with crystals, fungal infection was noted in multiple respiratory tissues (cases 2, 3, 5, 6,9,10,13,15,16). All cases with crystals in multiple respiratory tissues were birds (9 of 11 avian cases with crystals).…”

Section: Resultsmentioning

confidence: 99%

“…This may occur because fungi that synthesize oxalic acid do so as a product of the tricarboxylic acid cycle, 34 which requires oxygen. Human cases also predominantly involve the lung, with occasional cases involving the nasal cavity, 27 sinuses, 27 trachea, 15 and nasopharynx. 10 Individual human cases of A. niger infections with oxalate crystals have been reported outside of the respiratory tract, including otomycosis with crystals in the tympanic membrane, 21 and 2 cases of infection in a gangrenous foot.…”

Section: Discussionmentioning

confidence: 99%

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A retrospective study of the prevalence of calcium oxalate crystals in veterinary Aspergillus cases

et al. 2016

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Fungi in the genus Aspergillus are some of the most common fungal pathogens in veterinary species, primarily affecting the respiratory tract. In both human and veterinary cases, calcium oxalate crystals have been documented in sites of Aspergillus infection. Cases in multiple species (16 birds, 15 horses, 5 dogs, 1 ox, and 1 dolphin) were identified that had either positive cultures for Aspergillus sp., or had conidiophores present that could be identified as belonging to the genus Aspergillus. Histologic slides were examined to confirm the presence of oxalate crystals and how often they were identified on the original report. Calcium oxalate deposition was detected in 14 of 38 cases examined, including A. fumigatus, A. versicolor, A. niger, and unspecified Aspergillus sp. infections. Calcium oxalate crystals were identified in 11 of 16 avian cases, as well as in 1 of 1 bovine, 1 of 15 equine, and 1 of 5 canine cases. Crystals were described in only 3 of the 14 original pathology reports of these cases, indicating that identification and reporting of crystals in histologic specimens could be improved. All the tissues with crystals were respiratory tissues with air interfaces, including nasal sinus, trachea, syrinx, lung, and air sac. In cases with crystals identified on H&E-stained sections, crystals were frequently not present or were fewer in number in tissue sections stained with Gomori methenamine silver and periodic acid-Schiff. Routine polarization of slides of fungal infections, especially in the respiratory tract, should be considered to check for calcium oxalate crystals.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A retrospective study of the prevalence of calcium oxalate crystals in veterinary Aspergillus cases

et al. 2016

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“…Revising the literature, ulcerative disruption of respiratory tract, descending from invasive Aspergillus laryngotracheal infection, are reported in adults [e.g., (9,10,14,20,25,(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)] and in adolescents (15 and 17 years old) (47,48) but not in pediatric patients. According to our knowledge, only Barnes et al (49) and Athanassiadou et al (50) described Aspergillus laryngotracheobronchitis in children (6 and 2 years old) affected by acute lymphocytic leukemia; however, in these cases, the characterizing elements included plaques and necrotic cells, whereas ulcerative lesions were not reported.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Sudden Fatal Hemorrhage in Ulcerative Fungal Laryngotracheitis—A Pediatric Case Report

et al. 2022

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In this report, we describe an autopsy case of a child affected by acute lymphoblastic leukemia and opportunistic pulmonary aspergillosis. The patient died because of a full-thickness tracheal wall ulceration with right inferior thyroid artery lesion and sudden hemorrhage, likely ascribable to undiagnosed invasive Aspergillus laryngotracheitis. Aspergillus infection, particularly in immunocompromised patients, should be considered an urgent risk factor to manage as it may lead to sudden fatal events in absence of evident critical symptoms.

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“…Enfin, deux cas d'oxalose bronchique associés à une infection mycosique ont été décrits dans la littérature. Il est donc intéressant de rechercher des cristaux d'oxalate, en lumière polarisée, sur les prélèvements en provenance des voies respiratoires même hautes (trachéo-bronchiques), notamment dans un contexte infectieux [15]. CONCLUSION L'identification de cristaux d'oxalate sur des prélèvements broncho-pulmonaires cytologiques ou histologiques, dans un contexte d'infection, doit soulever le diagnostic d'une étiologie mycosique le plus souvent de type aspergillaire ; ceci permettrait d'initier une prise en charge précoce et de limiter l'évolution de la maladie.…”

Section: Introductionunclassified

Oxalose Bronchique Isolée, Signe Inaugural d'une Aspergillose Pulmonaire Nécrosante Chronique

Nassereddine¹,

Naderi²,

Rassy³

2017

LMJ

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Tracheal oxalosis associated withAspergillus nigertracheobronchitis

Cited by 7 publications

References 11 publications

A retrospective study of the prevalence of calcium oxalate crystals in veterinary Aspergillus cases

A retrospective study of the prevalence of calcium oxalate crystals in veterinary Aspergillus cases

Case Report: Sudden Fatal Hemorrhage in Ulcerative Fungal Laryngotracheitis—A Pediatric Case Report

Oxalose Bronchique Isolée, Signe Inaugural d'une Aspergillose Pulmonaire Nécrosante Chronique

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