Pulp response after calcitonin treatment of direct exposures in the dog

Cullum, Daniel R.; Kline, Loren

doi:10.1016/0030-4220(85)90297-x

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…After all of the fluid was absorbed, it was ready for use. This method is similar to that described previously (6). It provided a means of applying a standard amount of each agent applied to the pulp.…”

Section: Methodsmentioning

confidence: 98%

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Effects of Calcitonin, Calcitonin Gene-Related Peptide, Human Recombinant Bone Morphogenetic Protein-2, and Parathyroid Hormone–Related Protein on Endodontically Treated Ferret Canines

Kline¹,

Yu²

2009

Journal of Endodontics

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Section: Methodsmentioning

confidence: 98%

“…When CT was applied directly on pulpotomized dog teeth, there was no significant increase in the amount of tertiary dentin formed when compared with dog teeth treated with Ca(OH) 2 . The CT-treated teeth had a reduced degree of inflammation when compared with the control teeth (6).…”

mentioning

confidence: 97%

Effects of Calcitonin, Calcitonin Gene-Related Peptide, Human Recombinant Bone Morphogenetic Protein-2, and Parathyroid Hormone–Related Protein on Endodontically Treated Ferret Canines

Kline¹,

Yu²

2009

Journal of Endodontics

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“…It was first explored as a pulp-capping agent in 1982 when Smith and Soni (1982) used a rat model for comparing pulp capping using Ca(OH) 2 and calcitonin and discovered that calcitonin produced a similar response in terms of dentine deposition to Ca(OH) 2 . Similarly, in a dog model, Cullum and Kline (1985) found that although calcitonin was able to induce pulp-capping dentineogenesis, it did not outperform Ca(OH) 2 ; although, less inflammation was identified in the calcitonin group. More recently, calcitonin has also been shown to stimulate osteodentine deposition in ferrets (Kline and Yu, 2009), adding to the growing literature supporting this bioactive molecule as a potential candidate for inclusion in a biomimetic PCA.…”

Section: Calcitoninmentioning

confidence: 92%

Bioactive molecules for regenerative pulp capping

Whitehouse¹,

Thomson²,

et al. 2021

eCM

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Since the discovery of bioactive molecules sequestered in dentine, researchers have been exploring ways to harness their activities for dental regeneration. One specific area, discussed in this review, is that of dental-pulp capping. Dental-pulp caps are placed when the dental pulp is exposed due to decay or trauma in an attempt to enhance tertiary dentine deposition. Several materials are used for dental-pulp capping; however, natural biomimetic scaffolds may offer advantages over manufactured materials such as improved aesthetic, biocompatibility and success rate. The present review discusses and appraises the current evidence surrounding biomimetic dental-pulp capping, with a focus on bioactive molecules sequestered in dentine. Molecules covered most extensively in the literature include transforming growth factors (TGF-βs, specifically TGF-β1) and bone morphogenetic proteins (BMPs, specifically BMP-2 and BMP-7). Further studies would need to explore the synergistic use of multiple peptides together with the development of a tailored scaffold carrier. The roles of some of the molecules identified in dentine need to be explored before they can be considered as potential bioactive molecules in a biomimetic scaffold for dental-pulp capping. Future in vivo work needs to consider the inflammatory environment of the dental pulp in pulpal exposures and compare pulp-capping materials.

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The Effect of Calcitonin on Osseous Healing in Guinea Pig Mandible

Doğan

Özçelik²,

Gedikoğlu³

et al. 2001

Journal of Endodontics

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Calcitonin (CT) is reported to be an effective medication for the treatment of inflammatory root resorption and to be capable of stimulating osteoblast proliferation in cell culture studies. In this study the effect of CT on the healing of osseous defects was evaluated in the mandibles of guinea pigs. After raising tissue flaps two experimental cavities were created on both sides of the corpus mandible of 33 guinea pigs. CT was applied into cavities either in hydroxypropyl methycellulose (HPMC) gel or gelatin as carrier. HPMC and gelatin alone and an empty cavity were also examined as control groups. Histopathological examinations under light microscopy were performed on weeks 1, 3, and 6. At week 1 in CT+gelatin and CT+HPMC groups, prominent osteoblastic activity was observed when compared with control groups. At week 3 the presence of woven bone in the experimental cavity areas reflected the increased osteoblastic activity in all groups. At the end of week 6 woven bone was gradually replaced by osteogenic tissue undergoing remodelization with Haversian systems in all groups. It is suggested that the osseous healing of the experimental cavity was enhanced by CT application in early stages (i.e. at week 1). However there was no significant difference of osteogenic activity between the control and CT-treated groups at the end of weeks 3 and 6.

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Pulp response after calcitonin treatment of direct exposures in the dog

Cited by 7 publications

References 13 publications

Effects of Calcitonin, Calcitonin Gene-Related Peptide, Human Recombinant Bone Morphogenetic Protein-2, and Parathyroid Hormone–Related Protein on Endodontically Treated Ferret Canines

Effects of Calcitonin, Calcitonin Gene-Related Peptide, Human Recombinant Bone Morphogenetic Protein-2, and Parathyroid Hormone–Related Protein on Endodontically Treated Ferret Canines

Bioactive molecules for regenerative pulp capping

The Effect of Calcitonin on Osseous Healing in Guinea Pig Mandible

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