Pulpal responses following direct pulp capping of healthy dog teeth with dentine adhesive systems

Koliniotou-Koumpia, Eugenia; Tziafas, Dimitrios

doi:10.1016/j.jdent.2004.12.007

Cited by 69 publications

(72 citation statements)

References 39 publications

(42 reference statements)

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“…This is an important finding, since it is known that all materials can induce different levels of acute inflammation in the pulp. 3,4 Moreover, Single Bond was able to induce a significantly higher secretion of IL-8 than MTA. Since IL-8 is a potent neutrophil chemotactic protein, secretion of this cytokine by migrating neutrophils was expected.…”

Section: Discussionmentioning

confidence: 96%

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Pulp capping materials exert an effect on the secretion of IL-1β and IL-8 by migrating human neutrophils

et al. 2011

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Pulp repair is a complex process whose mechanisms are not yet fully understood. The first immune cells to reach the damaged pulp are neutrophils that play an important role in releasing cytokines and in phagocytosis. The objective of this study was to analyze the effect of different pulp-capping materials on the secretion of interleukin-1 beta (IL-1β) and interleukin-8 (IL-8) by migrating human neutrophils. Neutrophils were obtained from the blood of three healthy donors. The experimental groups were calcium hydroxide [Ca(OH) 2 ], an adhesive system (Single Bond), and mineral trioxide aggregate (MTA). Untreated cells were used as control. Transwell chambers were used in performing the assays to mimic an in vivo situation of neutrophil chemotaxis. The pulpcapping materials were placed in the lower chamber and the human neutrophils, in the upper chamber. The cells were counted and the culture medium was assayed using ELISA kits for detecting and quantifying IL-1β and IL8. The data were compared by ANOVA followed by Tukey's test (p < 0.05). The secretion of IL-8 was significantly higher in all groups in comparison to the control group (p < 0.05). The adhesive system group showed higher IL-8 than the MTA group (p < 0.05). The secretion of IL-1β was significantly greater only in the MTA group (p < 0.001). It was concluded that only MTA is able to improve the secretion of IL-1β, and all materials tested increased IL-8 secretion. These results combined with all the other biological advantages of MTA indicate that it could be considered the material of choice for dental pulp capping.

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Section: Discussionmentioning

confidence: 96%

“…However, the physical limitations of these materials have led researchers and clinicians to seek new materials. 4 Adhesive systems have expanded the range of possibilities of tooth restoration. However, when in contact with the dental pulp, they may trigger an inflammatory process of varying intensities.…”

Section: Introductionmentioning

confidence: 99%

Pulp capping materials exert an effect on the secretion of IL-1β and IL-8 by migrating human neutrophils

et al. 2011

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“…Materials able to stimulate pulp tissue repair and tertiary dentin formation have been investigated extensively in pulp-capping situations (Koliniotou-Koumpia & Tziafas, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effect ofAloe vera. on Rat Pulp Tissue

Gala-García

Teixeira

Mendes

et al. 2008

Pharmaceutical Biology

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“…[1] Since Hermanm first successfully used calcium hydroxide (CH) for repairing dentin in 1930, biomaterials able to stimulate pulp tissue repair and tertiary dentine formation have been attracted much attention in pulp capping situations. [2,3] Because of the low-grade irritation of the traumatized pulp tissue, CH-based materials have been the material of choice for pulp capping traditionally. [4] However, known disadvantages of the CH-containing materials, such as nonadherence to dentine, dissolution in tissue fluids, tunnel defects in dentinal bridge, and poor sealing properties, have led scientists to seek new agents.…”

Section: Introductionmentioning

confidence: 99%

A novel silicate‐doped calcium‐based composite dental pulp capping agent

Chen

Mao

Liu

et al. 2009

Asia-Pacific J Chem Eng

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The development of a dental pulp capping agent (DPCA) requires suitable setting time, acceptable compressive strength, favorable bioactivity, and to facilitate cementum tissue regeneration. Calcium phosphate cement (CPC) is widely used for its self-setting, biodegradability, biocompatibility, and formability. However, a relative low strength and lack of bioactivity have limited its application. Herein, dicalcium silicate (Ca 2 SiO 4 , C 2 S) was introduced into CPC to prepare a novel silicate-doped CPC/C 2 S composite DPCA by self-setting in situ and its setting time, compressive strength, bioactivity, and biomineralization behaviors were investigated. The results indicated that the mechanical strength and setting time of DPCA were higher than those of pure CPC. C 2 S transformed into a C-S-H gel without disturbing the hydration of DPCA after soaking in SBF for 5 days. Moreover, much more bone-like hydroxyapatite layers were formed, and DPCA exhibited higher bioactivity mainly in virtue of the rapid formation of C-S-H. DPCA with 15 wt% C 2 S, suggested to be the optimized composite, exhibited significantly improved bioactivity and high compressive strength, indicating that DPCA with 15 wt % C 2 S might have a significant pulp capping therapy advantage over the pure CPC. 

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Pulpal responses following direct pulp capping of healthy dog teeth with dentine adhesive systems

Cited by 69 publications

References 39 publications

Pulp capping materials exert an effect on the secretion of IL-1β and IL-8 by migrating human neutrophils

Pulp capping materials exert an effect on the secretion of IL-1β and IL-8 by migrating human neutrophils

Effect ofAloe vera. on Rat Pulp Tissue

A novel silicate‐doped calcium‐based composite dental pulp capping agent

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